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Cardiac gene expression

Myocardin is sufficient and necessary for cardiac gene expression in Xenopus

Myocardin is sufficient and necessary for cardiac gene expression in Xenopus

... MLC2 expression may require transcription factors, in addition to myocardin, that are not present in animal cap ...of cardiac gene expression (Durocher et ...activating expression of ...

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Tetracycline regulated cardiac gene expression in vivo

Tetracycline regulated cardiac gene expression in vivo

... for gene transfer-based ...tetracycline-regulated gene expression system to function in vivo, we directly injected chimeric tet repressor-VP16 transactivator expression plasmids and luciferase ...

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Cardiac effects of hypoxia in the neotenous tiger salamander
Ambystoma tigrinum

Cardiac effects of hypoxia in the neotenous tiger salamander Ambystoma tigrinum

... have cardiac myocytes that undergo cell division in cell culture, and the newt Notophthalmus viridescens has been studied extensively (Mantz et ...their cardiac mass compared with matched normoxic ...Since ...

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Wnt signaling: an essential regulator of cardiovascular differentiation, morphogenesis and progenitor self renewal

Wnt signaling: an essential regulator of cardiovascular differentiation, morphogenesis and progenitor self renewal

... the cardiac crescent (Christiansen et ...the expression of early cardiac genes, including ...ectopic expression of these markers, as well as the appearance of beating cardiomyocytes (Eisenberg ...

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Atrial fibrillation risk loci interact to modulate Ca2+ dependent atrial rhythm homeostasis

Atrial fibrillation risk loci interact to modulate Ca2+ dependent atrial rhythm homeostasis

... impaired cardiac gene expression, leading to aberrant chromatin states and gene expression (33, ...develop cardiac defects that are more severe than Tbx5 or Gata4 ...

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Cortisol response to stress is associated with myocardial remodeling in salmonid fishes

Cortisol response to stress is associated with myocardial remodeling in salmonid fishes

... selected cardiac marker genes used in this study are presented in Table1. Gene-specific primers for rainbow trout -actin, proliferating cell nuclear antigen (PCNA), ventricular myosin heavy chain (VMHC), ...

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Rapid transcriptional activation and early mRNA turnover of brain natriuretic peptide in cardiocyte hypertrophy  Evidence for brain natriuretic peptide as an "emergency" cardiac hormone against ventricular overload

Rapid transcriptional activation and early mRNA turnover of brain natriuretic peptide in cardiocyte hypertrophy Evidence for brain natriuretic peptide as an "emergency" cardiac hormone against ventricular overload

... a cardiac hormone mainly produced in the ventricle, while the major production site of atrial natriuretic peptide (ANP) is the ...the gene expression of BNP, In comparison with that of ANP, in a ...

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The H3K9 dimethyltransferases EHMT1/2 protect against pathological cardiac hypertrophy

The H3K9 dimethyltransferases EHMT1/2 protect against pathological cardiac hypertrophy

... BT was supported by a Marie Curie Intra-European Fellowship (SEARCH, 253644) and a Babraham Institute Synergy grant (to HLR and WR); EL and AF were supported by Leonardo Da Vin- ci Unipharma — Graduates studentships; AA ...

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Stress dependent cardiac remodeling occurs in the absence of microRNA 21 in mice

Stress dependent cardiac remodeling occurs in the absence of microRNA 21 in mice

... to cardiac stress, and its inhibition by a cholesterol-modified antagomir has been reported to prevent cardiac hypertrophy and fibrosis in rodents in response to pressure ...of cardiac stresses, ...

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Original Article Role of miR-24 in myocardial fibrosis induced by angiotensin II

Original Article Role of miR-24 in myocardial fibrosis induced by angiotensin II

... miR-24 expression and interference recombinant lentiviral transduction in primary cardiac ...primary cardiac fibroblasts were stimulated by angiotensin II to simulate in vitro myocardial ...fibrosis. ...

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Coenzyme Q10 protects against hyperlipidemia-induced cardiac damage in apolipoprotein E-deficient mice

Coenzyme Q10 protects against hyperlipidemia-induced cardiac damage in apolipoprotein E-deficient mice

... Cardiac tissues were harvested, and protein extracts were prepared according to established methods. The extracts were separated by sodium dodecyl sulphate-polyacrylamide gel electrophoresis (SDS-PAGE, 8–15%) and ...

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Effect of Eight Weeks of Cardiac Rehabilitation Training on PPAR-α Gene Expression in CABG Patients

Effect of Eight Weeks of Cardiac Rehabilitation Training on PPAR-α Gene Expression in CABG Patients

... μl. Finally, PPAP-α mRNA expression relative to GAPDH was obtained. Sequence of the primers used in the study is shown in table 1. Circular rehabilitation program began four weeks after the surgery and lasted two ...

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A modifier screen identifies DNAJB6 as a cardiomyopathy susceptibility gene

A modifier screen identifies DNAJB6 as a cardiomyopathy susceptibility gene

... a cardiac muscle cell line derived from adult mouse atrium, were maintained in Complete Claycomb Medium (Sigma Aldrich) supplemented with 100 μM norepinephrine, 4 mM L-glutamine (Sigma Aldrich), and 10% FBS (Sigma ...

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DNA methylation regulates mouse cardiac myofibril gene expression during heart development

DNA methylation regulates mouse cardiac myofibril gene expression during heart development

... and expression of noncoding RNAs, has been demonstrated to play an important role in the regulation of gene ex- pression during the development ...of gene expression during develop- ment, and ...

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Cardiac hypertrophy is stimulated by altered training intensity and correlates with autophagy modulation in male Wistar rats

Cardiac hypertrophy is stimulated by altered training intensity and correlates with autophagy modulation in male Wistar rats

... examine cardiac function and collagen deposition in left ...physiological cardiac hypertrophy after training could be affected by other factors, such as hormonal [38], genetic [39], or other metabolic ...

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Gene recombination in postmitotic cells  Targeted expression of Cre recombinase provokes cardiac restricted, site specific rearrangement in adult ventricular muscle in vivo

Gene recombination in postmitotic cells Targeted expression of Cre recombinase provokes cardiac restricted, site specific rearrangement in adult ventricular muscle in vivo

... Western blot analysis. For immunodetection of luciferase protein, cardiac myocytes were infected, as detailed above, with AdCre, AdMA19, or AdMA19 plus AdCre at an moi of 15 for each virus. Cell lysates (50 m g of ...

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Modulation of adverse cardiac remodeling by STARS, a mediator of MEF2 signaling and SRF activity

Modulation of adverse cardiac remodeling by STARS, a mediator of MEF2 signaling and SRF activity

... of cardiac hypertrophy and in myopathic human hearts. Cardiac-specific and stress-induc- ible expression of STARS is mediated by the proximal promoter, which contains an essential MEF2-binding ...

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Aging Influences Cardiac Mitochondrial Gene Expression and Cardiovascular Function following Hemorrhage Injury

Aging Influences Cardiac Mitochondrial Gene Expression and Cardiovascular Function following Hemorrhage Injury

... Interestingly, there was an upregula- tion of 10 tRNAs located in mtDNA in the old (22-month) rats (see Figure 4). This increased level of tRNAs was con- sistent with the observation in in vitro hypoxia experiments using ...

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No evidence for cardiac dysfunction in Kif6 mutant mice.

No evidence for cardiac dysfunction in Kif6 mutant mice.

... We extracted RNA from KIF6 mutant and wild type littermates, and conducted RT-PCR with forward and reverse primers located Figure 1. Kif6 expression in tissues, cells, mutant mice and structural information. (A) ...

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A systems biology approach to understand the pathophysiological mechanisms of cardiac pathological hypertrophy associated with rosiglitazone

A systems biology approach to understand the pathophysiological mechanisms of cardiac pathological hypertrophy associated with rosiglitazone

... in gene expression profiles in the heart of a mouse model that mimics sev- eral of the characteristics of diabetes as observed in humans treated with rosiglitazone or ...of expression profiles was ...

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