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Basic Helix Loop Helix (bHLH) DNA-binding domain

Multiple Basic Helix-Loop-Helix Proteins Regulate Expression of the ENO1 Gene of Saccharomyces cerevisiae

Multiple Basic Helix-Loop-Helix Proteins Regulate Expression of the ENO1 Gene of Saccharomyces cerevisiae

... Pho4p binding but not Cbf1p binding ...the basic charged DNA- binding domain (HLH) and therefore can dimerize with other bHLH proteins but prevent their binding to ...from ...

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Phylogenetic analysis of the human basic helix loop helix proteins

Phylogenetic analysis of the human basic helix loop helix proteins

... Orange domain, which is characteristic of most HER proteins and provides them with functional specificity ...the basic domain that confers DNA- binding specificity on the HER proteins ...

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Dominant Alleles of the Basic Helix-Loop-Helix Transcription Factor ATR2 Activate Stress-Responsive Genes in Arabidopsis

Dominant Alleles of the Basic Helix-Loop-Helix Transcription Factor ATR2 Activate Stress-Responsive Genes in Arabidopsis

... R/B-related basic helix-loop-helix et ...acidic domain plus a bHLH DNA binding/ activators for a number of plant biosynthetic and devel- dimerization domain near ...

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Overexpression of hypoxia-inducible factor and metabolic pathways: possible targets of cancer

Overexpression of hypoxia-inducible factor and metabolic pathways: possible targets of cancer

... bHLH: basic helix loop helix; PAS: Per ARNT Sim; ODD: oxygen-dependent domain; N-TAD: N-terminal transactivational domain; C-TAD: C-terminal trans- activational domain; ...

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Human induced pluripotent stem cell differentiation and direct transdifferentiation into corneal epithelial-like cells

Human induced pluripotent stem cell differentiation and direct transdifferentiation into corneal epithelial-like cells

... The pioneering work by Yamanaka and colleagues to induce pluripotent cells from somatic cells by retroviral infection of defined transcription factors in 2006 [8], paved the way for others to improve the protocols, using ...

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Proceedings of the fourth international conference on central hypoventilation

Proceedings of the fourth international conference on central hypoventilation

... A pacemaker implantation should be performed in chil- dren with congenital atrioventricular block and with one of the risk conditions: a wide QRS escape rhythm, or com- plex ventricular ectopy, or prolonged QTc interval, ...

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Molecular Consequences of Ds Insertion Into and Excision From the Helix-Loop-Helix Domain of the Maize R Gene

Molecular Consequences of Ds Insertion Into and Excision From the Helix-Loop-Helix Domain of the Maize R Gene

... activities. Relative luciferase levels were calculated by dividing r-m1 differed by the insertion of 404 bp into helix 2 of the average luciferase/CAT ratio for each construct by that the bHLH motif (Figure 2, B ...

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Oligomerization Mediated by a Helix-Loop-Helix-Like Domain of Baculovirus IE1 Is Required for Early Promoter Transactivation

Oligomerization Mediated by a Helix-Loop-Helix-Like Domain of Baculovirus IE1 Is Required for Early Promoter Transactivation

... the binding of IE1 as a dimer to the 28-bp palindromic repeats comprising the hr ...enhancer binding, as demonstrated by in vitro pull-down assays using fusions of IE1 (582 residues) to the C terminus of ...

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Molecular mediators of hepatic steatosis and liver injury

Molecular mediators of hepatic steatosis and liver injury

... Carbohydrate (glucose)-mediated stimulation of lipogenesis is transcrip- tionally mediated by a second bHLH- Zip transcription factor, designated carbohydrate response element bind- ing protein (ChREBP) (36). Glucose ...

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Autoimmunogenicity of the helix-loop-helix DNA-binding domain

Autoimmunogenicity of the helix-loop-helix DNA-binding domain

... Indirect ELISAs were performed on the MaxiSorb 96-well plates (Nunc, Denmark). Coating with peptide RT-P was performed with 100 g/ml solution in 0.05 M carbonate buffer, pH9.3, for 20 h at 20C, followed by 3 days at ...

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BHLHE40 confers a pro survival and pro metastatic phenotype to breast cancer cells by modulating HBEGF secretion

BHLHE40 confers a pro survival and pro metastatic phenotype to breast cancer cells by modulating HBEGF secretion

... Protein-DNA crosslink, nuclear fraction extraction, and chromatin fragmentation were performed as described pre- viously [26]. The soluble fraction of sheared chromatin (200–500 bp in length) was pre-cleaned with ...

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Derepression of INO1 Transcription Requires Cooperation between the Ino2p-Ino4p Heterodimer and Cbf1p and Recruitment of the ISW2 Chromatin-Remodeling Complex

Derepression of INO1 Transcription Requires Cooperation between the Ino2p-Ino4p Heterodimer and Cbf1p and Recruitment of the ISW2 Chromatin-Remodeling Complex

... Our results showed that Cbf1p was required for the full derepression of INO1 transcription under derepressing (I ⫺ C ⫺ ) conditions (Fig. 2 and 3). We also found that the Cbf1p- mediated regulation of INO1 required one ...

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Transcriptional induction of slit diaphragm genes by Lmx1b is required in podocyte differentiation

Transcriptional induction of slit diaphragm genes by Lmx1b is required in podocyte differentiation

... LMX1B binding sites in putative regulatory regions of the CD2AP and NPHS2 genes (Fig- ure 5) and the ability of LMX1B to transactivate the NPHS2 –825 site (Figure 6) strengthen our conclusion that Lmx1b positively ...

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MyoD and the regulation of myogenesis by helix loop helix proteins

MyoD and the regulation of myogenesis by helix loop helix proteins

... Many members of the HLH protein family, including the MyoD family of myogenic regulatory genes, have a region rich in basic amino acids that is immediately amino-terminal to the HLH doma[r] ...

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Cell Cycle Exit: Growth Arrest, Apoptosis, and Tumor Suppression Revisited

Cell Cycle Exit: Growth Arrest, Apoptosis, and Tumor Suppression Revisited

... group of basic helix-loop-helix (HLH) factors, which induce muscle differentiation and cause growth arrest long before induction of muscle proteins.. Careful analysis of the region invol[r] ...

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From biological clock to biological rhythms

From biological clock to biological rhythms

... a basic-helix-loop-helix-PAS (bHLH-PAS) protein (Clock) which is required for activating the transcription of other clock genes (mPer1-3, and the genes for mouse cryp- tochromes 1 and 2) and ...

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Investigating interactions between methylenomycin furan microbial hormones and transcriptional repressors in Streptomyces coelicolor

Investigating interactions between methylenomycin furan microbial hormones and transcriptional repressors in Streptomyces coelicolor

... potentially binding to the MARE operator and repressing ...homologous helix-turn-helix DNA binding region which sometimes may share enough sequence identity to bind to one another’s ...

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DNA binding and unwinding by Hel308 helicase requires dual functions of a winged helix domain

DNA binding and unwinding by Hel308 helicase requires dual functions of a winged helix domain

... RecA-like domain separates DNA strands during Hel308 helicase activity and Hel308 is also effective at removing other DNA bound proteins (5,15,16,22), contributing to recovery of compromised ...

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DNA binding and unwinding by Hel308 helicase requires dual functions of a winged helix domain

DNA binding and unwinding by Hel308 helicase requires dual functions of a winged helix domain

... winged helix domain 3 (WHD) highlighted in blue. Bound DNA is in orange, and core helicase domains 1, 2 and 4 are in grey (labeled d1, d2 and d5), except for part of RecA-like domain 1 that is ...

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The basic helix loop helix transcription factor Nato3 controls neurogenic activity in mesencephalic floor plate cells

The basic helix loop helix transcription factor Nato3 controls neurogenic activity in mesencephalic floor plate cells

... Repression of Hes1 by Nato3 is not sufficient for conferring neurogenic potential on medial FP cells We next asked whether the neurogenic defect observed in medial mesFP cells in the dre[r] ...

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