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“Basal-Like” Triple Negative

Expression  of  P 16 ink4a in basal like triple negative breast carcinoma in Sudanese women

Expression of P 16 ink4a in basal like triple negative breast carcinoma in Sudanese women

... with triple negative breast carcinoma ...truly basal- like cancer and raise the possibility that triplenegative breast cancer with cytokertin, and p16 co-expression may ...

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Cytotoxicity Study of Gold Nanoparticles on the Basal Like Triple Negative HCC 1937 Breast Cancer Cell Line

Cytotoxicity Study of Gold Nanoparticles on the Basal Like Triple Negative HCC 1937 Breast Cancer Cell Line

... The Triple NegativeBasal-like” breast cancer (TNBL) tumours have a high proliferative capacity and develop a resistance phenotype associated with me- ...

13

A clinically relevant gene signature in triple negative and basal like breast cancer

A clinically relevant gene signature in triple negative and basal like breast cancer

... drugs like anti-CTLA-4 antibodies that have shown pro- mise in melanoma ...ple negative paradox with high relapse rates despite a good initial response to ...

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Podocalyxin enhances breast tumor growth and metastasis and is a target for monoclonal antibody therapy

Podocalyxin enhances breast tumor growth and metastasis and is a target for monoclonal antibody therapy

... aggressive triple-negative, basal-like breast cancer cell line, se- verely impaired primary tumor growth and metastasis to the lung, liver and bone marrow in a xenograft ...

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AlyssaHo_BSPH_Thesis_2020.pdf

AlyssaHo_BSPH_Thesis_2020.pdf

... Background: Among US women, basal-like and triple-negative breast cancer subtypes confer worse patient survival due to a lack of targetable receptors. Furthermore, obesity is a major public ...

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Clinicopathologic features of triple negative breast cancers: an experience from Pakistan

Clinicopathologic features of triple negative breast cancers: an experience from Pakistan

... receptor negative breast cancers were associated with black race and young age at first ...for triple negative breast cancer, although they didn’t find a significant association with breast feeding ...

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Targeting PIK3CG in Combination with Paclitaxel as a Potential Therapeutic Regimen in Claudin-Low Breast Cancer

<p>Targeting PIK3CG in Combination with Paclitaxel as a Potential Therapeutic Regimen in Claudin-Low Breast Cancer</p>

... Abbreviations: CLBC, Claudin-low breast cancer; PIK3CG, PI3K catalytic subunit gamma; PTX, paclitaxel; TNBC, Triple negative breast cancer; BLBC, basal-like breast cancer; PR, progestero[r] ...

11

SHP2 acts both upstream and downstream of multiple receptor tyrosine kinases to promote basal like and triple negative breast cancer

SHP2 acts both upstream and downstream of multiple receptor tyrosine kinases to promote basal like and triple negative breast cancer

... Because ligand-induced receptor processing impacts sig- naling output, we analyzed the same total cell lysates for EGFR to see if loss of SHP2 affects this process. Surpris- ingly, we found that the level of EGFR in the ...

14

PubMedCentral-PMC5140046.pdf

PubMedCentral-PMC5140046.pdf

... and basal-like and claudin-low tumors to the brain, lung, and liver ...with triple-negative breast cancer (TNBC), with both cases also of the basal-like breast cancer intrinsic ...

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Basal-like breast cancer defined by five biomarkers has superior prognostic value than triple-negative phenotype.pdf

Basal-like breast cancer defined by five biomarkers has superior prognostic value than triple-negative phenotype.pdf

... (47 basal cytokeratin-expressing breast cancers and 49 stage-matched but mainly ER+ controls; ...the basal-like subtype is a potential candidate to respond well to ...study, basal-like ...

9

Immunohistochemical Profile and Morphology in Triple – Negative Breast Cancers

Click here to download PDF version of the article !

... the triple- negative phenotype has been considered as sufficient to identify the ‘basal-like’ tumours, increasing evidence has shown that the terms ‘basal-like’ and ...

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LncRNAs as new biomarkers to differentiate triple negative breast cancer from non-triple negative breast cancer

LncRNAs as new biomarkers to differentiate triple negative breast cancer from non-triple negative breast cancer

... B, basal-like, and Her-2 +) in 2005 [6]; 2) In 2009, TNBC was identified as resulting from chromosomal abnormalities, such as chromosomal band deletion of PTEN/RASA1 and EGFR/VEGFA/FAS overexpression [7, ...

13

Comprehensive transcriptome analysis identifies novel molecular subtypes and subtype specific RNAs of triple negative breast cancer

Comprehensive transcriptome analysis identifies novel molecular subtypes and subtype specific RNAs of triple negative breast cancer

... BL1: basal-like-1; BL2: basal-like-2; BLIS: basal-like and immune-suppressed; CDF: empirical cumulative distribution function; ECM: extracellular matrix; ER: estrogen receptor; ...

10

ANTINEOPLASTIC AND PROTEOMIC SIGNATURE OF SIMVASTATIN TREATED CD44+/ CD24- TRIPLE NEGATIVE BREAST CANCER STEM -LIKE CELLS

ANTINEOPLASTIC AND PROTEOMIC SIGNATURE OF SIMVASTATIN TREATED CD44+/ CD24- TRIPLE NEGATIVE BREAST CANCER STEM -LIKE CELLS

... Based on the functional role of DEPs in relation to TNBCSCs , western blotting analysis was performed on some selected proteins (such as “HSPB1, Vinculin” which were significantly downregulated upon Simvastatin ...

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Mouse mammary stem cells express prognostic markers for triple negative breast cancer

Mouse mammary stem cells express prognostic markers for triple negative breast cancer

... (MES), basal-like im- mune-suppressed (BLIS), and basal-like immune-activated (BLIA); and the six TNBC subtypes identified by Lehmann and colleagues [33], namely two basal-like ...

23

Triple negative breast cancer: shedding light onto the role of pi3k/akt/mtor pathway

Triple negative breast cancer: shedding light onto the role of pi3k/akt/mtor pathway

... Basal-like 1 (BL1) and Basal-like 2 (BL2) subtypes: both are characterized by up-regulation of gene and cellular markers mainly implicated in cell growth. In fact, Ki-67 expression and nuclear ...

11

Ataxin-3 like (ATXN3L), a member of the Josephin family of deubiquitinating enzymes, promotes breast cancer proliferation by deubiquitinating Krüppel-like factor 5 (KLF5)

Ataxin-3 like (ATXN3L), a member of the Josephin family of deubiquitinating enzymes, promotes breast cancer proliferation by deubiquitinating Krüppel-like factor 5 (KLF5)

... To further confirm whether ATXN3L knockdown decreases KLF5 protein stability in human breast cancer cells, we knocked down ATXN3L in HCC1806 and SUM1315 (two basal type triple negative breast cancer ...

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Triple negative breast cancer

Triple negative breast cancer

... Th e introduction of HRs in clinical routine use not only showed the usefulness of endocrine therapy in HR- positive cases (60 to 80%) but also the special aggressive- ness of HR-negative cases. Even today, ...

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p53 Expression in Triple Negative Breast Carcinomas: Evidence of Age Related and Racial Differences

p53 Expression in Triple Negative Breast Carcinomas: Evidence of Age Related and Racial Differences

... of basal-like TNBC has been entertained and thus accurate subclassification of TNBC into basal-like and other subtypes is becoming more clinically relevant ...

6

Does vimentin help to delineate the so-called 'basal type breast cancer'?

Does vimentin help to delineate the so-called 'basal type breast cancer'?

... between triple negative and non-triple negative breast cancer is reduced with longer follow-up period ...When basal phenotype markers like CK 5/6 and HER1 (EGFR) were analyzed ...

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