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C5a receptor expression

Increased C5a receptor expression in sepsis

Increased C5a receptor expression in sepsis

... C5aR expression in the brain is increased following closed head injury ...C5aR expression in vari- ous organs during the development of sepsis in mice, since our recent work suggests in CLP rats that ...

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Neuroprotective effects of intravenous immunoglobulin are mediated through inhibition of complement activation and apoptosis in a rat model of sepsis

Neuroprotective effects of intravenous immunoglobulin are mediated through inhibition of complement activation and apoptosis in a rat model of sepsis

... As in our previous experimental trials, we used two different types of immunoglobu- lin preparations (IgG and IgGAM) that are available in clinical practice. Both in vivo and in vitro trials in sepsis immunology ...

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Expression of the C5a receptor (CD88) on granulocytes and monocytes in patients with severe sepsis

Expression of the C5a receptor (CD88) on granulocytes and monocytes in patients with severe sepsis

... granulocyte C5a receptor expression has been demonstrated in patients at the time when the diagnosis of severe sepsis or septic shock can be clinically ...CD88 expression and its correlation ...

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Complement anaphylatoxin C5a neuroprotects through regulation of glutamate receptor subunit 2 in vitro and in vivo

Complement anaphylatoxin C5a neuroprotects through regulation of glutamate receptor subunit 2 in vitro and in vivo

... GluR2 expression in vivo in response to KA when compared to WT ...GluR2 expression using GluR2 ...the expression of GluR2 immunoreactivity in the mossy fiber region of C5aRKO mice ...

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Synergistic interaction between C5a and NOD2 signaling in the regulation of chemokine expression in RAW 264 7 macrophages

Synergistic interaction between C5a and NOD2 signaling in the regulation of chemokine expression in RAW 264 7 macrophages

... polis, MN), Syntaxin-6 (BD Transduction Laboratories, San Diego, CA), heat shock protein 70 (HSC70) (Santa Cruz Biotechnology), phospho-AKT (cell signaling), phospho-p38 (Santa Cruz Biotechnology), phospho- ERK1/2 (cell ...

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Role of the complement system in the tumor microenvironment

Role of the complement system in the tumor microenvironment

... unveiled novel opportunities for the improved man- agement of cancer patients. There is some evidence indicating the therapeutic possibility of complement components as biomarkers or targets for immunothera- pies. Serum ...

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Microglia in Alzheimer’s disease

Microglia in Alzheimer’s disease

... Under physiological conditions, microglia retain a neural-specific phenotype (82) and remain in a relatively quiescent state due to mutual exchange of neuronal and astrocytic signals (83, 84). Neuron- microglial ...

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Complement C5a Receptor 1 Exacerbates the Pathophysiology of N  meningitidis Sepsis and Is a Potential Target for Disease Treatment

Complement C5a Receptor 1 Exacerbates the Pathophysiology of N  meningitidis Sepsis and Is a Potential Target for Disease Treatment

... IMPORTANCE The devastating consequences of N. meningitidis sepsis arise due to the rapidly arising and self-propagating inflammatory response that mobilizes antibacterial defenses but also drives the immunopathology ...

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The complement system in glioblastoma multiforme

The complement system in glioblastoma multiforme

... Secondly, through C3aR and C5aR interaction on the GSC, complement may provide for additional signal trans- duction pathways for PI3K- or mitogen-activated protein kinase (MAPK)/ERK1/2-dependent HIF-1α protein transla- ...

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In vivo clearance and tissue distribution of C5a and C5a des arginine complement fragments in rabbits

In vivo clearance and tissue distribution of C5a and C5a des arginine complement fragments in rabbits

... response observed with both mediators. Clearance of the mediators was primarily seen in the highly vascularized organs: the lung, spleen, liver, and kidney. A time-dependent accumulation was seen initially in the lung, ...

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Prevention of C5aR1 signaling delays microglial inflammatory polarization, favors clearance pathways and suppresses cognitive loss

Prevention of C5aR1 signaling delays microglial inflammatory polarization, favors clearance pathways and suppresses cognitive loss

... of C5a, it remains to be seen if it is the insult of C5a-mediated effects that directly results in the behav- ioral/cognitive dysfunction or if C5aR1 signaling influ- ences synaptic pruning at the ...

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C5a2 can modulate ERK1/2 signaling in macrophages via heteromer formation with C5a1 and beta-arrestin recruitment

C5a2 can modulate ERK1/2 signaling in macrophages via heteromer formation with C5a1 and beta-arrestin recruitment

... proteins C5a and C5a-des Arg bind to two G-protein coupled receptors (GPCR); namely the C5a receptor (C5a1) and C5a receptor like-2 receptor (C5a2, formerly called ...that ...

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Effects of fibrinogen derivatives upon the inflammatory response  Studies with human fibrinopeptide B

Effects of fibrinogen derivatives upon the inflammatory response Studies with human fibrinopeptide B

... for C5a, LTB4, or fMLP as (a) desensitization with 10(-7) M hFpB abolished chemotaxis to hFpB but had no effect upon chemotaxis to C5a, LTB4, or fMLP and (b) induction of chemotactic responses to fMLP and ...

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Effects of anti C5a antibodies on the adult respiratory distress syndrome in septic primates

Effects of anti C5a antibodies on the adult respiratory distress syndrome in septic primates

... develop decreased oxygenation (P less than 0.05) or increased extravascular lung water (P less than 0.05). They also had a marked recovery in their mean arterial blood pressure (P less than 0.05). This study demonstrates ...

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Differential effects of the complement peptides, C5a and C5a des Arg on human basophil and lung mast cell histamine release

Differential effects of the complement peptides, C5a and C5a des Arg on human basophil and lung mast cell histamine release

... where C5a was a potent histamine release stimulus. Supernatants from C5a-challenged mast cells remained fully active on basophils, excluding carboxypeptidase inactivation of C5a as an explanation for ...

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Attachment of human C5a des Arg to its cochemotaxin is required for maximum expression of chemotactic activity

Attachment of human C5a des Arg to its cochemotaxin is required for maximum expression of chemotactic activity

... deglycosylated C5a des Arg, native C5a, or ...native C5a des Arg. Sialic acid also prevented the formation of C5a des Arg-cochemotaxin complexes, detected by acid polyacrylamide gel ...

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Biocompatibility assessment of silk nanoparticles : hemocompatibility and internalization by human blood cells

Biocompatibility assessment of silk nanoparticles : hemocompatibility and internalization by human blood cells

... (CD11b expression) and complement (C5a) activation than was observed in the blank control, whereas native and aminated silica nanoparticles at this concentration induced activation levels similar to the ...

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Complement component 5 contributes to poor disease outcome in humans and mice with pneumococcal meningitis

Complement component 5 contributes to poor disease outcome in humans and mice with pneumococcal meningitis

... Pretreatment model of C5-Ab. To confirm the activity of C5-Ab, we first treated animals with i.p. C5-Ab (n = 7) or i.p. IgG (n = 12) prior to infection. After 24 hours, expression of the TCC C5b-9 was determined ...

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C5a receptor (CD88) promotes motility and invasiveness of gastric cancer by activating RhoA

C5a receptor (CD88) promotes motility and invasiveness of gastric cancer by activating RhoA

... C5aR expression. An invasion assay revealed that C5a stimulation promoted the invasive ability of MKN1 and MKN7 cells and that this was suppressed by knockdown of C5aR using siRNA or a ...after C5a ...

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The C5a anaphylatoxin receptor CD88 is expressed in presynaptic terminals of hippocampal mossy fibres

The C5a anaphylatoxin receptor CD88 is expressed in presynaptic terminals of hippocampal mossy fibres

... This expression was also found on doublecortin-positive cells within the sub-ventricular zone (the primary site of neu- rogenesis in the rodent brain) and rostral migratory stream ...that C5a acts as a ...

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