CDR, complementarity determining region
Characterization of the immunoglobulin heavy chain complementarity determining region (CDR) III sequences from human B cell precursor acute lymphoblastic leukemia cells
... chain complementarity determining region (CDR)-III of B-lineage cells at various stages has provided important insights concerning B cell maturation and ...human CDR-III sequences has ...
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Bovine cryptosporidiosis: impact, host-parasite interaction and control strategies
... ferentiation; CDR: complementarity-determining region; cm: centimetre; DCs: dendritic cells; DNA: deoxyriboneucleic acid; GALT: gut associated lymphoid tissue; GM-CSF: granulocyte-macrophage ...
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Relationship between Antibody 2F5 Neutralization of HIV-1 and Hydrophobicity of Its Heavy Chain Third Complementarity-Determining Region
... its CDR H3 loop into a hydrophobic milieu ...2F5 CDR H3 mediates neutralization of HIV-1, the finding that mutations to trypto- phan were tolerated at three separate locations within the CDR H3 loop, ...
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Domain swapping of complementarity-determining region in nanobodies produced by Pichia pastoris
... In practical nanobody applications, CDRs are inserted into proper scaffolds, such as universally humanized scaf- folds (Vincke et al. 2009; Moutel et al. 2016) or scaffolds suitable for tissue imaging (De Groeve et al. ...
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Ablation of the Complementarity-Determining Region H3 Apex of the Anti-HIV-1 Broadly Neutralizing Antibody 2F5 Abrogates Neutralizing Capacity without Affecting Core Epitope Binding
... long CDR H3 loops, the unusual origins of the D(H) segment of bnAbs 2F5 (52 bp long) and 2G12 (31 bp long) suggest that making anti- bodies with specific CDR H3 loops that are effective in neu- tralizing ...
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A complete, multi level conformational clustering of antibody complementarity determining regions
... antibody complementarity-determining region (CDR) conforma- tions is an important step that drives antibody modelling and engineering, prediction from sequence, directed mutagenesis and ...
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Proline-rich tandem repeats of antibody complementarity-determining regions bind and neutralize human immunodeficiency virus type 1 particles.
... as complementarity- determining regions (CDRs), that connect the more conserved b -sheet framework structure of the immunoglobulin molecule (37, ...binding region of the surface unit glycoprotein ...
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Study on Agricultural Production in Nepal: a case Study in far Western Development Region
... At the regional level, the trend in y ield variability is somewhat different. In the CDR, MWDR, and FW DR, where yields are on average 5.9 percent above, 7.7 percent below, and 4.6 percent below the national ...
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Homologous regions of autoantibody heavy chain complementarity determining region 3 (H CDR3) in patients with pemphigus cause pathogenicity
... chain complementarity-determining region 3 (H-CDR3) of most pathogenic, but not nonpathogenic, mAbs shared an amino acid consensus ...small region (even 1 amino acid) can mediate ...
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Molecular features of the complementarity determining region 3 motif of the T cell population and subsets in the blood of patients with chronic severe hepatitis B
... When the GMSP analysis of a sample demonstrated a TCRBV family monoclonal profile (single peak), the cor- responding TCRBV gene family was selected for cloning and sequencing to characterize and determine the degree of ...
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CDR Search User Guide
... The Search by fields are all automatically wildcarded. That is, if you type "5" as the extension, CDR Search returns all extensions beginning with that digit. 5. To search for a Tenant, enter the name in ...
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2011 iswcs df cdr
... our CDR Scheme 2 here, because U does not need to receive any message, RS only needs to adapt the rate to RS– BS channel and therefore a higher rate for the transmission can be chosen considering the relay side of ...
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2011 icc af cdr
... The complexity for CDR with exhaustive search, however, is prohibitively high since we have to calculate the sum–rate for every permutation of the packets. It is necessary to propose some sub-optimal schemes which ...
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Complementarity in Time between Hydro, Wind and Solar Energy Resources in the State of Rio Grande do Sul, in Southern Brazil
... the complementarity between hydro, wind and solar pho- tovoltaic energy in the Brazilian state of Rio Grande do ...having complementarity between water, wind and solar photovoltaic schemes when ...
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Synergy between trastuzumab and pertuzumab for human epidermal growth factor 2 (Her2) from colocalization: an in silicobased mechanism
... membrane region, a tyrosine kinase domain, and a C- terminal tail harboring autophosphorylation sites that serve as docking sites for adaptor proteins ...a region that is not involved ...
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Tissue distribution and clonal diversity of the T and B cell repertoire in type 1 diabetes
... (IGH) complementarity determining region 3 (CDR3) amino acid (AA) sequences shared across the pancreatic draining lymph node (pLN, yellow), spleen (blue), and “irrel- evant” mesenteric and/or ...
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Reduced T cell repertoire restrictions in abatacept treated rheumatoid arthritis patients
... by complementarity-determining region-3 (CDR3) spectra- typing after TCR beta variable (TCRBV) gene multiplex PCRs that allow the detection of 23 functional TCRBV families starting from 500 ng of ...
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B cell repertoire expansion occurs in meningeal ectopic lymphoid tissue
... Ig-VH RepSeq. We used Ion Torrent semiconductor sequencing (Personal Genome Machine [PGM]; Life Technologies) to interrogate the Ig repertoire in this study. As this technology had not been previously used in our hands ...
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IDENTIFICATION OF ANTIBODY TARGETS USING PHOTOACTIVATED CROSS LINKERS LOCATED IN THE BINDING SITE
... Antibodies are commonly defined as glycoproteins of the immunoglobulin (Ig) superfamily produced by B lymphocytes to recognise and neutralize foreign intruders and consist of two heavy and light chains classified into ...
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A novel one-step approach for the construction of yeast surface display Fab antibody libraries
... 90% CDR sequence identity (Additional file 1: Figure S4) were also found to be the most prominent clones using the conventional library construction method of sepa- rate heavy and light chain vector construction ...
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