Cancer, Medicinal Chemistry
Therapeutic importance of peptidomimetics in medicinal chemistry
... Dunehoo et al. found that RGD peptides/peptidomimetics have been marketed as anti-thrombic agents and are being investigated for inhibiting tumor angiogenesis. Other cell adhesion peptides derived from ICAM-1 and LFA-1 ...
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PYRAZOLES IN MEDICINAL CHEMISTRY
... 3. These hybrid compounds have obtained coupling of the two N-Boc deprotected CPI pyrazole analogs with three mixed pyrazole–pyrrole compounds called lexitropsins (or information-reading oligopeptides), consisting of a ...
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THIOSEMICARBAZONE COMPLEXES AS VERSATILE MEDICINAL CHEMISTRY AGENTS: A REVIEW
... [120,123,126-131].They exhibited promising properties in vivo but also caused some side effects which including diarrhea, nausea, neutropenia, thrombocytopenia, methemoglobinemia[132-133].A considerable amount of study ...
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One pot synthesis and antibacterial activity of substituted benzothiazolylacetamide
... Benzothiazole derivatives are an important class of heterocyclic compounds that exhibit a wide range of biological properties in medicinal and agricultural chemistry 1-5 . Further industrial applications as ...
7
Synthesis, Characterization and Antimicrobial Activity of Schiff Base (E) N (4 (2 Hydroxybenzylideneamino) Phenylsulfonyl) Acetamide Metal Complexes
... coordination chemistry and medicinal chemistry, for examples, cobalt(II), copper(II), nickel(II) and zinc(II) complexes of mercaptothiadiazole-derived from furanyl, thienyl, pyrrolyl, sa- licylyl and ...
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Synthesis and Invitro Anti-Cancer Evaluation of Some Novel 2, 3 Disubstituted Thiazolidinones
... Despite the optimal use of available anticancer drugs (ACDs), many patients fail to experience therapeutic efficacy and others do so only at the expense of significant toxic side effects. The limitations with the ...
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Reactive Oxygen Species and their Interaction with Platelets
... inhibitors, the compounds that increase adhesion, promote cellular interactions and trigger vessel repair. Dense granules contain serotonin, adenine nucleotide and calcium. Lysosomal enzymes contribute to the formation ...
5
Fundamentals of Medicinal Chemistry (2003) By Gareth Thomas pdf
... where r is the position of the electron. The use of the Hartree–Fock approxima- tion reduces computer time and reduces the cost without losing too much in the way of accuracy. Computer time may be further reduced by the ...
304
Studies of the Interaction of Au(I)-Phosphole Complexes with DNA and their Relation to Biological Activity
... It is well-known that Au(I) complexes are potentially attractive as anticancer agents due to their strong antiproliferative potency and inhibit the enzyme thioredoxin reductase (TrxR) with high potency and specificity. ...
7
Biotransformations in Drug Synthesis: A Green and Powerful Tool for Medicinal Chemistry
... Many other cases could be commented to illustrate the great potential for the (industrial) use of biocatalysts in drug synthesis, as covered in the increasingly number of revisions published in literature, and previously ...
7
One pot Synthesis and Antibacterial Activity of Substituted Benzothiazolyl Acetamide
... Benzothiazole derivatives are an important class of heterocyclic compounds that exhibit a wide range of biological properties in medicinal and agricultural chemistry 1-5 . Further industrial applications as ...
7
Cassia Tora: Its Chemistry, Medicinal Uses and Pharmacology
... plants. Medicinal plants still play an important role in emerging and developing countries of Asia, both in preventive and curative treatments as these are relatively safe, cost effective and efficacious solutions ...
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1, 3, 4 OXADIAZOLE IN MEDICINAL CHEMISTRY: AN OVERVIEW
... Five membered aromatic systems having three heteroatoms at symmetrical positions such as 1, 3, 4 Oxadiazole have been studied extensively owing to their interesting pharmacological activities. This review article covers ...
9
CHEMISTRY AND BIOACTIVITY OF CINNAMALDEHYDE: A NATURAL MOLECULE OF MEDICINAL IMPORTANCE
... Anticancer: Recent research reports 54 documented the anticancer activity of cinnamaldehyde/cinnamic aldehyde was observed in cell culture and animal models of the disease. Proliferation, invasion, and tumor growth were ...
8
COMPUTER-ASSISTED CLASSES ON MEDICINAL CHEMISTRY OF BARBITURATES AND THIOBARBITURATES
... or chemistry students on ADMET parameters of barbiturates and thiobarbiturates in the context of their molecular structure and gathering students’ feedback on the ...Computational Chemistry Laboratory web ...
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COMPUTER-ASSISTED CLASSES ON MEDICINAL CHEMISTRY OF NEUROLEPTICS
... on medicinal chemistry and molecular pharmacology of neuroleptics involve a few computational procedures which are performed by participating students, under supervision of a ...
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Synthesis and Anticancer Activity of Mono Carbonyl Analogues of Curcumin
... colon cancer cell line ...other cancer cell lines, including lines derived from stomach (GCIY, SH10TC), lung (LK87), breast (MCF7), ovary (OVK18), prostate (PC3), pancreas (PK9), bile duct (HuCCT1), thyroid ...
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Synthesis and Pharmacological Evaluation of Some New Entities of Bis Indole Substituted Coumarin Derivatives.
... Drug from natural origin can come from three sources. They can originate from minerals. Various simple inorganic substances are still in use in medicine: sulphur, iodine, phosphates and arsenates, calcium, sodium, ...
86
The Journal of Computer-Aided Molecular Design: a bibliometric note
... modern medicinal chemistry, protein engineering, catalytic design, polymer studies and many other facets of organic, inorganic, physical and biological chemistry” ...
10
8122415393 Medicinal Chemistry pdf
... It is, of course, an usual practice to have a chemical laboratory directly under the command and supervision of a senior cadre laboratory technical personnel who should be consulted, as and when required, for his expert ...
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