Catechol-O-methyltransferase gene
No association between chronic musculoskeletal complaints and Val158Met polymorphism in the Catechol O methyltransferase gene The HUNT study
... In the HUNT 2 biobank a total of 62,664 DNA samples are stored. At the time of HUNT 2, participants were not sufficiently informed about possible genetic DNA-based research. Therefore, an extensive information campaign ...
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Effect of minor SNPs on enzymatic activity regulated by common human haplotypes of the catechol-O-methyltransferase gene
... One gene, two proteins. A single gene (Fig. 1) found on human chromosome 22 codes for two protein isoforms: soluble COMT (S-COMT) and membrane- bound COMT (MB-COMT) (Grossman et al., 1992). Two distinct ...
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Catechol O methyltransferase gene haplotypes in Mexican and Spanish patients with fibromyalgia
... including Mexicans and Spaniards. Genetic distances with corresponding analyses showed important differences between these two groups [21]. Previously, it has been recog- nized that, in the presence of COMT alleles, ...
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The influence of dopamine-beta-hydroxylase and catechol O-methyltransferase gene polymorphism on the efficacy of insulin detemir therapy in patients with type 2 diabetes mellitus
... Catechol O-methyltransferase is one of the major enzymes involved in catecholamine and estrogen deg- radation ...COMT gene have consequences in various mechanisms connected with development of ...
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The association between headache and Val158Met polymorphism in the catechol–O–methyltransferase gene: the HUNT Study
... COMT gene poly- morphism in a case-control study of 97 patients with migraine with aura and 94 healthy controls ...COMT gene was found in another case-control study of 103 patients with chronic daily ...
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Identification of candidate genes associated with fibromyalgia susceptibility in southern Spanish women: the al Ándalus project
... 1 gene) and rs2097903 (catechol‑O‑methyltransferase gene) SNPs with higher risk of fibromyalgia ...μ1 gene) might confer genetic risk of ...
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Catechol-<em>O</em>-methyltransferase Val158Met genotype and the clinical responses to duloxetine treatment or plasma levels of 3-methoxy-4-hydroxyphenylglycol and homovanillic acid in Japanese patients with major depressive disorder
... Depression is a common and disabling psychiatric disor- der with a complex etiology that includes predisposing risk genes and environmental stressors. Variations in the COMT gene, particularly the Val158Met ...
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Depression and anxiety in relation to catechol O methyltransferase Val158Met genotype in the general population: The Nord Trøndelag Health Study (HUNT)
... The catechol-O-methyltransferase (COMT) gene located on chromosome 22q11.2 contains a common functional polymorphism at codon 158. This polymorphism has been subject to a large number of ...
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Custom genotyping for substance addiction susceptibility genes in Jordanians of Arab descent
... Catechol-O-methyltransferase (COMT) is one of several enzymes that metabolises catecholamine such as dopa- mine, epinephrine and norepinephrine and play a role in the reinforcement mechanism [5,7]. ...
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Original Article Association of catechol-O-methyltransferase val158Met polymorphism with postoperative analgesic opioid use
... Nowadays, Opioid such as morphine and Fentanyl has been widely used in postopera- tion pain control and showed well effects [1]. However, the consumption of opioid in postop- eration pain control varies widely among ...
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Association between Catechol-O-methyltransferase rs4680 (G > A) polymorphism and lung cancer risk
... candidate gene ap- proach to explore the effects of genetic variations on the genetic susceptibility to lung ...the gene polymorphisms and the risk of lung ...between gene variations and cancer ...
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Linkage studies of catechol O methyltransferase (COMT) and dopamine beta hydroxylase (DBH) cDNA expression levels
... There has been intensive research on the genetic determi- nants of plasma COMT and DBH activities, and findings so far strongly suggest that the structural genes COMT and DBH encoding these proteins are the major ...
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Catechol-O-Methyltransferase (COMT) Gene (Val158Met) and Brain-Derived Neurotropic Factor (BDNF) (Val66Met) Genes Polymorphism in Schizophrenia: A Case-Control Study
... Several studies have also shown no association between COMT Val158Met (G>A) polymorphism and SCZ, approving the findings of the present study. Daniels did not find any correlation between COMT Val158Met (G>A) and ...
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Look beyond Catechol-O-Methyltransferase genotype for cathecolamines derangement in migraine: the BioBIM rs4818 and rs4680 polymorphisms study
... [4,5]. The COMT gene contains several SNPs, some of which result in a marked clinical significance. The rs4680 causes a substitution of a Valine (Val: GTG) to Methionine (Met: ATG) at codon 158 for MB-COMT ...
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An artificial neural network for membrane-bound catechol-O-methyltransferase biosynthesis with Pichia pastoris methanol-induced cultures
... heterologous gene can possibly lead to an increase in transcription and translation rate of the desired gene ...target gene copy numbers lead to higher titers for ...target gene copy number ...
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Potential link between genetic polymorphisms of <em>catechol-O-methyltransferase </em>and dopamine receptors and treatment efficacy of risperidone on schizophrenia
... Methods: A total of 690 schizophrenic patients (case group) were selected and 430 healthy people were included as the controls. All patients received risperidone treatment continuously for 8 weeks. Next, peripheral ...
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Lower Erythrocyte GST Activity in Autism Spectrum Disorder (ASD) Patients Compared to Normal Controls
... (RFC1) gene, Methylenetetrahydrofolate Reductase (MTHFR), Transcobalamin II (TCN2), Catechol-O-methyltransferase (COMT) and Glutathione S-transferase mu 1 (GSTM1) have all been shown to be ...
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Identifying molecular mechanisms of catechol o-methyltransferase activity and regulation
... We then estimated the level of pairing and free energy of target breaking (opening) for the 166 C-allelic variant mRNA and the 166 T variant using full length transcripts and truncated transcript sequences of different ...
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Stress, COMT polymorphisms, and depressive symptoms in older Australian women: an exploratory study
... One gene implicated in a number of mental health disorders including depression is catechol-O-methyltransferase (COMT), a gene which regulates catecholamine’s like dopamine, ...
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<em>COMT </em>Val158Met, but not <em>BDNF </em>Val66Met, is associated with white matter abnormalities of the temporal lobe in patients with first-episode, treatment-naïve major depressive disorder: a diffusion tensor imaging study
... the catechol-O-methyltransferase (COMT) gene, the Val66Met polymorphism of the brain-derived neurotrophic factor (BDNF) gene, and white matter changes in patients with major depres- ...
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