CCR, CC chemokine receptor
Complementary action of granulocyte macrophage colony stimulating factor and interleukin 17A induces interleukin 23, receptor activator of nuclear factor κB ligand, and matrix metalloproteinases and drives bone and cartilage pathology in experimental arthritis: rationale for combination therapy in rheumatoid arthritis
... CCL: CC chemokine ligand; CCR: CC chemokine receptor; CIA: Collagen-induced arthritis; CII: Type II collagen; Ct: Cycle threshold; CXCL: Chemokine (C-X-C motif) ligand; ...
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A stable CC chemokine receptor (CCR) 5 tropic virus is correlated with the persistence of HIV RNA at less than 2 5 copies in successfully treated naïve subjects
... Studies aimed at assessing the influence and frequency of the switch of viral tropism during the course of therapy showed a low event rate in patients responding to HAART, and there have[r] ...
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Chemokine signals are crucial for enhanced homing and differentiation of circulating osteoclast progenitor cells
... CCL: CC chemokine ligand; CCR: CC chemokine receptor; CDAI: Clinical Disease Activity Index; cDNA: Complementary DNA; cFms: Receptor for colony-stimulating factor-1; CRP: ...
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Abrogation of CC chemokine receptor 9 ameliorates collagen induced arthritis of mice
... CCL: chemokine (C-C motif) ligand; CCR: CC chemokine receptor; CIA: collagen-induced arthritis; CII: type II collagen; CMTMR: 5-(and-6)-(((4-chloromethyl)benzoyl)amino) ...
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A chemokine receptor CCR 1 antagonist reduces renal fibrosis after unilateral ureter ligation
... the CC-chemokine receptor-1 (CCR1), as well as its chemokine ligands RANTES/CCL5, MIP-1 α /CCL3, and MIP-1β/CCL4, were expressed in parallel with the progression of renal ...
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Targeted disruption of the beta chemokine receptor CCR1 protects against pancreatitis associated lung injury
... CCR1 receptor deficient mice although, in this group, the rise in pancreatic MPO activity is ...CCR1 receptor causes little or no change in the severity of secretagogue- induced pancreatitis although it ...
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Developments in the scientific understanding of osteoarthritis
... IL-1 receptor antagonist (IL1RN), located on chromosome 2q13 within a 430-kilobase genomic fragment, have been shown to associate with the development of primary knee, but not hip, OA ...
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Title: Modulation of the CCR6 - CCL20 Axis: A potential therapeutic target in inflammation and cancer.
... inflammation. Inhibition of CCR6 is proposed to attenuate disease symptoms and promote recuperation of multiple inflammatory and autoimmune disorders. Prescription medicines with pharmacodynamics involving the inhibition ...
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Expression of membrane bound CC chemokine ligand 20 on follicular T helper cells in T B cell conjugates
... The cellular expression of CCL20 and its putative function in the humoral immune response are still not understood. In comparison, its partner CCR6 on B cells has been characterized and its dynamic expression has been ...
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Estrogen regulates T helper 17 phenotype and localization in experimental autoimmune arthritis
... C-C chemokine receptor 6 (CCR6) on lymph node Th17 cells as well as the expression of the corresponding C-C chemokine ligand 20 (CCL20) within lymph ...
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Relationship between epithelial-to-mesenchymal transition and the inflammatory microenvironment of hepatocellular carcinoma
... showed that HBx is involved in the upregulation of Twist expression and activation of STAT3 transcription leading to EMT in the MHCC97H and HL-7702 cell lines. In addition, HBx has been shown to activate c-Src (a ...
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Higher serum CCL17 may be a promising predictor of acute exacerbations in chronic hypersensitivity pneumonitis
... CCR4 is a CCL17 receptor preferentially expressed on Th2 cells [11]. Patients with IPF have significantly higher CCR4 expression on BAL CD4 T cells compared to patients with other interstitial lung diseases such ...
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The Equine Herpesvirus 2 E1 Open Reading Frame Encodes a Functional Chemokine Receptor
... potential chemokine recep- tors: UL33, UL78, US27, and ...alter chemokine levels in the supernatant of infected cells, possibly by a sequestration mechanism (12), potentially affecting immune responses, ...
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Activation status of mucosal associated invariant T cells reflects disease activity and pathology of systemic lupus erythematosus
... Fc receptor blocking re- agent (Miltenyi Biotec, Bergisch Gladbach, Germany), and cell surface staining was performed using the following monoclonal antibodies (mAbs) and tetra- mers: TCR pan-γ/δ-fluorescein ...
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Differential signaling mechanisms regulate expression of CC chemokine receptor-2 during monocyte maturation
... In this paper we demonstrate that a major consequence of monocyte maturation into macrophages is the selective downregulation of the chemokine receptor, CCR2, but not the related CCR1. We have further shown ...
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Blockade of CC chemokine receptor 5 (CCR5) tropic human immunodeficiency virus 1 replication in human lymphoid tissue by CC chemokines
... explain the well-characterized viral phenotype switch from CCR5- to CXCR4-tropic virus that has been observed during the late stages of HIV pathogenesis (1–8). It is important to point out however that this switch does ...
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Progranulin derivative Atsttrin protects against early osteoarthritis in mouse and rat models
... Total RNA were extracted from cultured chondrocytes using the RNeasy kit (Qiagen) and reverse transcribed into cDNA using the ImProm-II reverse transcription system (Promega). Data were normalized to the internal ...
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The C C chemokine receptor CCR3 participates in stimulation of eosinophil arrest on inflammatory endothelium in shear flow
... Chemokines are widely hypothesized to stimulate firm ad- hesion of leukocytes on endothelium in shear flow. Thus far, this has been demonstrated experimentally for exogenously added chemoattractants, but not for those ...
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Lead identification of benzimidazolone and azabenzimidazolone arylsulfonamides as CC-chemokine receptor 4 (CCR4) antagonists
... chemokine (MDC), and thymus activation-regulated chemokine (TARC) which can recruit Th2 cells from the circulation. The T cells can then migrate along this chemokine gradient to the dendritic cells. ...
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Expression of CC chemokine receptor 9 predicts poor prognosis in patients with lung adenocarcinoma
... the CC chemokine receptor family [13], CCR9 may function as an oncogene and play an im- portant role in the tumorigenesis and development of lung ...
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