Cap-independent translation
THE WARBURG EFFECT: A POSSIBLE ROLE OF CAP INDEPENDENT TRANSLATION Ajaz Ahmad Waza*, Shabir Ahmad Bhat, Sajad AliDOWNLOAD/VIEW
... protein translation in normal and stress conditions. A) Cap dependent translation: Eukaryotic initiation factor binds to the 5’- cap on the mRNA, followed by recruitment of 40S subunit to the ...
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The 5′ Untranslated Region of the Human T-Cell Lymphotropic Virus Type 1 mRNA Enables Cap-Independent Translation Initiation
... part of the Gag protein open reading frame (16, 17). Once the existence of an IRES is confirmed within the full-length 5=UTR, some studies conduct 5= and 3= truncations to map the minimal region required for IRES ...
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Cap-Independent Translation Conferred by the 5′ Leader of Tobacco Etch Virus Is Eukaryotic Initiation Factor 4G Dependent
... efficient translation from the naturally uncapped viral ...confer cap-independent translation in vivo even when present in the intercistronic region of a discistronic mRNA, indicating that the ...
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Cap-Independent Translation Mechanism of Red Clover Necrotic Mosaic Virus RNA2 Differs from That of RNA1 and Is Linked to RNA Replication
... no cap structure at the 5 ⴕ end and no poly(A) tail at the 3 ⴕ ...for cap-independent ...a cap-independent translational mechanism of RNA2 using a firefly luciferase (Luc) gene ...
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A Primary Determinant of Cap-Independent Translation Is Located in the 3′-Proximal Region of the Tomato Bushy Stunt Virus Genome
... in cap- independent translation observed in vivo was therefore not reproducible in vitro under the conditions ...detect cap-independent differ- ences in vitro differs from results ...
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Identification and Characterization of the Functional Elements within the Tobacco Etch Virus 5′ Leader Required for Cap-Independent Translation
... vivo translation of reporter mRNAs in a cap-independent manner (3, ...leader independent of any potential host factor ...conferring cap-independent translation, a series ...
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The 3′ Untranslated Region of Pea Enation Mosaic Virus Contains Two T-Shaped, Ribosome-Binding, Cap-Independent Translation Enhancers
... proximal, cap-independent translation enhancers (3=CITEs) that bind to ribosomal subunits or translation factors thought to assist in ribosome ...eukaryotic translation initiation ...
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trans Regulation of Cap-Independent Translation by a Viral Subgenomic RNA
... on cap-independent translation in the presence of sgRNA2, we engineered GfLUC so that the 5 ⬘ -proximal stem-loop of its 5 ⬘ UTR (SL-A) was able to kiss (base pair to) the BTE, and the natural ...
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Ribosome Binding to a 5′ Translational Enhancer Is Altered in the Presence of the 3′ Untranslated Region in Cap-Independent Translation of Turnip Crinkle Virus
... While these results suggest that the polypyrimidine se- quences in the 5 ⬘ TE have IRES-like properties, other results suggest that ribosome entry is more complex. In vitro toeprint- ing of bound 40S subunits suggests ...
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Mechanism of cap independent translation by long distance kissing stem loop interactions in plant viral RNAs
... vitro translation product of sgRNA2-FLAG was spiked in an extract of uninfected cells prepared by the same method that was used for attempted detection of P6-FLAG from electroporated ...
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A single nucleotide substitution in the internal ribosome entry site of foot-and-mouth disease virus leads to enhanced cap-independent translation in vivo.
... Ribavirin cures cells of a persistent Downloaded from http://jvi.asm.org/ on November 9, 2019 by guest DISCUSSION In this report, we have shown that a point mutation in the IRES element [r] ...
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Cap-independent translation by the 5' untranslated region of Theiler's murine encephalomyelitis virus.
... Comparison of the Cat and Luc activities expressed by the various bicistronic mRNAs both in transfected cells and in in vitro translation reactions strongly suggests that the TMEV 5'UTR [r] ...
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Structure and function of a novel cap independent translation element in the 3' untranslated region of a viral RNA
... Because the mRNAs of BYDV gRNA, sgRNAl and sgRNA2 all contain the same 3'terminal sequence, they use a common translation element that allows expression of their mRNAs equivalent to that[r] ...
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trans complementation of cap-independent translation directed by poliovirus 5' noncoding region deletion mutants: evidence for RNA-RNA interactions.
... Thus, neither the expression of PV 2A in the absence of the PV 5' NCR nor the inhibition of cap-dependent translation by the FMDV L protein appeared to be sufficient to produce the enhan[r] ...
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Low efficiency of the 5' nontranslated region of hepatitis A virus RNA in directing cap-independent translation in permissive monkey kidney cells.
... LEMONI* Department of Medicine, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599-7030,' and Department of Cell Research and Immunology, Tel Aviv Univers[r] ...
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Dengue Virus Utilizes a Novel Strategy for Translation Initiation When Cap-Dependent Translation Is Inhibited
... DEN translation on eIF4E may correlate with the ability of DEN to translate under conditions in which cellular translation is limited, for example, in differentiated cells such as myeloid and dendritic ...
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A Small Yeast RNA Blocks Hepatitis C Virus Internal Ribosome Entry Site (HCV IRES)-Mediated Translation and Inhibits Replication of a Chimeric Poliovirus under Translational Control of the HCV IRES Element
... IRES-mediated translation is blocked in vivo and in vitro by a small yeast RNA which was initially characterized as a specific inhibitor of PV IRES-me- diated, cap-independent translation ...
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A Viral Noncoding RNA Generated by cis-Element-Mediated Protection against 5′→3′ RNA Decay Represses both Cap-Independent and Cap-Dependent Translation
... both cap-independent and cap-poly(A)-de- pendent translation in vitro and in ...both cap-independent translation (14, 27) and neg- ative-strand RNA synthesis ...of ...
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A Ribosome-Binding, 3′ Translational Enhancer Has a T-Shaped Structure and Engages in a Long-Distance RNA-RNA Interaction
... in cap-independent translation to reduce the sizes of their genomes by forgoing mechanisms requiring ex- tensive 5= UTR sequences to attract ...particular translation initiation fac- tors, ...
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Sequence and structural elements that contribute to efficient encephalomyocarditis virus RNA translation.
... Cap-independent translation of encephalomyocarditis virus RNA: structural elements of the internal ribosomal entry site and involvement of a cellular 57-kD RNA-binding protein.. Initiati[r] ...
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