brain delivery
Intracellular delivery mechanism and brain delivery kinetics of biodegradable cationic bovine serum albumin-conjugated polymersomes
... the brain delivery kinetics of poly- mersomes after conjugation with ...rat brain in a time- dependent manner and conjugation of polymersomes with CBSA significantly improves their transcytosis ...
12
Development of coated liposomes loaded with ghrelin for nose-to-brain delivery for the treatment of cachexia
... Abstract: The aim of the present study was to develop a ghrelin-containing formulation based on liposomes coated with chitosan intended for nose–brain delivery for the treatment of cachexia. Among the three ...
13
Applications of dendrimers for brain delivery and cancer therapy
... Magnetic delivery systems have been widely investigated for the targeted delivery of ...novel brain-targeted bi- functional gene delivery system based on natural magnetic particles, called ...
42
Brain delivery of vasoactive intestinal peptide (VIP) following nasal administration to rats
... the brain, the drugs reaching the brain parenchyma mainly by a paracellular route (Mathison et ...For brain delivery, a VIP analogue was conjugated to the OX26 monoclonal murine antibody ...
11
The nasal delivery of nanoencapsulated statins – an approach for brain delivery
... suspension of simvastatin was used as a control. It is worth pointing out that the radioactivity that is detected cannot be considered permanently bound to the particles or to the drug molecule. However, it appears clear ...
16
Surface-Modified Nanocarriers for Nose-To-Brain Delivery: From Bioadhesion to Targeting
... nasal sheep mucosa and improved brain accumulation of the drug in comparison to drug solution. 692[r] ...
33
NOSE TO BRAIN DELIVERY OF ZIPRASIDONE MICROEMULSION: DESIGEN AND CHARACTERIZATION
... drug delivery. On the basis of systemic delivery, the microemulsion formulation is used for rapid onset of action for insoluble ...nasal delivery but it gives action after long period of time or no ...
8
A Review on Novel Techniques for Drug Delivery to the Brain
... Consequently, brain delivery of diverse drugs, including antifungals, chemotherapeutic compounds, anti-retrovirals, anti-epilepsy drugs and anti-ischemia drugs by liposomal formulations has been studied ...
8
Transferrin and the transferrin receptor for the targeted delivery of therapeutic agents to the brain and cancer cells
... gene delivery systems, since it is non-toxic, non- immunogenic and biodegradable ...the brain capillary endothelium which forms the blood-brain barrier (BBB) in conjugation with other cellular ...
43
Targeted Nanoparticle Delivery of Therapeutics Across the Blood-Brain and Blood-Tumor Barriers to Breast Cancer Brain Metastases
... enable brain delivery of circulating ...the brain. This procedure has been shown to improve delivery of therapeutics to brain tumors, and has been used most successfully for primary ...
172
Brain targeting drug delivery system
... drug delivery systems consists of G3 polyamidoamine and surfactant conjugated dendritic nano conjugate successfully applied for targeted brain delivery ...
11
Current Strategies for Brain Drug Delivery
... the brain side ...the brain by actively targeted nanoparticles is ...prepare brain-targeted Pluronic-based nanoparticles and demonstrated enhanced brain delivery following intravenous ...
13
Getting into the brain: liposome-based strategies for effective drug delivery across the blood–brain barrier
... drug delivery across the blood–brain ...drug delivery and in vivo bioimaging for the treatment and/or diagnosis of neurological diseases, such as Alzheimer’s, Parkinson’s, stroke, and ...the ...
34
POLYMER -LIPID HYBRID NANOPARTICLES FOR BRAIN TARGETING THROUGH INTRANASAL DELIVERY
... to brain delivery of carbamazepine which can be advantageous for other CNS active drugs which shows side effects by oral or intravenous ...the brain from nasal ...
8
Development of nanoemulsion for efficient brain parenteral delivery of cefuroxime: designs, characterizations, and pharmacokinetics
... The untreated plasma samples and brain homogenate were used to prepare 0.5, 1.0, 5.0, 10.0, 15.0, 30.0, and 50.0 µ g/mL standard concentrations of cefuroxime. Cooled acetonitrile was used as the deproteinization ...
14
<p>Targeted delivery of polypeptide nanoparticle for treatment of traumatic brain injury</p>
... targeted delivery of Tat-NR2B9c to the brain for TBI treatment through surface conjugation of CAQK, a four- amino acid peptide that was reported to have high af fi nity with extracellular matrix at the site ...
11
Current approaches to enhance CNS delivery of drugs across the brain barriers
... single-phase solution by titrating a milky emulsion with hexanol. A microemulsion is defined as a system of water, oil, and amphiphile, which is a single optically isotropic and thermodynamically stable liquid solution. ...
17
Transcranial optical imaging reveals a pathway for optimizing the delivery of immunotherapeutics to the brain
... whole brain images were acquired for CSF trac- er (BSA-647) on a stereomicroscope (MVX10, Olympus) at ×16 ...animal. Brain sections were mounted with ProLong Gold Antifade with DAPI (Invi- trogen) and with ...
16
Immunological Aspects of Recombinant Adeno-Associated Virus Delivery to the Mammalian Brain
... may evoke on a host immune response. Therefore, rAAV of serotypes 5 and 2 with identical expression cassettes containing EGFP were coinjected 2 weeks apart, and autofluorescence of EGFP was determined 4 weeks after the ...
9
Peptides and proteins used to enhance gold nanoparticle delivery to the brain: preclinical approaches
... the delivery of AuNPs to the brain, the AuNPs can be coated with peptides or proteins that can cross the BBB using different physiological mechanisms (AMT or ...
18