Cancer Stem-Like Cells
Oncolytic vaccinia virus GLV 1h68 strain shows enhanced replication in human breast cancer stem like cells in comparison to breast cancer cells
... GI-101A cells resulted in cell population with CD44 + CD24 + ESA + and CD44 + CD24 - ESA + markers We examined whether the treatment of GI-101A cell line with TGF-β1, similar to HMLE cell line [13,14], would lead ...
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Identification of inhibitors of ovarian cancer stem-like cells by high-throughput screening
... Ovarian cancer is the most lethal of gynecological can- cers [1] despite its typically high initial response rate to chemotherapy ...ovarian cancer stem-like cells (CSC), character- ...
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The heterogeneity of cancer stem-like cells at the invasive front
... Cancer stem-like cells (CSCs) are defined as the enhanced tumorigenic subpopulation of cancer ...transit-amplifying cells, and ...progenitor/daughter cells at various ...
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DC120, a novel AKT inhibitor, preferentially suppresses nasopharyngeal carcinoma cancer stem-like cells by downregulating Sox2
... NPC cells. In our present study, we found that DC120 targeted AKT in cancer stem-like SP cells, and the effect was correlated with the reduction of pAKT and the increased expression of ...
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Co-expression of Lgr5 and CXCR4 characterizes cancer stem-like cells of colorectal cancer
... Lgr5+/CXCR4+ cells were transplanted ...tumor cells for the next round of ...Lgr5+/CXCR4+ cells had significantly higher rates of tumor development, compared to others, based on bioluminescence ...
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An ABCG2 non-substrate anticancer agent FL118 targets drug-resistant cancer stem-like cells and overcomes treatment resistance of human pancreatic cancer
... Cancer cells treated with and without FL118 (in some ex- periments in the presence of MG132) were lysed in RIPA buffer containing 150 mM NaCl, 1.0% IGEPAL CA-630, 0.5% sodium deoxycholate, 0.1% SDS, and 50 ...
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Cyr61-positive cancer stem-like cells enhances distal metastases of pancreatic cancer
... We used a recently published model for suppressing Cyr61 expression in pancreas cancer. The AAV-shCyr61- LUC-GFP and AAV-LUC-GFP were infused into mouse pancreas via pancreatic duct as described originally [41] ...
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Flubendazole, FDA-approved anthelmintic, targets breast cancer stem-like cells
... After incubated with varying concentration of flubendazole and vehicle (DMSO) for 48 hr, cells were harvested and lysed in RIPA buffer. Protein concentration was determined by Bradford assay. Briefly, cell lysates ...
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A candidate Chinese medicine preparation Fructus Viticis Total Flavonoids inhibits stem like characteristics of lung cancer stem like cells
... follicle stem cells (HF-SCs) results in increased tumor development and malignant transformation ...of cancer stem cell-like prop- erties and EMT features in cisplatin-resistant A549 ...
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Genistein decreases the breast cancer stem-like cell population through Hedgehog pathway
... contain cancer stem cells, which possess the self-renewal capacity, chemoresistance and an enhanced tumorigenicity ...from stem cells or germ cells was first pro- posed almost ...
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Cellular prognostic markers in hepatitis-related hepatocellular carcinoma
... immune cells as well as non-hematopoietic cells have shown to correlate with HCC ...stellate cells (HSCs), cancer- associated fibroblasts (CAFs), neutrophils, cancer stem- ...
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A rational approach for cancer stem-like cell isolation and characterization using CD44 and prominin-1(CD133) as selection markers
... ovarian cancer stem-like cells (CSLC) capable of sphere formation from ascites cultures [5], whereas Zhang et ...ovarian cancer-initiating cells from primary human tumors ...
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Gene methylation of human ovarian carcinoma stromal progenitor cells promotes tumorigenesis
... mesenchymal-like cells are non-tumorigenic. However, epithelial-like cells may be tumorigenic with cancer stem-like characteristics which may enhance SKOV3-Luc tumor ...
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CD133 as a Biomarker of Thyroid Cancer Stem Cells
... thyroid cancer (ATC). It has undifferentiated tumor cells that arenot similar to the normal thyroid cells and cannot form the ...tumor cells in ATC might be due to the CD133-expressing in ...
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MiR-1207 overexpression promotes cancer stem cell–like traits in ovarian cancer by activating the Wnt/β-catenin signaling pathway
... tumor cells override the negative regulatory effects to maintain constitutive activation of Wnt/β-catenin signaling, which is commonly observed in various cancers, remains ...ovarian cancer activated ...
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To grab the stroma by the horns: From biology to cancer therapy with mesenchymal stem cells
... the cancer stem cell niche and modulate their function, at least in part via BMP, PGE2, and β-catenin signaling ...MSC-like cells (with differentiation capacity, immunophenotype, and colony ...
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Nestin suppression attenuates invasive potential of endometrial cancer cells by downregulating TGF-β signaling pathway
... a stem cell marker is expressed in several ...endometrial cancer cell lines express high to moderate levels of ...a cancer stem- like cell subpopulation expressing ...the cancer ...
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<p>Differential Expression And Effects Of Peroxiredoxin-6 On Drug Resistance And Cancer Stem Cell-Like Properties In Non-Small Cell Lung Cancer</p>
... SW620 cells were fi xed with 4% PFA for 20 min, and then incubated with ...treated cells were blocked with 5% goat serum for 30 min at 37°C, and then incubated overnight with the anti-F-actin IgG (1:2000, ...
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Quantitative proteomic analysis of sphere-forming stem-like oral cancer cells
... colorectal cancer stem cells [45] and may serve as a potential therapeutic target for pancreatic adenocarcinoma ...CSC- like UM1 ...neck cancer have been studied previ- ...DSG3-positive ...
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The role of P63 in cancer, stem cells and cancer stem cells
... rare stem-like cells called cancer stem cells (CSC) or cancer-initiating cells ...tumor cells, and the ability to withstand cancer therapy [173, ...
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