carbamoyl-P
Synthesis, biological activity evaluation and QSAR studies of novel 3 (aminooxalyl amino) and 3 (carbamoyl propionylamino) 2 phenylamino benzoic acid derivatives
... aminooxalil-, carbamoyl- and phenylamino- moieties substituted derivatives and respective methyl esters were carried out for anti- inflammatory activity employing the carrageenan-induced rat paw edema ...
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Urea synthesis in the African lungfish Protopterus dolloi hepatic carbamoyl phosphate synthetase III and glutamine synthetase are upregulated by 6 days of aerial exposure
... possesses carbamoyl phosphate III (CPS III) in the liver and not carbamoyl phosphate I (CPS I), as in the mouse Mus musculus or as in other African lungfish reported ...
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Induction of carbamoyl phosphate synthetase III and glutamine synthetase mRNA during confinement stress in gulf toadfish (Opsanus beta)
... CPSase I in amphibians and mammals does not require glutamine as its substrate, but instead feeds ammonia nitrogen directly into carbamoyl phosphate and urea synthesis (for a review, see Anderson, 1995b). In these ...
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Case Report Two novel mutations in the CPS1 gene of a newborn with carbamoyl phosphate synthetase 1 deficiency identified by next-generation sequencing
... Carbamoyl phosphate synthetase 1 (CPS1), which catalyzes the first step of the urea cycle, is a mitochondrial matrix enzyme and it is expressed in the hepatocytes and epithelial cells of the intestinal mucosa. The ...
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Isoaspartate, Carbamoyl phosphate synthase 1, and carbonic anhydrase III as biomarkers of liver injury
... mice. Carbamoyl phosphate synthase-1 (CPS-1) was partially purified and identified as the ~160 kDa protein target of PIMT in ethanol-fed rats and in PIMT KO ...
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Carbamoyl phosphate synthetase 1 deficiency: First report of this rare metabolic disorder in Kingdom of Bahrain with novel mutation
... first carbamoyl phosphate synthetase 1 (CPS1) deficiency case, confirmed genetically, in Bahrain illustrating that CPS1 deficiency is panethnic and potentially ...
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Effects of crowding on ornithine–urea cycle enzyme mRNA expression and activity in gulf toadfish (Opsanus beta)
... The gulf toadfish ( Opsanus beta ) is a facultatively ureotelic fish that excretes primarily urea under conditions of crowding or confinement. To examine the relationship between ammonia production, urea production and ...
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New developments in the treatment of hyperammonemia: emerging use of carglumic acid
... Abstract: Hyperammonemia is a true neonatal emergency with high toxicity for the central nervous system and developmental delay. The causes of neonatal hyperammonemia are genetic defects of urea cycle enzymes, organic ...
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Developmental Outcomes With Early Orthotopic Liver Transplantation for Infants With Neonatal-Onset Urea Cycle Defects and a Female Patient With Late-Onset Ornithine Transcarbamylase Deficiency
... with carbamoyl phosphate synthase deficiency, all of whom had neonatal presenta- tions and underwent orthotopic liver transplantation be- fore 1 year of age, and 1 female patient with partial X-linked ornithine ...
6
Urea cycle disorders in India: clinical course, biochemical and genetic investigations, and prenatal testing
... ARG: Arginase; ASL: Argininosuccinate Lyase; ASS1: Argininosuccinate Synthetase 1; CPS1: Carbamoyl phosphate synthetase 1; GCMS: Gas chromatography mass spectrometry; HPLC: High performa[r] ...
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Deoxycytidine production by a metabolically engineered Escherichia coli strain
... dCyd production. Using HLC007, the repressor genes, purR, pepA and argR were deleted sequentially by the same deletion method, resulting in HLC010 (Additional file 1: Figure S2C). We hypothesized that CarAB activ- ity in ...
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IN SILICO FINDING OF THE PUTATIVE DRUG TARGETS FROM HYPOTHETICAL SET OF PROTEINS FOR MYCOBACTERIUM LEPRAE TN
... ATPase activity, coupled to movement of substances Oxidoreductase activity, acting on the aldehyde or oxo group of donors Thiolester hydrolase activity Carbamoyl-phosphate synthase activ[r] ...
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Preparation of b and g lactams from carbamoyl radicals derived from oxime oxalate amides
... 2-Substituted-thiazolidine-4-carboxylic acid methyl ester amides of benzaldehyde oxalyl oxime were also prepared. It was shown by EPR spectroscopy that they also dissociated to pro- duce carbamoyl and iminyl ...
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Mutation detection in X-linked disorders: Ornithine carbamoyl transferase deficiency and Pelizaeus-Merzbacher disease
... approaches were used: single strand conformation polymorphism (SSCP) analysis and.. cytosine-guanine dinucleotide (CpG) site analysis.[r] ...
243
Potential role of N-carbamoyl glutamate in biosynthesis of arginine and its significance in production of ruminant animals
... In our current study, supplementation of 20 g/d NCG to high yielding dairy cows significantly decreased the urea N excretion in milk, plasma and urine, while the N utilization tended to [r] ...
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Nanoliposomes for Safe and Efficient Therapeutic mRNA Delivery: A Step Toward Nanotheranostics in Inflammatory and Cardiovascular Diseases as well as Cancer
... Unless otherwise specified, the data is represented as means with standard derivations (SD). All analysis for the two groups were performed using Student t-tests. All analyses containing more than two groups were ...
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Effects of ferrous carbamoyl glycine on iron state and absorption in an iron-deficient rat model
... One of such compound is iron carbamoyl glycine che- late (Fe-CGly), which has greater absorbability than other Fe sources (Wu et al. 2013; Wan et al. 2015). With the attendant benefits of increased absorption ...
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4′ Acetyl 3′′ carbamoyl [1,1′:3′,1′′ terphenyl] 2 carboxylic acid
... The carbamoyl and carboxyl groups are disor- dered with a refined occupancy ratio of ...and carbamoyl groups in a bidentate manner, and antiparallel helices are formed which extend along the b-axis ...
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tert Butyl 3 carbamoyl 4 methoxyimino 3 methylpiperidine 1 carboxylate
... Data collection: SMART Bruker, 1998; cell refinement: SAINT Bruker, 1999; data reduction: SAINT; programs used to solve structure: SHELXS97 Sheldrick, 2008; programs used to refine struc[r] ...
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Complexes containing cationic and anionic pH-sensitive liposomes: comparative study of factors influencing plasmid DNA gene delivery to tumors
... Before complexation with pDNA, the DC-Chol/DOPE liposomes had a particle size of 120–140 nm. However, the size of DC-Chol/DOPE liposomes/pDNA complexes became much larger than that of the liposomes from which they were ...
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