brain endothelium
MicroRNA-155 contributes to shear-resistant leukocyte adhesion to human brain endothelium in vitro
... human brain endothelium. In this study, we show that modulation of brain endothelial miR-155 levels led to significant changes on firm T cell and monocytic cell line adhesion to hCMEC/D3 ...to ...
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Th17 Cells Interactions with the Brain Endothelium in Vitro
... the brain endothelium, effector cells such as Th17, transmigrate to the brain parenchyma to initiate inflammatory ...stimulated brain endothelial cells produce chemokines CCL2 and CXCL1, but ...
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Group B streptococcal β hemolysin/cytolysin activates neutrophil signaling pathways in brain endothelium and contributes to development of meningitis
... BBB endothelium to produce targeted recruit- ment and activation of neutrophils in response to the initial bacterial encounter may be an important adap- tation, since a wider or unchecked pattern of inflam- matory ...
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Expression and localization of claudins-3 and -12 in transformed human brain endothelium
... human brain endothelium and other non-endothelial based cell ...primary brain endothelium (PHB, lane 1) and trans- formed (hCMEC/D3, lane ...the brain endothelial cells (lanes 1, ...
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MiR-126 and miR-126* regulate shear-resistant firm leukocyte adhesion to human brain endothelium
... that brain endothelial miR-126 overexpression decreased both healthy donor and MS-derived PBMC firm adhesion to cytokine-treated hCMEC/D3 cells by 50–60% in all samples tested ...
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Transport of Gold Nanoparticles by Vascular Endothelium from Different Human Tissues
... cross brain endothelium in vitro via the cyto- solic route ...in brain microvas- cular endothelium, primarily in the ...the brain at speeds up to 1μm per ...
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α4 integrin VCAM 1 binding mediates G protein–independent capture of encephalitogenic T cell blasts to CNS white matter microvessels
... on brain endothelium in vitro (5), and lymphocytes bind via α 4/VCAM-1 to inflamed cere- bral vessels in a modified Stamper-Woodruff frozen sec- tion adhesion assay ...the brain and spinal cord ...
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Impairment of brain endothelial glucose transporter by methamphetamine causes blood-brain barrier dysfunction
... in brain endothelium, resulting in disruption of BBB integrity and endothelial cell ...the brain endothelium by donating an acetyl group to glucosamine so as to keep the acetylglucosamine ...
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Impact of altered glycaemia on blood-brain barrier endothelium: an in vitro study using the hCMEC/D3 cell line
... HCMEC/D3 cells were co-cultured with juxtaposed human astrocytes (ScienCell Research Laboratories, San Diego, CA, USA) grown on the abluminal side of semipermeable Transwell® inserts [16,23]. The Transwell® apparatus ...
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Elevated circulating free fatty acid levels impair endothelium dependent vasodilation
... on endothelium-dependent vasodilation was comparable to the effect of exogenously elevated FFA levels in both low- and high-dose FFA ...of endothelium-dependent ...in endothelium-dependent vasodi- ...
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Tumor necrosis factor receptor superfamily member 9 is upregulated in the endothelium and tumor cells in melanoma brain metastasis
... melanoma brain metastasis (blue ...melanoma brain metastasis (asterisk) exhibit strong ...melanoma brain metastasis (asterisk) also display membranous ...melanoma brain metastases showed ...
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Impact of wall shear stress and ligand avidity on binding of anti-CD146-coated nanoparticles to murine tumor endothelium under flow
... as a correlate of shear stress in dilated tumor vessels. CD146 was used as ligand on the endothelial surface for nanoparticle capture. It has been shown in previous work [13] and confirmed in this study that this ...
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Role of tissue C4d in differentiation between acute rejection and HCV recurrence after living donor liver transplantation
... Tissue C4d staining by IHC technique was almost present in rejection cases only, where it had high specificity and positive predictive value in diagnosis of rejection. There was agreement between histopathological ...
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Cytotoxic mAb from rheumatic carditis recognizes heart valves and laminin
... To localize the mAb 3.B6 epitope(s) in HCM, S1 and HMM subfragments, and LMM, peptides were reacted with mAb 3.B6. S1 and HMM subfragments reacted with mAb 3.B6 in the ELISA (Figure 3a), suggesting that mAb 3.B6 ...
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In vitro vasorelaxation mechanisms of bioactive compounds extracted from Hibiscus sabdariffa on rat thoracic aorta
... mainly endothelium-dependent relaxant effects. The endothelium-dependent relaxations result from NOS activation and those who not dependent to endothelium from activation of smooth muscle potassium ...
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NANOPARTICLES AS SPECIFIED CARRIERS IN TARGETED BRAIN DRUG DELIVERY SYSTEM
... the brain against toxic substances that circulate in the ...the brain, the existence of the BBB is a severe limitation for the delivery of most drugs to the brain because they do not cross the BBB in ...
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Shear Forces Enhance Toxoplasma gondii Tachyzoite Motility on Vascular Endothelium
... the endothelium, as has been previously reported (25), or transmigrating across the endothelial barrier via a paracellular or transcellular ...the endothelium for 1 to 2 min, and a Y-valve connector was ...
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The Vascular Endothelium and Human Diseases
... tion of ROS (78); and high-fat meals, with impaired endothelium-dependent vasodilation (79). A crucial negative effect of such meals is particularly attributa- ble to high levels of circulating free fatty acids, ...
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Local modulation of pulmonary vascular function
... Recent evidence has suggested a role for CO as a neuronal m essenger (Bredt et al. 1990; B redt and Snyder 1994a; Verm a et al, 1993). Solom on H. Snyder and his group have dem onstrated discrete localization’s o f H O-2 ...
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Heterogeneity and emergent behaviour in the vascular endothelium
... The endothelium regulates virtually every cardiovascular activity by releasing numerous vasoactive ...pressure, endothelium- derived nitric oxide and prostacyclins promote vasodila- tion, whereas production ...
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