calcium/calmodulin-dependent kinase
Calcium/calmodulin-dependent kinase IV contributes to translation-dependent early synaptic potentiation in the anterior cingulate cortex of adult mice
... Calcium/calmodulin-dependent kinase IV (CaMKIV) phosphorylates the major transcription factor, cyclic AMP- responsive element binding protein (CREB), which plays key roles in synaptic ...
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Calcium/calmodulin-dependent kinase II and Alzheimer’s disease
... It has been established that CaMKII is dysregulated in AD hippocampus (Fig. 1). We suggest that this dysregu- lation is a key contributor to synaptic degeneration, NFT formation and memory deficits. However, the nature ...
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Calcium/calmodulin dependent protein kinase II links ER stress with Fas and mitochondrial apoptosis pathways
... macrophages is dependent on CaMKII. (A) Macrophages were incu- bated under control or cholesterol-loading conditions for 12 or 16 hours in the absence or presence of 10 μM KN93 or KN92 after 1 hour pre- treatment. ...
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Calcium signaling around Mitochondria Associated Membranes (MAMs)
... through calmodulin (CaM); other modulators include phosphorylation by Ca 2+ /CaM-dependent kinase II (CaMKII), cGMP-depen- dent protein kinase (PKG), protein kinase C (PKC), and ...
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Calcium/calmodulin dependent protein kinase II activity regulates the proliferative potential of growth plate chondrocytes
... How Pthrp signaling regulates CamkII function has only been partially elucidated. Our finding that calyculin A treatment globally upregulates pCamkII in chondrocytes, even in the presence of Pthrp signaling, supports a ...
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Characterization of a Toxoplasma gondii calcium calmodulin dependent protein kinase homolog
... Background: Toxoplasma gondii is an obligate intracellular parasite of the phylum Apicomplexa and a major pathogen of animals and immunocompromised humans, in whom it causes encephalitis. Understanding the mechanism of ...
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Advances of exosome in the development of ovarian cancer and its diagnostic and therapeutic prospect
... 78 In gastric cancer, exosomes from mesenchymal stem cells could activate calcium/calmodulin-dependent protein kinases (CaM-Ks) and Raf/MEK/ERK kinase cascade and increase t[r] ...
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A protein phosphatase 2A deficit in the hippocampal CA1 area impairs memory extinction
... serine/threonine phosphatases: phosphoprotein phospha- tases (PPPs), metal-dependent protein phosphatases, and aspartate-based phosphatases [1]. Protein phosphatase 1 (PP1), 2A (PP2A), and 2B (PP2B) are belong to ...
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The calcium/calmodulin regulated kinase cascade in learning and memory
... M APK, and the Ca^VCaM regulated kinases, and extensive cross talk has been described between these signalling cascades. O f the CaMKs, CaMKIV has emerged as the m ost im portant kinase m ediating activity ...
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Toward transcriptional therapies for the failing heart: chemical screens to modulate genes
... cyclin-dependent kinase 9 signaling was recently shown to be associ- ated with repression of MEF2-mediated PGC-1 expression ...axis Kinase cascades can certainly regulate cardiac gene expression ...
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Gene Expression Profile of Calcium/Calmodulin-Dependent Protein Kinase IIα in the Rat Hippocampus during Morphine Withdrawal
... protein kinase with its α and β isoforms highly expressed in the central nervous system and enriched at synaptic structures especially in the hippocampus (Chen et ...
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Journal of Applied Pharmaceutical Science
... that calcium mediated secondary messengers play a crucial role in the mechanism of addictive process and oxidative stress induced by chronic opioid ...usage. Calcium/calmodulin-dependent ...
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22697eb81f398b7abee832a39a01daec442f602b.pdf
... to calcium/calmodulin connects two principal mecha- nisms in signaling processes: protein phosphoryla- tion and responses to dose- and time-dependent calcium ...the ...
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Neocortical long-term potentiation and experience-dependent synaptic plasticity require alpha-calcium/calmodulin-dependent protein kinase II autophosphorylation
... barrel because this was the most direct pathway that could be involved in the in vivo plasticity, although not the only one (Fox, 2002). Second, we used current source density analysis to mea- sure changes in ...
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Calcium/Calmodulin-Dependent Protein Kinase II Regulates Caenorhabditis elegans Locomotion in Concert With a Go/Gq Signaling Network
... Our quantitative analysis of the unc-43 ( gf ) single mutants, rather than like unc-43 ( null ): the double suppression is consistent with this model since our data mutants are about as [r] ...
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Plasmodium falciparum Calcium Dependent Protein Kinase 2 Is Critical for Male Gametocyte Exflagellation but Not Essential for Asexual Proliferation
... FIG 1 PfCDPK2 is expressed in the asexual stages of P. falciparum. (A) Domain organization of PfCDPK2. The figure represents the N-terminal kinase domain, the calmodulin-like domain (CAM-LD), and the ...
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Reduced Activity of Mutant Calcium Dependent Protein Kinase 1 Is Compensated in Plasmodium falciparum through the Action of Protein Kinase G
... protein kinase with one with a different side ...bumped kinase inhibitors ...falciparum calcium-dependent protein kinase 1 ...protein kinase G ...another kinase under the ...
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CAMKII as a therapeutic target for growth factor–induced retinal and choroidal neovascularization
... Phospho-kinase arrays. Phospho‑antibody array analysis was carried out using the Proteome Pro‑ filer Human Phospho‑Kinase Array (R&D Systems) according to the manufacturer’s instructions. HRMECs were ...
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Expression of constitutively active erythropoietin receptor in pyramidal neurons of cortex and hippocampus boosts higher cognitive functions in mice
... days, dependent on indivi- dual performance, and with a daily session duration of 30 minutes) where mice were taught to associate nose pok- ing into an illuminated hole with reward (phase S1), and then trained to ...
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p600 stabilizes microtubules to prevent the aggregation of CaMKIIα during photoconductive stimulation
... a proxy of neuronal death, via direct binding to calmodulin in a microtubule- independent manner. Using photoconductive stimulation coupled with live imaging of single neurons, we identified a distinct mechanism ...
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