Bradykinin B2 receptor
In vivo bradykinin B2 receptor activation reduces renal fibrosis
... that bradykinin is involved in the control of a wide range of physiological functions, including car- diovascular homeostasis (regulation of systemic blood pressure and organ blood flow), water and electrolyte ...
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Novel signaling of dynorphin at κ opioid receptor/bradykinin B2 receptor heterodimers
... 5-HT2A receptor agonists activate both Gq and Gi proteins when the 5-HT2A receptor forms heteromers with the mGlu2 receptor [58, ...orexin receptor 1 and KOR can form a heterodimer, which ...
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The relationship of Bradykinin B2 receptor gene variation with obesity, hypertension and lipid variables in obese patients
... al. Bradykinin enhances GLUT4 translocation through tha increase of insulin re- ceptor tyrosine kinase in primary adipocytes: evidence that bradykinin stimulates the insulin signalling ...dykinin ...
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Infrared emitting, peptidase resistant fluorescent ligands of the bradykinin B2 receptor: application to cytofluorometry and imaging
... Background: We have previously reported the design, pharmacological properties and imaging application of brad‑ ykinin (BK) B 2 receptor (B 2 R) ligands conjugated with fluorophores such as fluorescein derivatives ...
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Administration of angiotensin II and a bradykinin B2 receptor blocker in midpregnancy impairs gestational outcome in guinea pigs
... At the level of the utero-placental unit, tilting the RAS/ KKS balance towards vasoconstriction caused fetal losses and placental insufficiency, and reduced the replacement of endothelium by endovascular trophoblasts in ...
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Gender-related associations of genetic polymorphisms of α-adrenergic receptors, endothelial nitric oxide synthase and bradykinin B2 receptor with treadmill exercise test responses
... cardiovascular performance during exercise testing. Therefore, we evaluated associations between functional genetic polymorphisms of α -adrenergic receptors, endothelial nitric oxide synthase, bradykinin ...
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The BRAIN TRIAL: a randomised, placebo controlled trial of a Bradykinin B2 receptor antagonist (Anatibant) in patients with traumatic brain injury
... formation. Bradykinin (BK), an inflamma- tory mediator in the kinin-kallikrein system, may contribute to cerebral oedema by increasing permeability of the ...
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Wennerberg, Göran (2010): Role of the intracellular domains in the regulation and the signaling of the human bradykinin B2 receptor. Dissertation, LMU München: Medizinische Fakultät
... Confluent cells were washed twice with ice cold PBS and subsequently incubated with 0.3 mg/ml disulfide-cleavable sulfo-NHS-SS-Biotin (Pierce) in PBS for 30 min at 4°C. After rinsing twice with ice cold Tris-buffered ...
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The design and synthesis of non-peptide bradykinin B2 receptor antagonists
... Kinins perform many important physiological roles. In the digestive system BK is a major agent of intestinal motility^^. It is also a regulator of chloride ion transport in the intestine and, as such, is important in ...
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Senescence associated phenotypes in Akita diabetic mice are enhanced by absence of bradykinin B2 receptors
... the bradykinin B2 receptor increases the severity of a variety of senescence-associated changes that occur in untreated diabetic ...the B2 receptor on TBARSs and GSH were both highly ...
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Hereditary angioedema: what the gastroenterologist needs to know
... a bradykinin B2-receptor antagonist, or a kallikrein inhibitor as first-line therapy and solvent/detergent-treated or fresh frozen plasma as second-line therapy for acute ...
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α1-ADRENORECEPTORS AND ANGIOTENSIN RECEPTORS
... AT1 receptor, ...AT2 receptor has become unraveled over the last few years owing to various sophisticated approaches including gene transfection and ...AT2 receptor counterbalances the effect of the ...
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Nociceptive tolerance is improved by bradykinin receptor B1 antagonism and joint morphology is protected by both endothelin type A and bradykinin receptor B1 antagonism in a surgical model of osteoarthritis
... Antagonism of ETA and/or BKB1 may represent a novel therapeutic option to alleviate, and perhaps prevent or reverse, the pain, inflammation, and tissue damage that occur as OA progresses from an acute to a chronic state. ...
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Mechanisms of hyperresponsiveness in the human nasal airway: Role of kinins and nitric oxide
... Interestingly, experimental induction of allergic rhinitis in susceptible individuals, using exogenous antigen under controlled conditions, has demonstrated a number of differences between the two different forms of ...
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Journal of Applied Pharmaceutical Science
... Binding Site analysis is a fast detection program for the identification and visualization of possible binding sites and the distribution of surrounding residues in the active sites. The centre of active site was chosen ...
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Bradykinin increases resensitization of purinergic receptor signaling in glioma cells
... with bradykinin application was also preserved in 0 Ca 2+ medium, although a significantly smaller peak amplitude (39% average resensitization in 0 Ca 2+ ...
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Exploring the Horizons of Ephrin B2 Receptor for Combating Paramoxyviridae Infection
... The Hendra and Nipah viruses (HeV and NiV) are prominant members of the Paramyxoviridae family [1]. The initial cases were detected in Australia in 1994-95 and Malaysia in 1998-99. Henipa viruses have been transmitted to ...
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Fibroblast like synovial cells from normal and inflamed knee joints differently affect the expression of pain related receptors in sensory neurones: a co culture study
... The present study addresses the regulation of receptors in DRG neurones that are involved in the generation of inflamma- tory pain and hyperalgesia. Substance P sensitises joint affer- ents for mechanical stimuli, thus ...
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The role of contact system in septic shock: the next target? An overview of the current evidence
... for bradykinin-1-receptors between humans and mouse, rat, rabbit, and dog are, respectively, 68, 71, 78, and ...For bradykinin-2-receptors, interspecies homology is greater, being 82, 81, ...for ...
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Original Article Effect of bradykinin on cultured retinal pigment epithelial cells
... BK receptor antagonist group with the BK group, inhibiting B1R alone did not influence the collagen decrease, how- ever, inhibiting B2R alone did reduce the colla- gen decrease, which suggested B2R was more ...
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