Cardiac Myosin Binding Protein C
HSC70 is a chaperone for wild-type and mutant cardiac myosin binding protein C
... sudden cardiac death. The most frequently mutated gene in HCM is cardiac myosin binding protein C (MYB- PC3), accounting for more than 50% of cases in which the causative gene ...
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Cardiac Myosin Binding Protein C: At the Heart of Hypertrophic Cardiomyopathy in Humans and Domestic Cats
... of cardiac myosin binding protein C and associated mutations in the MYBPC3 gene has provided a more comprehensive understanding of hypertrophic cardiomyopathy in humans and domestic ...
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Novel splice donor site mutation in the cardiac myosin binding protein C gene in familial hypertrophic cardiomyopathy Characterization Of cardiac transcript and protein
... Additional protein interactions, localized in the region that binds to titin in vitro (27, 32), appear to be crucial for correct sarcomeric ...tated protein under control of strong viral promoters resulted ...
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Research Progress of Cardiac Myosin Binding Protein C in Dilated Cardiomyopathy and Other Cardiac Conditions
... truncated protein models of which one expresses a truncated protein and the other one a myosin-binding site that lacks myosin and myosin binding ...
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Dilated cardiomyopathy in homozygous myosin binding protein C mutant mice
... of cardiac myosin-binding protein-C (MyBP-C) in myocardial structure and func- tion, we have produced mice expressing altered forms of this sarcomere ...the cardiac ...
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Effects of hypertrophic and dilated cardiomyopathy mutations on power output by human β cardiac myosin
... generating protein machinery of the cardiac muscle sarcomere, including human β -cardiac myosin, the motor protein that powers ventricular ...non-cardiac myosin, there is ...
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Calcium, Actomyosin Kinetics, Myosin Binding Protein-C and Hypertrophic Cardiomyopathy
... Calcium, Myosin Binding Protein-C and Hypertrophic Cardiomyopathy in the basic function of cardiac ...of myosin binding protein-C is described along with how ...
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A mouse model of myosin binding protein C human familial hypertrophic cardiomyopathy
... and cardiac-specific isoforms and probably has both structural and signaling roles in the ...both myosin and titin binding domains ...The protein belongs to the immunoglobulin superfamily and ...
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A cardiac myosin light chain kinase regulates sarcomere assembly in the vertebrate heart
... the C-terminal kinase domain, identified MYLK3 as a member of the MLCK ...the protein encoded by MYLK3 ...the C terminus of the cardiac-MLCK protein (Fig- ure ...of cardiac-MLCK, ...
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The Mechanisms of the Frank-Starling Law and Familial Cardiomyopathy are Different. The Function of Myosin Binding Protein-C is Retained on Myocyte Length Increase and Force Generated is Kinase controlled
... there being a critical dimension in the sarcomere of cardiac muscle that is altered with length increase applied in diastole. It is possible but unlikely that this dimension is the separation of the thick and thin ...
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Genetic mutations and mechanisms in dilated cardiomyopathy
... (HCM), cardiac output is limited by the thickened myocardium through impaired filling and ...components myosin heavy chain and myosin binding protein C (MYH7 and MYBPC3) together ...
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Autoimmunity in Chagas' disease Identification of cardiac myosin B13 Trypanosoma cruzi protein crossreactive T cell clones in heart lesions of a chronic Chagas' cardiomyopathy patient
... human cardiac and skeletal muscle myosin were obtained from normal human heart ventricular tissue and inter- costal skeletal muscle, respectively, from a cadaveric organ donor as described ...of ...
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Functional analysis of the mutations in the human cardiac beta myosin that are responsible for familial hypertrophic cardiomyopathy Implication for the clinical outcome
... -cardiac myosin heavy chain (MHC) gene, which alter only a single amino acid residue, have been described ...-cardiac myosin heavy chain gene mutations carry greater risk of morbidity than ...
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Interactions of actin, myosin, and an actin binding protein of chronic myelogenous leukemia leukocytes
... Actin, myosin, and a high molecular weight actin-binding protein were purified from chronic myelogenous leukemia (CML) ...muscle myosin. CML leukocyte myosin was similar to other ...
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Identification of cardiac myosin peptides capable of inducing autoimmune myocarditis in BALB/c mice
... Immunization experiments in BALB/c mice with fragments of rat cardiac myosin suggested that pathogenic epitopes re- side between aa 736 and 1032 (17). According to amino acid sequence comparison, ...
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Myosin heavy chain messenger RNA and protein isoform transitions during cardiac hypertrophy Interaction between hemodynamic and thyroid hormone induced signals
... response to aortic coarctation, there was a rapid induction of the beta-MHC mRNA followed by the appearance of comparable levels of the beta-MHC protein in parallel to an increase in the left ventricular weight. ...
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The injury-induced myokine insulin-like 6 is protective in experimental autoimmune myositis
... relaxin-2 protein; RT: reverse transcriptase; TA: tibialis anterior; TBST: Tris-buffered saline with Tween; TG: transgenic; TNF: tumor necrosis factor; Tregs: regulatory T cells; WT: ...
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Properties of the muscle proteins a comparative approach
... Myosin, the major protein of the A filament, has long been known to exist in forms of different ATPase activity in fast and slow adult skeletal, foetal skeletal, cardiac and smooth muscl[r] ...
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Mouse and computational models link Mlc2v dephosphorylation to altered myosin kinetics in early cardiac disease
... DM versus SM. (C) Whole mouse heart (top) and H&E-stained sec- tions (bottom). Scale bars: 2 mm. (D) Echocardiographic measure- ments from WT (n = 6, 2 months; n = 10, 6 months; n = 10, 10 months) and DM (n = ...
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Mice Expressing Mutant Myosin Heavy Chains Are a Model for Familial Hypertrophic Cardiomyopathy
... Mutant Myh protein constitutes a small proportion of the total cardiac myosin Heart homogenates were prepared from control, 131 line, and 140 line mice, separated on a 6% acryl- amide ge[r] ...
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