brain lipid-binding protein
The impact of RASopathy-associated mutations on CNS development in mice and humans
... increased brain to body weight ratio caused by the enlarged cortex [85, ...between brain structural abnormalities and cogni- tive impairments in animal models and those seen in NF1 patients ...a ...
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Development and Application of Lipid Nanotechnology on Infectious Diseases of CNS- Current Scenario
... Blood brain barrier; ABC: ATP- binding cassette; ATP: Adenosine triphosphate; P-gp: Permeability glycoprotein; BCRP: Breast cancer resis- tance protein; MRP: Mitochondrial RNA processing; DADLE: ...
11
Pharmacological Inhibition of Brain Fatty Acid Binding Protein Reduces Ethanol Consumption in Mice
... are lipid retrograde messengers that activate cannabinoid type 1 receptors (CB1Rs), ubiquitously expressed in the brain, including brain areas involved in the regulation of reward ...the brain ...
7
Inhibition of HIV Replication by Apolipoprotein A I Binding Protein Targeting the Lipid Rafts
... disrupt lipid rafts (1, 5, 7, 8) and on the role of rafts in HIV fusion (33); concurrent effects of AIBP on rafts and HIV fusion were demonstrated in several independent experimental systems throughout this ...of ...
20
Spira, Felix (2012): Spatio-temporal organisation of plasma membrane proteins in budding yeast. Dissertation, LMU München: Fakultät für Biologie
... PM. Protein sequences were obtained from uniprot ...on lipid anchors was obtained from the Uniprot sequence annotations as well as prediction tools (Maurer-Stroh et ...2008). Protein abundance values ...
183
Regulation and structure/function relationships of the Rac1 GTPase-activating protein, n-chimaerin
... for binding diacylglycerol rather than phorbol esters (Sakane et a l , 1990; Ahmed et a l , ...the lipid-binding regulatory domain o f PKC (Quest et a l , ...
278
The minor matrix protein VP24 from Ebola virus lacks direct lipid-binding properties
... VP24 lipid-binding may be more dependent on mammalian cell expression due to potential post-translational modifications (PTMs) that may alter VP24-lipid ...fluorescent protein (EGFP) tagged ...
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The role of species specific modifications in peptidoglycan biosynthesis
... a Lipid II analogue (Huang et ...The binding of two Lipid II molecules, one in the donor and one in the acceptor site initiates transglycosylation, involving the interaction with several specific ...
391
Joining the in vitro immunization of alpaca lymphocytes and phage display: rapid and cost effective pipeline for sdAb synthesis
... cell binding domain of OspA of Borrelia) in the presence of recom‑ binant alpaca interleukins 2 and 4, construction of sdAb phage library, selection of antigen specific sdAb expressed on phages (biopanning) and ...
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Detrimental role for CCAAT/enhancer binding protein δ in blood borne brain infection
... murine brain homogenates using TriPure reagent (Sigma-Aldrich, St-Louis, MO, ...octamer binding pro- tein (NoNo, housekeeping gene), primers were described previously ...
6
The Bacterial DNA Binding Protein MatP Involved in Linking the Nucleoid Terminal Domain to the Divisome at Midcell Interacts with Lipid Membranes
... the protein to recognize neutral ...coli lipid mixture contains negatively charged phospholipids (phosphatidylglycerol and cardiolipin [25]), while given its high pI, MatP would be positively charged at ...
14
Characterization of the relationship between the chaperone and lipid-binding functions of the 70-kDa heat-shock protein, HspA1A
... total lipid) composed of different lipid mixtures in a specified molar ratio (see figure) was incubated with 1 μM of ...of lipid-protein binding was determined by comparing the amount ...
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AN IN VITRO INVESTIGATION OF AMELIORATIVE EFFECT OF SYNTHETIC AND HERBAL ANTIOXIDANTS ON LEAD INDUCED NEUROTOXICITY
... The main objective in undertaking this in vitro study was to elucidate the mechanism of lead toxicity through alteration in lipid peroxidation, enzyme activities and protein levels in goat brain to ...
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The Role of Macrophage Migration Inhibitory Factor in Alzheimer’s Disease
... β protein (A β ), the essential molecule for the formation of toxic oligomers and, subse- quently, Alzheimer plaques, has been associated in vivo with the immune modulator, macrophage migration inhibitory factor ...
6
Vaccinia virus immunomodulator A46 : a lipid and protein binding scaffold for sequestering host TIR domain proteins
... ligand binding; nev- ertheless, a survey of the hits revealed recurring instances of carbohydrate binding proteins, proteins forming pores and participating in the proper insertion of periplasmic proteins ...
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Hepatitis B Virus X Protein Induces Hepatic Steatosis by Enhancing the Expression of Liver Fatty Acid Binding Protein
... transport and utilization (12) and is also involved in the modula- tion of mitosis (13), cell growth, and differentiation (14). Studies in HepG2 cells suggested that the overexpression of FABP1 mark- edly increased the ...
12
Characterization of the Relationship between the Chaperone and Lipid-Binding Functions of the 70-Kda Heat-Shock Protein, HspA1A
... is lipid-driven, it is imperative to characterize the lipid-binding regions of HspA1A and the relationship between the chaperone and lipid-binding functions of HspA1A, which remain ...
11
An evaluation of the brain distribution of [11C]GSK1034702, a muscarinic-1 (M1) positive allosteric modulator in the living human brain using positron emission tomography
... The main goal of early phase drug development is the demonstration of substantial target engagement at doses which are safe and tolerable and the determination of a therapeutic dose range. Positron emission tomography ...
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Rat lung contains a developmentally regulated manganese superoxide dismutase mRNA binding protein
... RNA-binding protein was recently reported (Clerch, ...whether protein in rat lung extract would bind to 32P-labeled MnSOD ...lung protein forms specific complexes with a 216 b fragment of the ...
5
The HIV-1 Nucleocapsid Protein Recruits Negatively Charged Lipids To Ensure Its Optimal Binding to Lipid Membranes
... from binding reactions of the GagMA and GagNC domains with both the gRNA and the ...These binding events associated with conformational changes could thus control the Gag assembly process at the ...the ...
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