calmodulin-dependent protein kinase
The Role of Ca2+/Calmodulin Dependent Protein Kinase II Alpha in Group 1 Metabotropic Glutamate Receptor Endocytosis and Signalling
... Adult CD-1 mice were from Charles River (Wilmington, MA). Human Embryonic Kidney (HEK293) Cells were from American Type Culture Collection (Manassas, VA). Cell culture reagents were from Invitrogen (Burlington, ON): ...
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Investigating and characterizing the binding activity of the immobilized calmodulin to calmodulin-dependent protein kinase I binding domain with atomic force microscopy
... a protein pattern in which protein film was made only partially covered the MUTMS disk ...and protein. To create protein molecules partially covered patterns, we swabbed the surface with a ...
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Regulation of Metabotropic Glutamate Receptor 5 activity by Ca2+/Calmodulin-dependent Protein Kinase IIα
... G protein-coupled receptors (GPCRs) make up the largest family of transmembrane receptors that function to transduce extracellular signals into intracellular responses (Lagerstrom and Schioth, ...binding ...
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Characterization of a Toxoplasma gondii calcium calmodulin dependent protein kinase homolog
... putative protein (3,197 amino acids) was too large to be expressed in ...TgCaMKrk kinase domain (N-terminal 866 amino acids), which includes the cata- lytic domain, as a glutathione S-transferase (GST) ...
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Herbal formula GAPT prevents beta amyloid deposition induced Ca2+/Calmodulin dependent protein kinase II and Ca2+/Calmodulin dependent protein phosphatase 2B imbalance in APPV717I mice
... (CaM)-dependent protein kinase II (CaMKII) and Ca 2+ /Calmodulin-dependent protein phosphatase 2B (calcineurin, CaN) have been found to play important roles in memory processes ...
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Ca2+/calmodulin dependent protein kinase II regulates cardiac Na+ channels
... In heart failure (HF), Ca 2+ /calmodulin kinase II (CaMKII) expression is increased. Altered Na + channel gating is linked to and may promote ventricular tachyarrhythmias (VTs) in HF. Calmodulin ...
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A protein phosphatase 2A deficit in the hippocampal CA1 area impairs memory extinction
... metal-dependent protein phosphatases, and aspartate-based phosphatases [1]. Protein phosphatase 1 (PP1), 2A (PP2A), and 2B (PP2B) are belong to PPPs, and numerous studies have established that they ...
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Journal of Applied Pharmaceutical Science
... Calcium/calmodulin-dependent protein kinase II (CaMKII), is a major calcium regulated signal transducer that controls many neuronal systems and play important role in neuronal plasticity and ...
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Endothelial nitric oxide synthase: a potential therapeutic target for cerebrovascular diseases
... /calmodulin-dependent protein kinase kinase- β ; Cav-1: caveolin-1; CBF: cerebral blood flow; cGMP: cyclic guanosine monophosphate; DCI: delayed cerebral ischemia; eNOS: endothelial ...
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Tong Luo Jiu Nao ameliorates Aβ1–40 induced cognitive impairment on adaptive behavior learning by modulating ERK/CaMKII/CREB signaling in the hippocampus
... surface protein receptors and intracellular signal transductions, including acetylcholine (Ach), glutamate (Glu), muscarinic acetylcho- line receptors (mAChR), N-methyl-D-aspartic acid (NMDA) receptors, ...
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Diastolic spontaneous calcium release from the sarcoplasmic reticulum increases beat-to-beat variability of repolarization in canine ventricular myocytes after β-adrenergic stimulation.
... AP action potential APD action-potential duration βAR β-adrenergic receptor BVR beat-to-beat variability of repolarization duration CaMKII Ca2+/calmodulin-dependent protein kinase II CaT[r] ...
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Toward transcriptional therapies for the failing heart: chemical screens to modulate genes
... cyclin-dependent kinase 9 signaling was recently shown to be associ- ated with repression of MEF2-mediated PGC-1 expression ...axis Kinase cascades can certainly regulate cardiac gene expression ...
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Calcium/calmodulin-dependent kinase II and Alzheimer’s disease
... CaMKII is a holoenzyme of 12 subunits, each derived from one of four genes (α, β, γ and δ) [28]. In rat fore- brain, αCaMKII and βCaMKII are the most abundant subunits, with the former expressed 3–4 times more than the ...
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Calcium signaling around Mitochondria Associated Membranes (MAMs)
... through calmodulin (CaM); other modulators include phosphorylation by Ca 2+ /CaM-dependent kinase II (CaMKII), cGMP-depen- dent protein kinase (PKG), protein kinase C ...
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22697eb81f398b7abee832a39a01daec442f602b.pdf
... many protein kinases by binding to calcium/calmodulin connects two principal mecha- nisms in signaling processes: protein phosphoryla- tion and responses to dose- and time-dependent calcium ...
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AMP activated protein kinase regulates CO2 induced alveolar epithelial dysfunction in rats and human cells by promoting Na,K ATPase endocytosis
... AMP-activated protein kinase (AMPK) in AECs, a key regulator of metabolic .../calmodulin-dependent kinase kinase-b (CaMKK- ...
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Betaine promotes cell differentiation of human osteoblasts in primary culture
... To further elucidate the osteogenic effect of BET, we eval- uated ERKs activation. Western blot results showed that BET (10 mM) increased significantly the phosphorylation of ERK1 (p < 0.001) and ERK2 (p < 0.001) ...
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Abnormalities of T cell signaling in systemic lupus erythematosus
... CD44 is a T cell surface adhesion molecule that recog- nizes and binds to its ligand hyaluronic acid in tissues and thus enables T cells to migrate into peripheral tissues. Naïve T cells express low levels of CD44 ...
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Ca2+ regulatory proteins in cardiomyocytes from the right ventricle in children with congenital heart disease
... The protein expression level of SLN was evaluated by IF on paraffin sections. Slides were rinsed 3 times in phosphate- buffered saline (PBS, Invitrogen), blocked with 5% bovine serum albumin (Invitrogen) for 45 ...
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Sepsis-induced myocardial dysfunction: pathophysiology and management
... Extracellular histones function as endogenous DAMPs that might interact with TLR2 and TLR4 on various cell types, including cardiomyocytes to reduce mitochondrial membrane potential and ATP levels. These activities cause ...
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