Cathepsin L
Extracellular cathepsin L stimulates axonal growth in neurons
... while cathepsin B-null mice did not have an obvious phenotype ...of cathepsin L and cathepsin B clearly demonstrated a brain-specific phenotype, such as neuronal death in the cerebral cortex ...
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Mutant Cells Selected during Persistent Reovirus Infection Do Not Express Mature Cathepsin L and Do Not Support Reovirus Disassembly
... in cathepsin L maturation exhibited by mutant cells selected during persistent reovirus infection likely results from an alteration of a protein specifically required for cathep- sin L activation or ...
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Processing of Capsid Protein by Cathepsin L Plays a Crucial Role in Replication of Japanese Encephalitis Virus in Neural and Macrophage Cells
... thepsin L cleavage are partially encoded, and the 3 ⬘ cyclization sequences was predicted for the flaviviruses (19), and the im- portance of the interaction for replication has been demon- strated in many ...
11
Cathepsin L Promotes Vascular Intimal Hyperplasia after Arterial Injury
... anti–cathepsin L (1:1000), and then washed before incubation with species-appropriate, fluorescently con- jugated secondary antibodies for 1 h at room ...
9
The lysosomal protein cathepsin L is a progranulin protease
... Cat L, Cat L knockout mice implicate Cat L in the pro- duction of brain neurotransmitters including neuropep- tide Y [33] and dynorphin ...Cat L also proteolytically cleaves dynamin-1 (Dnm1), ...
9
Cathepsin L Is Involved in Proteolytic Processing of the Hendra Virus Fusion Protein
... by cathepsin L, leading to fusion of the viral envelope with the endosomal membrane promoted by newly cleaved F ...of cathepsin L in Hendra virus infection as well as investigations into the ...
7
Evolutionary History of Cathepsin L (L-like) Family Genes in Vertebrates
... the L, S, and K members of cathepsin L family evolved from a common ancestral gene prior to mammalian divergence; the sequence conservation among the orthologs of different mammals was higher than ...
10
Cathepsin L increases invasion and migration of B16 melanoma
... that cathepsin L antisense clones did not display altered cell proliferation or adhe- sion to different protein ...substrates. Cathepsin L down- regulation also does not appear to be linked to ...
9
Uptake of extracellular enzyme by a novel pathway is a major determinant of cathepsin L levels in human macrophages
... furthermore, we demonstrated that both THP-1 cells, differentiated in human serum, and human alveolar macrophages take up the 43-kD proenzyme and process it to the 25-kD form. Thus, human serum contains a factor(s) that ...
9
Proteolytic processing of dynamin by cytoplasmic cathepsin L is a mechanism for proteinuric kidney disease
... cytoplasmic cathepsin L leads to cleavage of dynamin at an evolutionary con- served site, resulting in reorganization of the podocyte actin cytoskeleton and ...the cathepsin L site, or render ...
11
FOXO3a promotes gastric cancer cell migration and invasion through the induction of cathepsin L
... Here, we demonstrated that FOXO3a promotes the migration and invasion of gastric cancer through induction of cathepsin L. However, recent publications have reported that increased FOXO3a expression may ...
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Overexpression of Cathepsin L is associated with chemoresistance and invasion of epithelial ovarian cancer
... unclear. Cathepsin L (CTSL) is overexpressed in various cancers, however, the association between CTSL expression and paclitaxel resistance remains ...
7
Cathepsin L is essential for onset of autoimmune diabetes in NOD mice
... lack cathepsin L (Cat L) on the autoimmune diabetes-prone NOD inbred ...Cat L affords strong protection from disease at the stage of pancreatic ...Cat L–deficient mice, although a ...
11
Cathepsin L-mediated resistance of paclitaxel and cisplatin is mediated by distinct regulatory mechanisms
... the dynamic balance of cells and tissues, including proliferation, differentiation, migration, cell survival and angiogenesis [12]. Recent studies indicate that TGF-β may mediate drug resistance of tumor cells by ...
13
Thyroid functions of mouse cathepsins B, K, and L
... no)butane (E64), 2 mM EDTA, and 1 µ M pepstatin] for 30 minutes. After clearing by centrifugation at 10,000 g for 10 minutes at 4°C, the supernatants were used as thyroid lysates. Protein content was determined with ...
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Virtual screening and molecular docking of Anti-Antileishmanial for selected pharmacophore for visceral Leishmaniasis
... Leishmaniasis, Cathepsin like cysteine protease is an important target protein for the identification of novel lead compound of ...Leishmaniasis. Cathepsin like cysteine protease representing a major ...
6
Exploring Leishmania infantum cathepsin as a new molecular marker for phylogenetic relationships and visceral leishmaniasis diagnosis
... Results: The cathepsin L-like gene did not show any intraspecies variability among the isolates analyzed. The pair of primers proposed amplified the target deoxyribonucleic acid (DNA) of L. infantum ...
9
Patterns of gene expression in schistosomes: localization by whole mount in situ hybridization
... comprised cathepsin L as a gut marker (Bogitsh et ...the cathepsin L was provided by Dr Leonardo Farias, Centro de Biotecnologia, Instituto Butantan Sao Paulo, Brazil ; the remainder were ...
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ANISERP: a new serpin from the parasite Anisakis simplex
... Results: The AniSerp gene was found to have 1194 nucleotides, coding for a protein of 397 amino acid residues plus a putative N-terminal signal peptide. It showed significant similarity to other nematode, arthropod and ...
10
Heparanase Upregulation Contributes to Porcine Reproductive and Respiratory Syndrome Virus Release
... and cathepsin L protease were involved in regulation of PRRSV infection- induced ...and cathepsin L to upregulate and process heparanase, and then the active heparanase cleaves HS, resulting ...
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