Carbopol 974p

Top PDF Carbopol 974p:

 FORMULATION DEVELOPMENT AND EVALUATION OF BIO-ADHESIVE CARBOPOL 974P NF POLYMER MATRIX BASED SUSTAINED RELEASE GLICLAZIDE TABLET

 FORMULATION DEVELOPMENT AND EVALUATION OF BIO-ADHESIVE CARBOPOL 974P NF POLYMER MATRIX BASED SUSTAINED RELEASE GLICLAZIDE TABLET

The aim of the present study was to develop a sustained release bio-adhesive matrix based Gliclazide tablet to match the in-vitro and ex-vivo experimental profile, and can be used to the treatment of Type II Diabetes Mellitus. It will be expected that single Gliclazide tablet reduce glycosylated hemoglobin and overcoming individual large fluctuation of oral bioavailability. Eleven types of tablets were formulated by wet granulation technique which contains 30 mg of Gliclazide and different concentrations of diverse bio-adhesive polymers which conforming to the USP/BP monograph. The prepared tablets were evaluated for their physicochemical parameters, bio-adhesive behavior and also in-vitro release pattern and ex-vivo residence time. Formulated F-6 tablet (300 mg) contains 30 mg Gliclazide, 90 mg Carbopol 974P NF, 155 mg Lactose, 15 mg Povidone, 5 mg Magnesium Stearate and 5 mg Talc. Carbopol based F-6 tablets showed highest significance adherence (164.1 gm) property and also exhibited greater than 300 minutes ex-vivo residence time. In-vitro release pattern of F-6 formulation was 44.74% (Mean Dissolution Time 52.86 hrs which was studied for 8 hours in phosphate buffer media at pH 7.4. Different kinetic models including zero order, first order, Higuchi and Korsmeyer pattern were applied to evaluate drug release behavior. Zero order and Korsmeyer pattern indicated most appropriate model for describing the release profile of F-6 formulation. The drug release mechanism was consequently found to be diffusion, swelling and erosion. The results point out that Carbopol 974P NF bio-adhesive matrix Gliclazide tablets have marked sustained release properties.
Show more

7 Read more

Formulation and Evaluation of Quetiapine Fumarate Loaded Carbopol 974p Mucoadhesive Microspheres for the Treatment of Schizophrenia

Formulation and Evaluation of Quetiapine Fumarate Loaded Carbopol 974p Mucoadhesive Microspheres for the Treatment of Schizophrenia

With great respect and honor, I extend my thanks to THIRUMATHI LAKSHMI BANGARU ADIGALAR,Vice President, ACMEC Trust, Melmaruvathur, for given me an opportunity and encouragement all the way in completing the study.Her excellence in providing skillful and compassionate spirit of unstinted support to our department for carrying out dissertation entitled “FORMULATION AND EVALUATION OF QUETIAPINE FUMARATE LOADED CARBOPOL 974P MUCOADHESIVE MICROSPHERES FOR THE TREATMENT OF SCHIZOPHRENIA”I got inward bound and brainwave to endure experimental investigations in novel drug delivery systems, to this extent; I concede my inmost special gratitude and thanks to Dr. S. SHANMUGAM, M.Pharm.,Ph.D. Professor, Department of Pharmaceutics, Adhiparasakthi College of Pharmacyfor the active guidance,valuable suggestions and a source of inspiration where the real treasure of my work.
Show more

150 Read more

Formulation and characterization of rifampicin microcapsules

Formulation and characterization of rifampicin microcapsules

large sized alginate beads, was used to prepare the microcapsules. Carbopol 974P and sodium alginate in different ratios (Table 1) were soaked in 1% w/v Tween-80 (10 ml) and in purifi ed water (5 ml) respectively, for overnight to form a homogenous polymer solution. The two polymers were uniformly mixed with the help of a stirrer. The core material rifampicin (0.3 g) was dissolved in methanol (1 ml) and added to the polymer solution and mixed thoroughly to form a smooth viscous dispersion. The resulting dispersion was then added in a thin stream with syringe to about 250 ml of castor oil contained in a 500 ml beaker, while stirring at 250±20 rpm. A Remi medium duty overhead stirrer with speed meter (Model RQT 124) was used for stirring. The stirring was continuous for 5 min to emulsify the added dispersion as fi ne droplets. Calcium chloride (20% w/v) solution (40 ml) was then added slowly while stirring for ionic gelation (or curing) reaction to occur. Stirring was continued for 20 min to complete the curing reaction and to produce spherical microcapsules. The microcapsules so obtained were fi ltered and washed thrice with petroleum ether (60 ml). Later they were dried in air for 3 h followed by hot air oven at 50 0 for 4 h and stored in a dessicator.
Show more

5 Read more

Novel gastroretentive mucoadhesive pulsatile tablet for Verapamil hydrochloride

Novel gastroretentive mucoadhesive pulsatile tablet for Verapamil hydrochloride

The aim of the present work was to formulate and evaluate an oral gastro retentive mucoadhesive pulsatile delivery system for treatment of arrhythmias which usually occurs in early morning hours. Gastroretentive mucoadhesive pulsatile tablets (GMP) of verapamil hydrochloride were prepared by compression coating technique using differents ratios of swelling polymers such as HPMC E15 and Carbopol 974P. Various formulations were prepared and evaluated for pre and post compression parameters. Swelling index, mucoadhesive strength and water uptake studies were performed to select an optimum concentration of polymer that would exhibit desired lag time and mucoadhesion time. Drug excipient incompatibility studies were carried out which showed no chemical interaction. From the, in vitro release studies and swelling index studies, it was observed that formulation F7 coated with 380 mg HPMC and 5 mg carbopol 974P showed optimum lag time of 5 h with highest percent drug release of 98.67% at the end of 6 th hour. The mucoadhesive strength of 48.3 g as well as the force of adhesion 0.47 N was higher for F7 as compared to other formulations. Formulation F7 showed better mucoadhesion property for a period of 5h which indicated that it would retain in the stomach for desired period. Formulation F7 was considered to be best formulation that can achieve site specific and time release of verapamil hydrochloride to treat arrhythmias effectively.
Show more

9 Read more

ENHANCEMENT OF BIOAVAILABILITY OF NORFLOXACIN MUCOADHESIVE SUSPENSION BY USING DIFFERENT GRADES OF CARBOPOL

ENHANCEMENT OF BIOAVAILABILITY OF NORFLOXACIN MUCOADHESIVE SUSPENSION BY USING DIFFERENT GRADES OF CARBOPOL

Norfloxacin sample was gifted by Hindustan Antibiotics, Pune. Pluronic F68, Soya-lecithin were purchased from Sigma Aldrich, HPMC K100M, PVP, Microcrystalline cellulose, carbopol 971P, carbopol 974P, carbopol 934P, polycarbophil were purchased from CDH, New Delhi. All the excipients and solvents were of Analytical grades and distilled deionized water was used in all the experiments.

6 Read more

Formulation and Characterisation of Clarithromycin controlled released Bioadhesive Tablets

Formulation and Characterisation of Clarithromycin controlled released Bioadhesive Tablets

Hence in present investigation, an attempt was made to deliver Clarithromycin via oral bioadhesive drug delivery system to the vicinity of absorption site by prolonging the gastric residence time of the dosage form. For the formulation of oral bioadhesive tablet various polymer used like Hydroxypropyl methylcellulose K15M, Hydroxypropyl methylcellulose K4M, Carbopol 974P, used as hydrophilic matrix forming and bioadhesive polymer in varying concentration along with Magnesium stearate, talc and Lactose as filler. Tablets were subjected to various evaluation parameters such as drug content, hardness, weight variation, friability, bioadhesive strength, swelling index, and in vitro drug release study. It was revealed that the tablets of all batches had acceptable physical parameters. Tablets of batch F9 and F12 had good Bioadhesion along with good swelling behaviours and in vitro drug release. A result of the study of individual polymers shows that the, HPMC K15M, HPMC K4M and Carbopl 974P, alone was also able to control the release in 12 hour. Release of Clarithromycin, from combination of HPMC K15M with Carbopl 974P, combination HPMC K4M with Carbopl 974P gave the good results compared to employing individual polymers. Tablets of Batch F9 and F12 were selected as an optimum batch and evaluated for further parameters like accelerated stability study and characterization using IR spectroscopy. The stability study revealed that there was no significant change in dissolution profile and bioadhesive strength for a period of one month.
Show more

7 Read more

To Study the Effect of Carbopol (Polymer) on Release Profile of an Anti-fungal Gel

To Study the Effect of Carbopol (Polymer) on Release Profile of an Anti-fungal Gel

It can be concluded from the above results and discussion that gel formulations prepared with Carbopol 934 showed acceptable physical properties, drug content and drug release. The advantage of carbopol formulations is that a wide range of release profiles can easily be achieved through variation in concentration. The results reported herein indicate that the drug release rates for the gel formulations analyzed were influenced by different concentration of carbopol (polymer) used. As compared to carbopol 934 based formulations SE8C3 formulations showed more promising results so carbopol (2%) is better gelling agent than carbopol (3%) and carbopol (4%). Acknowledgement
Show more

8 Read more

EFFET OF COMBINATION OF HPMC AND CARBOPOL 934P ON THE PROPERTIES OF THE GASTRIC FLOATING TABETS OF TIMOLOL MALEATE

EFFET OF COMBINATION OF HPMC AND CARBOPOL 934P ON THE PROPERTIES OF THE GASTRIC FLOATING TABETS OF TIMOLOL MALEATE

The purpose of the present research was to evaluate the effect of carbopol 934P on gastroretentive drug delivery system. Floating tablet containing timolol maleate were prepared by direct compression method, using three grades of polymer HPMC [K15M, K4M, K100M] and carbopol 934P. Sodium bicarbonate and citric acid was incorporated as a gas-generating agent. The floating tablets were evaluated on the basis of pre-compression and post-compression characteristics. The pre-compression characteristics such as angle of repose, bulk density, tapered density and compressibility index showed satisfactory results for all the nine formulations. The results of post-compression such as weight variation, hardness, friability and drug content estimation showed that all the nine formulations complied with the official requirement of IP. The buoyancy lag time indicated that the formulation F1, F4 and F7 without carbopol 934P were less than 8 sec, where as formulation containing carbopol 934P had greater lag time. Formulation containing only HPMC grade polymers floated less than 8 h as compared to the formulation containing HPMC with carbopol 934P floated more than 12 h. The in vitro dissolution studies indicated 94.2% drug release in 12 h by the formulations F2, F3, F5, F6, F8 and F9 containing different concentration of carbopol 934P with different grades of HPMC, when compared to 100% drug release within 9 h by the formulation F1, F4 and F7 containing only different grades of HPMC polymers. All formulation followed the Higuchi release model. The drug release from the tablets was sufficiently sustained and non-Fickian transport of the drug from tablets was confirmed. Hence it can be inferred that the inclusion of carbopol 934P can result in sustained drug delivery over 12 h, enhances the gastric floating time and also increases buoyancy lag time.
Show more

6 Read more

Sol gel transitions of carbopol by conductometric investigation: The impact of hydroxypropyl methylcellulose and benzalkonium chloride

Sol gel transitions of carbopol by conductometric investigation: The impact of hydroxypropyl methylcellulose and benzalkonium chloride

The anomalous behavior (initial decrease followed by increase at higher concentration) in case of carbopol blank solutions with increase in polymer concentration can be explained by the fact that (I) increase in polymer concentration at 0.4 and 0.5% resulted in an increase in viscosity (η), that decreases the mobility of the networks hence decreasing the conductivity [35] (II) furthermore, another school of thought suggests, the polymer network does not take part in the conduction process rather acts as a stiffener increasing its mechanical stability [36 - 39], (iii) in case of 0.6% of polymer concentration. Further addition of polymer might contribute to the macroscopic viscosity but if the network provides a continuous path through the solvent, the macroscopic viscosity may not be related to the ion mobility [14], (IV) the polymer addition may affect the extent of polymer – solvent interaction resulting in a modified polymer network with higher extent of solvation that can otherwise be termed as increasing
Show more

11 Read more

FTIR AND RAMAN SPECTROSCOPY AS A TOOL FOR ANALYZING SUSTAINED RELEASE HYDROGEL OF CIPROFLOXACIN/CARBOPOL POLYMER

FTIR AND RAMAN SPECTROSCOPY AS A TOOL FOR ANALYZING SUSTAINED RELEASE HYDROGEL OF CIPROFLOXACIN/CARBOPOL POLYMER

Carbopol polymer hydrogel may provide a gastric retention system by swelling in the stomach and inducing a pseudofed state, thereby reducing peristaltic contraction. This phenomenon is dependent on viscosity - the higher the viscosity, the lower the contraction 21 . The hydrophilic polymers may form a complex with the low solubility drug like Ciprofloxacin. The interaction between the Cipro and hydrophilic osmo-polymer C934 can be determined by several methods such as Fourier Transform Infrared (FTIR) Spectroscopy, Raman Spectroscopy, etc. In both methodologies, the interaction can be interpreted by comparing the spectra of the drug in presence and absence of the hydrophilic polymer.
Show more

10 Read more

HPMC K15M and Carbopol 940 mediated fabrication of ondansetron hydrochloride intranasal mucoadhesive microspheres

HPMC K15M and Carbopol 940 mediated fabrication of ondansetron hydrochloride intranasal mucoadhesive microspheres

The current research attempted at rationally formulating a mucoadhesive microparticulate system for the anti-emetic drug ondansetron HCl for intranasal administration with a perspective of improving the bioavailability of the drug. The research suggested that solvent evaporation remained the most relevant procedure for the fabrication of mucoadhesive microspheres of ondansetron HCl based on mucoadhesive polymers; carbopol 940 and HPMC K15M and film forming polymer ethyl cellulose. The particle size analysis indicated that all the fabricated formulations have a particle size in the range of 15-31 μm which is most convenient for the intranasal administration of the prepared formulation for enhancing bioavailability. Histopathological examination shows
Show more

9 Read more

DEVELOPMENT OF ORAL FORMULATIONS FOR COLONSPECIFIC DRUG DELIVERY USING EUDRAGIT, HPMC AND CARBOPOL AS EXCIPIENTS

DEVELOPMENT OF ORAL FORMULATIONS FOR COLONSPECIFIC DRUG DELIVERY USING EUDRAGIT, HPMC AND CARBOPOL AS EXCIPIENTS

Mesalamine was kindly provided as a gift sample from Sarex Overseas, Worli. Lactulose was prepared from the marketed preparation livoiluk manufactured by Panaecea Biotech. New Delhi, India. Hydroxy propyl methyl cellulose procured from central drug house, New Delhi. Eudragit L-100 and Eudragit E-100 was provided as a gift sample from Evonik India private Ltd. Carbopol 934PNF was provided as a gift sample from Noveon Pvt. Ltd. Castor oil was procured from central drug house, New Delhi. Methanol and Potassium di hydrogen phosphate was procured from Qualigens fine chemicals, Mumbai. Sodium hydroxide pellets, n-Octanol and Hydrochloric acid were procured from Central Drug (P) Ltd., New Delhi.
Show more

11 Read more

Development and Evaluation of Gastroretentive Controlled Release Polymeric Suspensions Containing Ciprofloxacin and Carbopol Polymers

Development and Evaluation of Gastroretentive Controlled Release Polymeric Suspensions Containing Ciprofloxacin and Carbopol Polymers

From the study it was found that both F1 and F2 in acidic buffer showed faster dissolution rate than that of phosphate buffer. Since Carbopol polymers have a pKa of 6, at pH 1.2 they are virtually un-ionised and they will start to ionize at pH 4.5. At lower pH values the polymer is not fully swollen, and there are larger regions of microviscosity. The solvent can penetrate first and deep into the glassy core and the drug is released faster before complete swelling. As the pH increases, the ionization of carboxylic acid groups causes maximum swelling, resulting in fewer and smaller regions of microviscosity. The rapid gel formation acts as a barrier for the release of drug prolonging the release. The release tends to be more diffusion controlled at lower pH region (stomach), while at higher pH (intestine), the drug release mechanism is more polymer relaxation controlled. This is due to reduction in regions of low microviscosity and the closing of micropores in the swollen polymers at higher pH [14].
Show more

17 Read more

DEVELOPMENT AND IN VIVO EVALUATION OF LOVASTATIN LOADED TRANSDERMAL PRONIOSOMAL GEL BY DESIGN OF EXPERIMENT

DEVELOPMENT AND IN VIVO EVALUATION OF LOVASTATIN LOADED TRANSDERMAL PRONIOSOMAL GEL BY DESIGN OF EXPERIMENT

Based on the previously mentioned characterization, and the results of the main effects of the adopted factorial design a candidate formula F1 with adequate Particle size, highest entrapment efficiency and high % of drug released after 5 h was selected. The selected F1 hydrated proniosomal formulation was formulated into hydrogel by adding 1% (w/w) Carbopol P 934 under magnetic stirring at 800 rpm to enhance the stability and viscosity of the system. Stirring was continued until Carbopol was dispersed. The dispersions were neutralized using triethanolamine solution. [18]
Show more

8 Read more

Journal of Applied Pharmaceutical Science

Journal of Applied Pharmaceutical Science

effect on the basic properties (Spreadability, Viscosity, Swelling, etc) of hydrogel. Depending on the cumulative % of drug permeation the formulations can be assigned in the following order F33>F22>F3>F11>F2>F1. The result clearly indicates that presence of guar gum along with Carbopol fastens drug release hence permeation through skin. There are significant correlations between viscosity and swelling of hydrogel preparations with permeability coefficient of drug. With increase in % swelling index over a period of 6 h the permeability coefficient decreased thus the swelling of the formulations is responsible to inhibit the permeation of Diclofenac potassium through skin. Viscosity also plays a significant role in drug permeation. With increase in viscosity of hydrogel, drug permeation increases. It may be due to increased contact time between skin and drug which promotes more permeation of drug.
Show more

7 Read more

FABRICATION AND IN-VITRO EVALUATION OF INTRAGASTRIC DRUG DELIVERY SYSTEM OF CEFUROXIME AXETIL

FABRICATION AND IN-VITRO EVALUATION OF INTRAGASTRIC DRUG DELIVERY SYSTEM OF CEFUROXIME AXETIL

It was concluded that the formulation F5 containing carbopol in the concentration of 90mg/tablet controlled the drug release to 12hrs (98.91) compared to other formulations. As the concentration of carbopol increased the drug release from the formulation decreased in a controlled manner which is supported from the swelling index values. % Swelling decreased with polymer concentration because high concentration of the polymer restricts its movement.

6 Read more

Formulation Development, Optimization and Characterization of Floating Beads of Captopril

Formulation Development, Optimization and Characterization of Floating Beads of Captopril

Keywords: Captopril, floating microspheres, carbopol 934p, sodium alginate, optimization, release kinetics, diffusion and control release.. Introduction.[r]

15 Read more

Oleic Acid Based Emulgel for Topical Delivery of Ofloxacin

Oleic Acid Based Emulgel for Topical Delivery of Ofloxacin

A stable, elegant and effective ofloxacin emulgel was developed using carbopol 940 and oleic acid. Ofloxacin emulgel exhibited good in-vitro drug release and viscosity. Emulgel acts as a depot of drug which will release the drug in a controlled manner at the applied site. Hence Carbopol 940 and oleic acid are recommended for the formulation and preparation of ofloxacin emulgels for topical drug delivery. ACKNOWLEDGEMENT:

8 Read more

Carbopol and Sodium Carboxymethylcellulose Based Methylsulfonylmethane Gels for Treatment of Osteoarthritis: In-vitro and In-vivo Evaluation

Carbopol and Sodium Carboxymethylcellulose Based Methylsulfonylmethane Gels for Treatment of Osteoarthritis: In-vitro and In-vivo Evaluation

Hydrogels prepared from MSM were quite stable. Due to the presence of MSM, aloe vera, and sesame oil, anti- inflammatory effect of hydrogels have been observed just in three hours after carrageenan injection. CP based formulations showed more prominent anti-inflammatory activity than NaCMC based formulations. This may be because of presence of ethanol as penetration enhancer. This can also be attributed to the presence of 1% carbopol as polymer in formulation F1-F4, which was less viscous as compared to the NaCMC. The percent inhibitions of carrageenan induced edema formation by 5% MSM gels in carbopol 940 and in NaCMC along with the marketed formulation are shown in Table 3.
Show more

8 Read more

Technological and Biopharmaceutical Characterization of Carbopol-Based Ketoprofen Emulgels

Technological and Biopharmaceutical Characterization of Carbopol-Based Ketoprofen Emulgels

The KP emulgels were white, viscous, and creamy with excellent homogeneity and pH suitable for dermal application. Increasing carbopol concentrations in the gel base led to an increase in viscosity, and all emul- gels exhibited pseudoplastic flow. The spreadability of the semi-solid dosage forms was improved by reduc- ing carbopol concentrations. Based on the in vitro drug release analysis, F18 was the formulation of choice with a maximum drug release of 99.11 ± 0.69% after 150 min. Based on the results obtained, we can suggest that the drug release from F18 can provide а prolonged thera- peutic effect, with a reduced number of applications and improved patient compliance. After 6 months of storage, the F18 formulation remained stable. Thus, carbopol emulgels are a promising topical delivery system for therapeutic agents like KP.
Show more

6 Read more

Show all 170 documents...