Cancer genome
The Roche Cancer Genome Database 2.0
... For cell line queries we offer searches by cell line name or frequently used synonyms. The resulting page presents a card with general information on the sample (name, synonyms, tissue, histology, etc.) on the left-hand ...
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Age-related somatic mutations in the cancer genome
... massive cancer-sequencing efforts, such as The Cancer Genome Atlas (TCGA), have made available a wealth of data on tumor-associated somatic mutations from many individuals and tissue types ...
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Novel Methods in the Study of the Breast Cancer Genome: Towards a Better Understanding of the Disease of Breast Cancer
... for genome-wide mapping of DNA methylation information: 1) endonuclease digestion-based methods such as modified methylation specific digital karyo- typing (MMSDK) [27]; 2) affinity enrichment-based methods such ...
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Identification of differentially expressed miRNAs in early-stage cervical cancer with lymph node metastasis across The Cancer Genome Atlas datasets
... The Cancer Genome Atlas data, hsa-miR-508, hsa-miR-509-2, and hsa- miR-526b expression levels were significantly lower in early-stage CESC patients with LNM than in patients without ...estrogen ...
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Cancer genome landscape: a radiologist’s guide to cancer genome medicine with imaging correlates
... a cancer to arise ...whole genome sequencing: many driver mutations can- not be identified with current sequencing techniques, and the vast majority of cancer genome studies focused at ...
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The cancer genome atlas pan-cancer analysis project.pdf
... of genome sequenc- ing has fallen, the next Pan-Cancer enter- prise will be able to analyze large numbers of whole-genome sequences across tumor ...the genome, which have not been as well ...
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Catch my drift? Making sense of genomic intra-tumour heterogeneity.
... in cancer evolution are: How did the tumour grow in a specific patient? How did one cell become 100 billion cells? What patterns do we expect to see in the data depending on the different evolutionary trajectories ...
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Integrative analysis of gene expression profiles reveals specific signaling pathways associated with pancreatic duct adenocarcinoma
... in cancer across six GEO datasets are associated with PDAC survival, based on data in The Cancer Genome Atlas and International Cancer Genome Consortium ...
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CVE: an R package for interactive variant prioritisation in precision oncology
... precision cancer medicine is the assessment of the druggability of candidate vari- ...lung cancer’ (TALC) publication [27]; the ’trends in the exploitation of novel drug targets’ (TEND) publication [28]; ...
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ACE2 increases with age, but is not associated with sex. Asians show a similar ACE2 expression to other races. Furthermore, the frequencies of ACE2 alleles in
... expression is not affected during tumorigenesis, suggesting that the transcriptome data from the more than 1000 lung cancer samples in The Cancer Genome Atlas (TCGA) can be used to study ACE2 ...
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<p>Comprehensive analysis of genes based on chr1p/19q co-deletion reveals a robust 4-gene prognostic signature for lower grade glioma</p>
... Materials and methods: The data was downloaded from The Cancer Genome Atlas (TCGA), Chinese Glioma Genome Atlas (CGGA) and Gene Expression Omnibus (GEO). Differentially expressed genes (DEGs) between ...
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Advancing clinical oncology through genome biology and technology
... in cancer and countless more alterations whose biological and clinical significance is ...My Cancer Genome developed at the Vanderbilt-Ingram Cancer ...
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Emergency medical genomes: a breakthrough application of precision medicine
... The Cancer Genome Atlas (TCGA) of the National Can- cer Institute (NCI), the International Cancer Genome Consortium (ICGC), and the Pediatric Cancer Genome Project ...with ...
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Emerging molecular classifications and therapeutic implications for gastric cancer
... Gastric cancer (GC) is a highly aggressive and life‑threatening ...the Cancer Genome Atlas (TCGA) research network conducted a comprehensive molecular evaluation of primary GCs and proposed a new ...
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Deciphering the genomic, epigenomic and transcriptomic landscapes of pre invasive lung cancer lesions
... External validation using TCGA Lung cancer methylation datasets publically available through The Cancer Genome... Atlas TCGA were downloaded using GenomicDataCommons download tools18.[r] ...
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Pan-cancer patterns of DNA methylation
... Definition and function of DNA methylation DNA methylation usually occurs at cytosine-guanine (CpG) dinucleotides, where DNA methyltransferases (DNMTs) catalyze the transfer of a methyl group to pos- ition 5 of a ...
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Systematic characterization of germline variants from the DiscovEHR study endometrial carcinoma population
... The Cancer Genome Atlas (TCGA) illustrated that cancer suscepti- bility genes could be identified across several cancer types using data produced from the germline, including but not limited ...
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<p>Development and Validation of a Novel 8 Immune Gene Prognostic Signature Based on the Immune Expression Profile for Hepatocellular Carcinoma</p>
... The Cancer Genome Atlas; ICGC, International Cancer Genome Consortium; IPSHCC, immune prognostic signature of HCC; AUC, area under the curve; FDR, false discovery rate; HR, hazard ratio; KEGG, ...
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Immuno-stimultory/regulatory gene expression patterns in advanced ovarian cancer
... We have conducted a computational study of gene expression patterns associated with prognosis of advanced ovarian cancer patients by re-analyzing data from the Cancer Genome Atlas. Using our method ...
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Downexpression of HSD17B6 correlates with clinical prognosis and tumor immune infiltrates in hepatocellular carcinoma
... The cancer genome atlas (TCGA) had both sequenc- ing and pathological data on 30 different cancers ...(The cancer genome atlas, TCGA-LIHC) dataset, including data from 438 cases with pathology ...
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