Benign breast disease

Top PDF Benign breast disease:

Association between mammographic breast density and histologic features of benign breast disease

Association between mammographic breast density and histologic features of benign breast disease

We also noted a positive association between MBD and CCH/FEA. In the literature, columnar cell lesions have been reported to include changes such as proliferation of columnar shaped epithelial cells within enlarged TDLUs and have been classified with or without atypia [30, 31]. Turasvili et al. conducted a study of histologic features from bilateral subcutaneous mastectomies from forensic autopsy, and reported an association between columnar cell (CC) lesions and radiographic breast density measured as high Faxitron Wolfe density (OR = 2.1, 95% CI 1.01–4.6; p = 0.04) [29]. They also showed that CC lesions are asso- ciated with higher tissue collagen, suggesting that stromal composition and epithelial stromal interaction may poten- tially contribute to the association between CC lesions and breast density. In a study of 282 women with FEA in a co- hort with benign breast disease, FEA has been associated with AH in half the cases, with ADH more commonly so than ALH [25]. Further research is warranted to under- stand the molecular mechanisms underlying early epithe- lial changes in mammary glandular tissue that may provide insight into mechanisms for breast cancer development.
Show more

10 Read more

Adolescent Dietary Vitamin D and Sun Exposure in Relation to Benign Breast Disease

Adolescent Dietary Vitamin D and Sun Exposure in Relation to Benign Breast Disease

Vitamin D deficiency/insufficiency is highly prevalent worldwide; an estimated 1 billion people have 25-hydroxyvitamin D levels below 30 ng/mL. [1] Experimental evidence suggests that vitamin D may be important for breast cancer prevention given its pro- apoptotic and cell differentiation properties, [2] although prospective studies of adult vitamin D exposure and breast cancer risk have been inconsistent.[3] Because adolescence is a period of heightened breast tissue sensitivity to environmental exposures,[4, 5] adolescent vitamin D insufficiency may be related to higher risk of benign breast disease (BBD), a group of breast lesions that develop during young adulthood and are associated with a higher risk of breast cancer.[6] Among 29,480 women in the Nurses’ Health Study II, women in the top quartile of adolescent dietary vitamin D intake had a 21% lower risk of proliferative BBD compared to those in the bottom quartile (HR=0.79; 95% Confidence Interval [CI]: 0.61, 1.01; p-trend = 0.07).[7] Although this study included prospectively reported cases, adult women recalled their adolescent diet, which is subject to measurement error. Also, this study did not include sun exposure, which is the main contributor to serum vitamin D concentrations in most individuals. To our knowledge, no previous prospective study has assessed current vitamin D intake or sun exposure in adolescent girls in relation to BBD risk.
Show more

13 Read more

A Prospective study of Endometriosis and Risk of Benign Breast Disease

A Prospective study of Endometriosis and Risk of Benign Breast Disease

Benign breast disease is an important risk factor for breast cancer. In our analysis, we observed a modest risk of biopsy confirmed BBD, both proliferative and nonproliferative lesions, among women with endometriosis. The strongest increased risk of proliferative BBD in women with endometriosis was observed among women with a history of infertility. Contrary to our a priori hypothesis, we found that endometriosis was associated with an increased risk of both proliferative and nonproliferative lesions. This finding is difficult to interpret given the lack of uniformity for classifying nonproliferative benign lesions across studies. In their seminal study, Dupont and Page found no increased breast cancer risk among women with nonproliferative BBD [12]. However, more recent research has found modest increased risk of breast cancer among nonproliferative lesions [9, 17, 41]. Wang et al. in a companion study to the National Surgical Adjuvant Breast and Bowel Project (NSABP) Breast Cancer Prevention Trail found that women in the “lower category” of BBD had 1.6 times the risk of breast cancer compared to healthy women [41]. Hartman et. al. found that women with nonproliferative BBD had a 1.27 (95% CI: 1.15–1.41) fold risk of breast cancer among a cohort of women from the Mayo Clinic [17]. And most recently, Castells et. al. found nonproliferative lesions conferred a 2.23 fold (95% CI: 1.86–2.68) increased risk of breast cancer in a population based screening cohort [9]. Few studies have investigated risk factors for both proliferative and nonproliferative lesions given the mixed findings among nonproliferative lesions related to breast cancer risk.
Show more

15 Read more

LEVEL AND CONDITIONING OF KNOWLEDGE  IN BENIGN BREAST DISEASE IN VERY YOUNG PATIENTS

LEVEL AND CONDITIONING OF KNOWLEDGE IN BENIGN BREAST DISEASE IN VERY YOUNG PATIENTS

Purpose of the study was to identify individual psychopathological features in young patients suffering from benign breast disease. Participants were interviewed using a structured clinical test (SCID-II, version 2.0) disorders, and the Italian version of Akiskal’s semi-structured clinical interview for temperamental profiles (TEMPS-I) after clinical breast exams and ultrasonography. All patients presented different personality disorders and heterogeneity in temperamental profiles. Of 19 patients recruited, four patients with negative breast exam had istrionic-narcisistic personality; nine patients suffering from fibroadenoma, three patients with breast asymmetry had mainly B group disorders with high prevalence of avoidance and obsessive-compulsive personality. Patients suffering from hematoma and gynecomastia had the C group antisocial disorder. In fibroadenoma, hematoma and gynecomastia cases the temperamental trait is mainly depressive. In breast asymmetry cases and in patients without breast disease, temperamental trait is cyclothymic and irritable. The study demonstrate the significance of psychiatric counselling also for young patients in breast units. Future purpose is to extend the sample and to add a follow-up evaluation.
Show more

7 Read more

A panel containing PD-1, IL-2Rα, IL-10, and CA15-3 as a biomarker to discriminate breast cancer from benign breast disease

A panel containing PD-1, IL-2Rα, IL-10, and CA15-3 as a biomarker to discriminate breast cancer from benign breast disease

Introduction: Programmed cell death protein 1 (PD-1), an immune checkpoint molecule, has recently been recognized as a predictive and prognostic biomarker in several malignant tumors, but its diagnostic value remains largely unknown. We aimed to investigate the differential diagnostic efficiency of PD-1 and other immune molecules and propose a panel of immune molecules combined with cancer antigen 15-3 (CA15-3) to distinguish breast cancer (BC) from benign breast disease (BBD).

13 Read more

Breast fibroadenomas are not associated with increased breast cancer risk in an African American contemporary cohort of women with benign breast disease

Breast fibroadenomas are not associated with increased breast cancer risk in an African American contemporary cohort of women with benign breast disease

Over 1.5 million breast biopsies are pathologically assessed annually in the United States, indicated by ab- normal mammography findings or patient complaints [1]. Most biopsies are not malignant, but instead exhibit a number of pathological lesions that constitute benign breast disease (BBD). Biopsies that exhibit proliferative disease or cellular atypia, as defined by Dupont and Page criteria, are consistently associated with increases in breast cancer risk [2–4]. These pathologic criteria have been included in risk assessment models to identify women at high risk of developing breast cancer. Several current risk assessment models, including the frequently used Breast Cancer Risk Assessment Tool, incorporate information on the number of prior biopsies and the presence of atypia on biopsy, but they do not account for other BBD lesions that may independently increase breast cancer risk [5]. Reliable estimates of breast cancer risk associated with individual lesions can improve risk models, allowing physicians to better identify women at high risk of developing breast cancer who may benefit from additional screening or chemoprevention.
Show more

8 Read more

Adolescent Carotenoid Intake and Benign Breast Disease

Adolescent Carotenoid Intake and Benign Breast Disease

Micronutrient intake was divided into quartiles to allow for nonlinear associ- ations and to minimize the in fl uence of outliers. We used multivariable-adjusted logistic regression to assess carotenoid intake in relation to BBD by using gen- eralized estimating equations to adjust for the nonindependence of sibling clusters. Models were adjusted for age at the baseline questionnaire, family history of breast cancer in mother or aunt (mother ’ s sister), mother ’ s history of BBD, age at menarche, BMI, nulliparity, physical activity, and alcohol intake. Adjusting for family income, region of the country, multivitamin use, height, total caloric intake, and smoking did not change the magnitude of the as- sociations, so these variables were not included in the fi nal models. Tests for trend were assessed by including the median value within each quartile as a continuous variable in the model and calculating the Wald statistic.
Show more

9 Read more

A study of diagnostic accuracy in benign breast disease with special reference to recent diagnostic tools

A study of diagnostic accuracy in benign breast disease with special reference to recent diagnostic tools

Remarkably ultrasound of the breast has been performed both in vitro and clinically for 53 years. The first clinical application of breast ultrasound was reported in 1954 by Wild and Reid. The focus was however clearly on the goal of distinguishing benign and malignant lesions and the results were remarkably accurate in this regard. A major improvement occurred in 1969 with the introduction of grey scale imaging. In the late 1960’s Kelly-fry et al (USA) attempted characterization of known masses with an effort toward early detection of sub clinical lesions. Theirs was the first attempt to identify the different structural elements of the mammary gland.
Show more

75 Read more

Intakes of Alcohol and Folate During Adolescence and Risk of Proliferative Benign Breast Disease

Intakes of Alcohol and Folate During Adolescence and Risk of Proliferative Benign Breast Disease

This study suggests a dose-dependent increase in risk of proliferative BBD with alcohol consumption during ado- lescence and early adulthood, which may not be reduced through increased folate intake. This result, if con fi rmed in studies performed in other populations, indicates that increased folate intake during adolescence may not effectively prevent alcohol-associated breast can- cer. Since alcohol use is common in adolescent girls and young women, 39,40

9 Read more

Prospective Study of Adolescent Alcohol Consumption and Risk of Benign Breast Disease in Young Women

Prospective Study of Adolescent Alcohol Consumption and Risk of Benign Breast Disease in Young Women

women from all over the United States. However, we cannot be certain that ev- ery assessment of alcohol (2003) pre- ceded every BBD diagnosis (for which we have no dates), but it is unlikely that any participant increased her alcohol intake as a result of a BBD diagnosis. Although we controlled for potential confounders (age and BMI in all mod- els and, in some models, age at men- arche, age at which regular drinking began, maternal BBD, and maternal breast cancer), some residual and un- measured confounding may remain. We cannot exclude the possibility of in- complete adjustment of some covari- ates or confounding through variables not considered, but little is known about childhood/adolescent risk fac- tors for BBD. Although our cohort is not representative of US women, asso- ciations among factors within our co- hort should still be valid.
Show more

9 Read more

Association Between Benign Breast Disease in African American and White American Women and Subsequent Triple-Negative Breast Cancer

Association Between Benign Breast Disease in African American and White American Women and Subsequent Triple-Negative Breast Cancer

Until recently, studies that correlate BBD with breast can- cer risk grouped all phenotypes together. Insights regarding the diversity of breast cancer prompted scrutiny of BBD and phenotype-stratified risk. One model of breast cancer patho- genesis suggests that fibrocystic proliferative changes are pre- cursors for relatively more indolent patterns, including ER- positive disease. 3 The Mayo Clinic BBD cohort demonstrated

7 Read more

Role of HGF in epithelial–stromal cell interactions during progression from benign breast disease to ductal carcinoma in situ

Role of HGF in epithelial–stromal cell interactions during progression from benign breast disease to ductal carcinoma in situ

Breast cancer progression requires that epithelial cells acquire capabilities that enhance their growth and sur- vival. While biological models of cancer have tradition- ally emphasized cell-autonomous characteristics, it is clear that changes in the microenvironment are also ne- cessary [8]. Castro and colleagues demonstrated that the stroma of DCIS lesions already possess alterations found in full invasive tumors [39], and Ma and col- leagues and Allinen and colleagues demonstrated that genomic changes occur in many cell populations of the microenvironment [10,11]. These models explicitly hypothesize that epithelial cells must undergo an evolu- tionary adaptation to their microenvironments [1,2,40]. Other models propose that the microenvironment is the driving force of the benign lesion evolution into full in- vasive tumors; Gatenby and Gillies even speculate that the origin of cancer may lie not in mutations within epi- thelial cells, but within acquired or somatic mutation changes in the mesenchymal cells that control tissue structure [41]. While our data do not support these lat- ter models, our data do suggest that progression is not isolated to a single compartment (the epithelium), but rather reflective of epithelium–stroma coevolution. Het- erotypic interactions between epithelium and stroma foster this coevolution by selecting for complementary phenotypes in stroma and epithelium.
Show more

14 Read more

Risk factors associated with Breast Cancer and Benign Breast Disease among women in Eastern India: A Hospital Based Study

Risk factors associated with Breast Cancer and Benign Breast Disease among women in Eastern India: A Hospital Based Study

Breast carcinoma tumors were fixed in 10% neutral-buffered formalin for 24 h, measured the tumor size, nodal status, grade, type of carcinoma and embedded in paraffin, and sectioned. For immunohistochemistry, paraffin sections of tumors were deparaffinized and hydrated by successive washes with xylene, 100% ethanol, and a phosphate buffer [10 mM],(pH 7.4) and 0.138 M saline containing 2.7 mM KCl). Antigen retrieval was accomplished with diluted antigen retrieval buffer (DAKO Corp.) Endogenous peroxidase was blocked with 3% hydrogen peroxide. Subsequently, slides were washed in PBS/KCl, incubated with 10% normal horse serum followed by the primary antibody (rabbit anti-ER antibody or rabbit anti-PR antibody rabbit anti-c-erbB2; HER-2/neu) and incubated overnight at 4°C. The slides were then incubated with biotinylated secondary antibody for 45 min, followed by ABC reagent and diaminobenzidine. Counterstaining was done with hematoxylin. Sections were dehydrated by washing sequentially with 95% ethanol, 100% ethanol, and xylene. Coverslips were mounted on slides using Paramount. Digital images of stained and unstained cells were obtained using an Olympus microscope equipped with a SPOT digital camera.
Show more

6 Read more

Benign breast disease, recent alcohol consumption, and risk of breast cancer: a nested case–control study

Benign breast disease, recent alcohol consumption, and risk of breast cancer: a nested case–control study

cancer cases in both cohorts were identified through the nurses' own reports and were confirmed by review of medical records. Cases in the study are cases of breast cancer diag- nosed by 1 June 1994 (NHS I) or 1 June 1995 (NHS II) with a previous confirmed BBD biopsy and available pathology spec- imens (histologic sections and/or tissue blocks). Controls are women who did not have a diagnosis of breast cancer when the case was diagnosed and also had a previous biopsy-con- firmed BBD and available pathology specimens. Controls were matched to cases on year of birth and year of biopsy. Attempts were made to identify four matched controls for each case, although this was not always possible. This study was approved by the Committee on Human Subjects at Brigham and Women's Hospital.
Show more

8 Read more

Vacuum assisted breast biopsy: A comparison of 11 gauge and 8 gauge needles in benign breast disease

Vacuum assisted breast biopsy: A comparison of 11 gauge and 8 gauge needles in benign breast disease

A correct diagnosis could be made for all 123 patients using VB. No repeat biopsies had to be performed. No biopsies were abandoned during the procedure. Out of the 123 biopsies performed, a total of 46 fibroadenomas, 18 cases of sclerosing adenosis, and 38 cases of fibrocystic mastopathy, 11 cases of scarring following a previous sur- gical procedure, 8 papillomas and 2 cases of other benign histology were diagnosed. All 8 papillomas which were included in the study showed no signs of atypia and were completely removed under sonographic imaging. There- fore open biopsy was not performed after recommenda- tion in an interdisciplinary tumour conference. No residues were found in any of these cases at the follow-up examination. A list of the histological results stratified according to needle size is shown in table 3.
Show more

6 Read more

Association between benign thyroid disease and breast cancer: a single center experience

Association between benign thyroid disease and breast cancer: a single center experience

Differences was observed regarding autoimmune thy- roiditis, with pre-menopausal BC patients being more frequently affected by this pathology than post- menopausal BC patients (45% vs. 29%, p = 0.05). Similar results have been recently published by Chiappa et al. [19], who described an association between chronic autoimmune thyroiditis and BC diagnosed in pre- menopausal state. However, these results may not be completely comparable, since for Chiappa and colleagues post-menopause was defined as women aged > = 45 years instead of 60 years. Anyway, several other studies have shown an association between BC and autoimmune TD [20], although the underlying reasons for this correlation are still unclear. In 2001, Gogas et al. [21] demonstrated a higher frequency of autoimmune thyroiditis in subjects with more advanced BC, therefore suggesting a possible correlation between thyroid autoimmunity and a worse BC prognosis. On the other hand, Smith et al. [22] pub- lished completely different data, giving evidence of a bet- ter prognosis in patients suffering from autoimmune TD. Giustarini et al. [23] evaluated thyroid autoimmun- ity in patients with malignant and benign breast diseases before surgery and observed a significantly higher pres- ence of thyroid antibodies in BC patients compared to patients suffering from benign breast disease. Recently, Muller et al. [24] found no difference in terms of 10- year survival for BC patients with or without thyroid antibodies at blood tests analysis.
Show more

8 Read more

Benign Breast Diseases (Non Inflammatory): An Analytical study

Benign Breast Diseases (Non Inflammatory): An Analytical study

There is no completely satisfactory classification of benign breast disease. Previous attempts have been based on number of factors as clinical symptoms, age of the patient, histological features or that part of the secretary system in which the abnormality has risen. They all have inherent disadvantages. Firstly there is poor correlation between clinical, pathological and radiological features in any particular disease. Secondly benign breast disorders encompass a wide spectrum of clinicopathologial features ranging from near normality to severe disease. Finally the breast must be regarded as a physiologically dynamic structure in which cyclical variations are superimposed on changes of development and involution throughout the women’s life. These physiological changes themselves may be so extensive that they may fall outside what is regarded as the normal spectrum.
Show more

81 Read more

EVALUATION OF OXIDATIVE STRESS AND ANTIOXIDANTS IN PATIENTS WITH BENIGN AND MALIGNANT BREAST DISEASE

EVALUATION OF OXIDATIVE STRESS AND ANTIOXIDANTS IN PATIENTS WITH BENIGN AND MALIGNANT BREAST DISEASE

Increasing epidemiological studies have shown involvement of reactive oxygen species in the development of cancer in human, [17] Low levels of oxygen free radicals have been reported to stimulate cell proliferation whereas high levels induce mutagenicity, cytotoxicity and cell death. [18] MDA is considered as a marker of oxidative stress and is one of the frequently used parameter for measurement of free radical induced cellular damage.. Among the study group, MDA levels were increased in breast cancer and benign breast disease patient as compared to control group,but breast cancer has highest level of serum MDA levels. This difference was statistically significantThe damage induced by lipid peroxidation renders the cell unstable, compromises fluidity,permeability of membranes, signal transduction, nuclear alteration. [19] Thus ROS have role in pathogenesis of breast cancer.
Show more

14 Read more

Abstract Background: Benign breast lesions are the most common breast disease in females. This study was

Abstract Background: Benign breast lesions are the most common breast disease in females. This study was

From the present study it is concluded that benign breast disease is most commonly seen in the age group of 21 to 30 years and majority of the patients present with breast lump followed by breast lump and pain. Fibroadenoma is the most common benign breast lesion encountered in clinical practice followed by fibroadenosis. Benign breast lesions are more common in the right breast and upper outer quadrant is mostly involved. Triple assessment provided a quick diagnosis and it alleviated unnecessary anxiety from the patients about breast cancer.
Show more

5 Read more

The spectrum of benign breast lesions – A study in Tertiary Care Hospital

The spectrum of benign breast lesions – A study in Tertiary Care Hospital

Benign Breast Disease is primarily seen in the reproductive period of life. They are largely hormone- induced. So that after menopause and cessation of ovulation, a dramatic decrease in the incidence is seen. The study aimed to find the incidence of benign breast diseases presenting to our Tertiary Care Hospital. Methods: This cross-sectional prospective study was done in the Department of General Surgery, Prathima Institute of Medical Sciences, Karimnagar. A detailed history including Age, Marital status, Socio-economic status, Occupation, history presenting complaints, menstrual history, and the relation of complaints to menstruation was done. Obstetric history, Lactation history, number of babies fed, past history of similar complaints, family history, and personal history was obtained. All the information was noted down in the proforma designed for the study. The following investigations were done complete blood picture, USG breast/mammogram, FNAC, and Histopathological examination. Results: The most common presentation was a lump in the breast 84% of patients were with this clinical finding. There was pain associated with a lump in 56% cases and 12% had only pain and pain, lump and fever were found in 12%. In the present study of 50 cases of benign breast, the disease was studied in which Fibroadenoma constituted 40% (n=20 cases). Fibroadenomas with fibrocystic diseases constituted 24% (n=12 cases). Phylloid tumor (Cystosarcoma phyllodes) constituted 12% (n=6cases). Breast abscess constituted 12% (6 cases). Mastitis 8% (n=4 cases) and Galactocele constituted 4% (n=2 cases). Conclusion: Benign breast lesions are very common in females. A painless lump in the breast may be the finding. In some cases, lumps may be present with pain or there may be nipple discharge. The younger females are more likely to have benign breast lesions. Fibroadenoma was the benign lesion found in the study. The accuracy of diagnosis was best by histopathology examination. Early diagnosis and proper treatment will prevent morbidity and mortality due to malignant changes in some lesions.
Show more

5 Read more

Show all 10000 documents...