Ca2+ oscillations
Ca2+ oscillations in the activation of the egg and development of the embryo in mammals
... Int J De, Biol ~2 1 10(19981 Rrllino Ca2+ oscillations in the activation of the egg and development of the embryo in mammals KEITH T JONES Department of Anatomy and Developmental Biofogy, University C[.] ...
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Sperm triggered [Ca2+] oscillations and Ca2+ homeostasis in the mouse egg have an absolute requirement for mitochondrial ATP production
... Simultaneous imaging of mitochondrial redox state NADH and flavoprotein autofluorescence and [Ca2+]i revealed that sperm-triggered [Ca2+] oscillations are transmitted to the mitochondria[r] ...
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Endothelin action in rat liver Receptors, free Ca2+ oscillations, and activation of glycogenolysis
... High affinity binding sites for endothelin (ET) were identified on rat liver plasma membranes. Binding of 125I-ET-1 with its site was specific, saturable, and time dependent (kobs = 0.019 +/- 0.001 min-1), but ...
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Sequential forward and reverse transport of the Na+ Ca2+ exchanger generates Ca2+ oscillations within mitochondria
... NCLX rescues matrix Ca 2+ signals in depolarised mitochon- dria. Ca 2+ flux through MCU is steeply dependent on the voltage gradient across the inner mitochondrial membrane 6 and MCU open probability decreases as the ...
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Regulation of agonist induced Ca2+ oscillations by intraluminal Ca2+ : an experimental and theoretical study
... Ca 2+ ] pro- duced when Ca 2+ release is triggered are below the resolution of the microscope used in both time and spatial dimensions. The experiments were conducted at 1 pixel = 0.167 µm and 25 frames per second. Thus ...
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PLCζ is the physiological trigger of the Ca2+ oscillations that induce embryogenesis in mammals but conception can occur in its absence
... and probably in eggs of all mammals. Remarkably, a few eggs fertilized by Plcz1 – sperm can develop to the blastocyst stage in vitro , and natural mating of Plcz1 –/– males with wild-type females also results in low ...
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Airway smooth muscle relaxation results from a reduction in the frequency of Ca2+ oscillations induced by a cAMP-mediated inhibition of the IP3 receptor
... Relaxation of airways by repeated exposure to ISO Although we found that ISO induced a concentration- dependant relaxation of pre-contracted airway, this relax- ation response did not pe[r] ...
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Mitochondrial respiration and Ca2+ waves are linked during fertilization and meiosis completion
... Indeed after meiotic Ca2+ oscillations have occurred, FCCP perfusion induced a Ca2+ transient in the vegetal region of the egg superimposed on the slow and sustained increase in [Ca2+]c [r] ...
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ASPECTS OF THE AMLODIPINE PLEIOTROPY IN BIOCHEMISTRY, PHARMACOLOGY AND CLINICS
... Although amlodipine alone caused Ca2+ release from thapsigargin-sensitive Ca2+ stores, such an effect was not reproduced by other dihydropyridine Ca2+ channel blockers, including nicardi[r] ...
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Roles of Ca2+ and Na+ on the modulation of antidiuretic hormone action on urea permeability in toad urinary bladder
... of Ca2+ and Na+ in the stimulation-permeability coupling sequences by which antidiuretic hormone (ADH) induces a cyclic AMP (cAMP)-mediated increase in urea permeability in toad urinary ...or Ca2+ or ...
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Subcellular calcium dynamics in a whole cell model of an atrial myocyte
... However, increasing the Ca2+ release flux compensated for the lack of peripheral Ca2+ release site activation, and promoted centripetal Ca2+ waves Fig.. Similarly, decreasing the thresho[r] ...
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Effects of sea water and stanniectomy on branchial Ca(2+) handling and drinking rate in eel (Anguilla anguilla L )
... Effects of stanniectomy on ATP- and Na+-dependent Ca2+ transport The kinetics of the Ca2+-ATPase and Na+/Ca2+-exchanger in basolateral plasma membrane vesicles of the gills of freshwater[r] ...
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On the Ca2 + binding and conformational change in EF hand domains: Experimental evidence of Ca2 + saturated intermediates of N domain of calmodulin
... crystal contact with another QLKI+Ca 2+ molecule where both molecules face each other with their hydrophobic surface which is well known to interact with protein targets of calmodulin (Fig. S1). Interestingly, this ...
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Chain reaction Ca2+ signaling in the heart
... On a beat-to-beat basis, Ca 2+ entry through voltage-gated Ca 2+ Nonstandard abbreviations used: [Ca2+]i, cytosolic Ca2+ concentration; [Ca2+]SR, SR Ca2+ concentration; CASQ2, calsequest[r] ...
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Calcium mobilization via intracellular ion channels, store organization and mitochondria in smooth muscle
... 11 Calcium Mobilization via Intracellular Ion Channels, Store Organization… 245 raded Ca2+ Release, Ca2+ Waves and Local Ca2+ Events G from a Luminally-Continuous Store If the Ca2+ sto[r] ...
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Cardioprotection Via Modulation of Calcium Homeostasis by Thiopental in Hypoxia Reoxygenated Neonatal Rat Cardiomyocytes
... The Ca2+ entry across the membrane through L-type Ca2+ channels is balanced by the efflux of Ca2+ from the cell via the NCX and PMCA1.36 In the present results, the density of L-type Ca2[r] ...
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Na+/Ca2+ exchange current in ventricular myocytes of fish heart: contribution to sarcolemmal Ca2+ influx
... ∫ICa µmol l−1, integrated Ca2+ influx through L-type Ca2+ channels; ∫IEx µmol l−1, integrated Ca2+ influx through reverse Na+/Ca2+ exchange; ∫Iit, integrated Ca2+ efflux through forward [r] ...
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Role of the Ca(2+) sensing receptor in divalent mineral ion homeostasis
... Model for the role of the extracellular Ca2+ Ca2+o-sensing receptor CaSR in regulating NaCl and Ca2+ Mg2+ reabsorption in the kidney thick ascending limb TAL.. Ca2+mediated activation of[r] ...
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Changes of SERCA activity have only modest effects on sarcoplasmic reticulum Ca2+ content in rat ventricular myocytes
... Mean data for the effects of changes of SERCA activity on the amplitude of the systolic Ca2+ transient and SR Ca2+ content Data were calculated by measuring kSERCA , peak Ca2+ and SR Ca2[r] ...
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Oscillating activity of a Ca(2+) sensitive K+ channel A prerequisite for migration of transformed Madin Darby canine kidney focus cells
... Migration plays an important role in the formation of tumor metastases. Nonetheless, little is known about electrophysiological phenomena accompanying or underlying migration. Previously, we had shown that in migrating ...
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