Cannabinoid receptor 2
Stimulation of cannabinoid receptor 2 (CB2) suppresses microglial activation
... the cannabinoid receptor 2 (CB 2 ), as demon- strated by the finding that THC inhibits helper T-cell acti- vation by normal, but not CB 2 knockout-derived, macrophages ...CD40 ...
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Cannabinoid receptor 2 activation reduces intestinal leukocyte recruitment and systemic inflammatory mediator release in acute experimental sepsis
... and 2-arachi- donylglycerol were observed in vitro to inhibit the produc- tion of TNFa released from LPS-treated rat microglial cells ...that 2-arachidonylgly- cerol inhibits TNFa release from LPS-treated ...
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Antagonism of cannabinoid receptor 2 pathway suppresses IL-6-induced immunoglobulin IgM secretion
... Results: We demonstrated that CB2 inverse agonists SR144528 and AM630, but not CB2 agonist HU308 or CB1 antagonist SR141716, effectively inhibited IL-6-induced secretion of soluble IgM without affecting cell ...
8
Cannabinoid receptor 2 expression in human proximal tubule cells is regulated by albumin independent of ERK1/2 signaling
... Our finding presented in this study, that blocking CB2 leads to an increase in albumin uptake, does not directly account for the albuminuria that is observed in animal and human models of diabetes [2]. One must ...
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Modulation of breast cancer cell viability by a cannabinoid receptor 2 agonist, JWH-015, is calcium dependent
... Our study characterizes the actions of the CB 2 -selective agonist JWH-015 on breast cancer cells in vitro and in vivo in a syngeneic murine model of late-stage breast cancer. Impor- tantly, our model does not ...
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Cannabinoid receptor 2 as a potential therapeutic target in rheumatoid arthritis
... Peripheral blood mononuclear cells from healthy donors were collected using Ficoll-Conray (Imuuno-Biological Laboratories, Gunma, Japan) gradient centrifugation. Positive selection of CD14 + monocytes was performed using ...
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Pharmacodynamics of cannabinoids
... psychotropic cannabinoid intake is then associated with opposite effects in the CNS followed by classical withdrawal symptoms such as impaired mood, irritability, anxiety, nausea, and craving after another dose, ...
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The synthetic cannabinoid WIN55,212-2 mesylate decreases the production of inflammatory mediators in rheumatoid arthritis synovial fibroblasts by activating CB2, TRPV1, TRPA1 and yet unidentified receptor targets
... containing 2 % fetal calf serum, which provides enough energy and growth factor input for cell maintenance but not to commence cellular proliferation (own ...
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Anti inflammatory effects of N acylethanolamines in rheumatoid arthritis synovial cells are mediated by TRPV1 and TRPA1 in a COX 2 dependent manner
... (SOD-2) (Lab Frontier, Seoul, Korea, LF-PA0021, 1:2000), poly(ADP-ribose) polymerase (PARP) and glyceraldehyde 3-phosphate dehydrogenase (GAPDH) (Cell Signaling, Leiden, Netherlands, #9542 and #2118, 1:1000). A ...
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Adolescent Exposure of JWH 018 “Spice” Produces Subtle Effects on Learning and Memory Performance in Adulthood
... potent cannabinoid CB1 receptor agonist during adolescence is capable of producing a variety of subtle changes affecting spatial learning and memory performance in adulthood, well after the drug exposure ...
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Cannabinoid CB1 Transmission in the Mesolimbic Reward Pathway
... major cannabinoid receptors (CBRs) are CB1 and CB2 cannabinoid receptor (CB1R and CB2R ...are 2-arachidonoylglycerol (2- AG) and anandamide, that have been shown to function as ...
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Combining rimonabant and fentanyl in a single entity: preparation and pharmacological results
... Male imprinting control region mice weighing 25–30 g were used. Spontaneous behavior was always observed in the cage before treatment and/or performance of the different tests. Animals showing spontaneous behavioral ...
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Optimization of the metabolic stability of a fluorinated cannabinoid receptor subtype 2 (CB2) ligand designed for PET studies
... investigated for the conversion of the alcohols 23c and 24c to the corresponding fluoroalkanes 23a and 24a. However, all attempts failed to give the fluoroalkanes 23a and 24a. It is assumed that the amine-moiety is ...
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Interaction between Antagonist of Cannabinoid Receptor and Antagonist of Adrenergic Receptor on Anxiety in Male Rat
... Functional interactions between cannabinoids and central noradrenergic systems have been well described (Carvalho et al., 2010a, 2010b; Gobbi et al., 2005; Mendiguren & Pineda, 2006; Muntoni et al., 2006; Oropeza et ...
7
Regulation of Adipose Tissue Metabolism by the Endocannabinoid System
... b3-adrenergic receptor agonism [7] not only stimulates BAT but also leads to browning of WAT either by transdifferentiation of existing white adipocytes or by stimulation of precursor cells to differentiate into ...
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Cannabinoid Receptor Type I Modulates Alcohol-Induced Liver Fibrosis
... of 2-AG and AEA are increased in liver dis- ease ...that 2-AG and THC induce CB1 mRNA, which is further enhanced by their combination with AA, jointly favoring the progression of fibrosis in ...and ...
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HINT1 protein cooperates with cannabinoid 1 receptor to negatively regulate glutamate NMDA receptor activity
... the receptor environment ...[41,42]. Cannabinoid receptors are distributed throughout the central nervous system [43] and the CNR1 is present at high densities in presynaptic terminals [44], as well as in ...
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nanoPaint: dynamic imaging of nanoscopic structural plasticity of the plasma membrane
... CB1 receptor in cultured hippocampal ...CB1 receptor. As observed in Figure S3a, the endogenous receptor is highly enriched in axons although it is also ubiquitously present in the plasma membrane of ...
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Increased placental expression of cannabinoid receptor 1 in preeclampsia: an observational study
... Immunohistochemical staining was performed on 16 placental samples from each study group. Anti-CB1 (GTX100219) and anti-CB2 (GTX101357) rabbit poly- clonal antibodies were obtained from GeneTex (Irvine, CA, USA), whereas ...
8
Cannabinoid CB1 receptor overactivity contributes to the pathogenesis of idiopathic pulmonary fibrosis
... Fibrosis is a highly prevalent, multifactorial, and progressive pathogenic process affecting many organs, including the lungs (1). Pulmonary fibrosis (PF) is a life-threatening disease that may benefit from simul- ...
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