Ca2+/calmodulin kinase II
Linkage of β1 adrenergic stimulation to apoptotic heart cell death through protein kinase A–independent activation of Ca2+/calmodulin kinase II
... was detected by Western blot using a site-specific anti- body (Badrilla, West Yorkville, United Kingdom). Total CaMKII protein abundance was assayed by Western blot using an antibody reacting with total CaMKII (Santa ...
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Calmodulin kinase II–mediated sarcoplasmic reticulum Ca2+ leak promotes atrial fibrillation in mice
... Blood Institute (NHLBI) grant (R01-HL089598), and a March of Dimes grant (MOD24172). M.G. Chelu is the recipient of the Michael Bilitch Fellowship in Cardiac Pacing and Electrophysi- ology, 2007–2008, from the Heart ...
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Ca2+/calmodulin dependent protein kinase II regulates cardiac Na+ channels
... In heart failure (HF), Ca 2+ /calmodulin kinase II (CaMKII) expression is increased. Altered Na + channel gating is linked to and may promote ventricular tachyarrhythmias (VTs) in HF. ...
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Investigation of neuronal cell type-specific gene expression of Ca2+/calmodulin-dependent protein kinase II
... The promoter activity of the rat Ca 2+ /calmodulin-dependent protein kinase II gene was analyzed using the luciferase reporter gene in neuronal and non-neuronal cell lines. Neuronal cell ...
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Eph and NMDA receptors control Ca2+/calmodulin dependent protein kinase II activation during C elegans oocyte meiotic maturation
... The maturation rates of unc-43(e408) and unc-43(n1186) null hermaphrodites are slightly slower than the wild-type rate, raising the possibility that unc-43 is a positive regulator (Table 1, compare lines 19, 20 and 5; ...
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Herbal formula GAPT prevents beta amyloid deposition induced Ca2+/Calmodulin dependent protein kinase II and Ca2+/Calmodulin dependent protein phosphatase 2B imbalance in APPV717I mice
... protein kinase II (CaMKII) and Ca 2+ /Calmodulin-dependent protein phosphatase 2B (calcineurin, CaN) have been found to play important roles in memory processes and neuronal degeneration ...protein ...
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The Role of Ca2+/Calmodulin Dependent Protein Kinase II Alpha in Group 1 Metabotropic Glutamate Receptor Endocytosis and Signalling
... CaMKII is also regulated by endogenous proteins, which negatively regulate its activity. CaM-KIIN is a naturally expressed CaMKII inhibitor found in the brain. It binds to the catalytic site of activated or ...
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Requirement for Ca2+/calmodulin–dependent kinase II in the transition from pressure overload–induced cardiac hypertrophy to heart failure in mice
... Ca 2+ /calmodulin–dependent kinase II (CaMKII) has been implicated in cardiac hypertrophy and heart failure. We generated mice in which the predominant cardiac isoform, CaMKIIδ, was genetically ...
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Ca2+/calmodulin dependent kinase II triggers cell membrane injury by inducing complement factor B gene expression in the mouse heart
... Here, we provide new evidence that a cardiomyocytes express the inflammatory gene Cfb and that Cfb expression increases with pathological stress, while lack of Cfb improves the response [r] ...
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Ca2+ regulatory proteins in cardiomyocytes from the right ventricle in children with congenital heart disease
... Abbreviations ANOVA: one-way analysis of variance; BLAST: Basic Local Alignment Search Tool; CaMKII: Ca2+/calmodulin-dependent protein kinase II; CASQ: Calsequestrin; CHD: Congenital Hea[r] ...
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Molecular basis for the modulation of native T type Ca2+ channels in vivo by Ca2+ /calmodulin dependent protein kinase II
... the kinase mediated the phosphorylation of Ser1198 in the II-III loop and the positive feedback regulation of channel gating both in intact cells in situ and in cells of the native adrenal zona glomerulosa ...
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Tong Luo Jiu Nao ameliorates Aβ1–40 induced cognitive impairment on adaptive behavior learning by modulating ERK/CaMKII/CREB signaling in the hippocampus
... protein kinase (MAPK) family and necessary for cell growth, differentiation, survival, molecular information processing and structural changes stabilizing in dendritic spines ...conserved kinase cascade ...
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Calcium and mitosis entry in the early sea urchin embryo
... CaM kinase II releases the egg from metaphase arrest at fertilisation (Lorca et ...with calmodulin degradation (Singh and Chatterjee, 1988; Uno ...
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CAMKII as a therapeutic target for growth factor–induced retinal and choroidal neovascularization
... revealed a role for this kinase in modulating ion homeostasis, nitric oxide production, and agonist‑in‑ duced changes in vascular permeability (17). We have previously reported that CAMKII acts as a key signaling ...
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AMP activated protein kinase regulates CO2 induced alveolar epithelial dysfunction in rats and human cells by promoting Na,K ATPase endocytosis
... Immunohistochemistry. Longitudinal sections from fixed lungs were embedded in paraffin for immunohistochemical analysis. Primary anti- body directed against the HA epitope (1:500 dilution) was added for 1 h at room ...
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Dichotomy of Ca2+ in the heart: contraction versus intracellular signaling
... tion of HDAC5 nuclear export through CaMKII in adult ventricular cardiomyo- cytes (2). HDAC4/5 activity and nuclear occupancy are directly regulated by CaMK-, PKC-, and protein kinase D–mediated (PKD-mediated) ...
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On the Ca2 + binding and conformational change in EF hand domains: Experimental evidence of Ca2 + saturated intermediates of N domain of calmodulin
... [63] A. Houdusse, J.F. Gaucher, E. Krementsova, S. Mui, K.M. Trybus, C. Cohen, Crystal structure of apo-calmodulin bound to the first two IQ motifs of myosin V reveals essential recognition features, Proc Natl ...
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Regulation of Metabotropic Glutamate Receptor 5 activity by Ca2+/Calmodulin-dependent Protein Kinase IIα
... Human embryonic kidney (HEK293) cells were obtained from American Type Culture Collection (Manassas, VA, USA). Fetal Bovine Serum (FBS), minimum essential medium (MEM), Dulbecco’s Modified Eagle Medium (DMEM), 0.25% ...
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The role of tau in neurodegeneration
... AD: Alzheimer's disease; APP: amyloid precursor protein; CaMKII: calcium- and calmodulin-dependent protein kinase II; Cdk5: cyclin-dependent kinase-5; FTDP-17: frontal temporal dementia [r] ...
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Evidence for High Affinity Ca2+ ATPase Activity and ATP Driven Ca2+ Transport in Membrane Preparations of the Gill Epithelium of the Cichlid Fish Oreochromis Mossambicus
... Presence of calmodulin In our reports on eel gill plasma membranes we concluded that the high-affinity Ca2+-ATPase in these membranes is calmodulin-dependent and that the membrane fracti[r] ...
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