Cell death signaling pathway
Deregulation of the Egfr/Ras signaling pathway induces age-related brain degeneration in the Drosophila mutant vap
... neuronal cell death; glia cells remain unaffected even in the oldest flies tested (as revealed by ultrastructural analysis and using different molecular markers; unpublished ...neuronal cell ...
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Cotargeting survival signaling pathways in cancer
... myeloid cell leukemia sequence 1 (Mcl-1). Growth factor survival signaling proceeds through the PI3K pathway, a process that is amplified in cells deficient in the PTEN ...promotes cell ...
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Resveratrol modulates the Akt/GSK-3β signaling pathway in a middle cerebral artery occlusion animal model
... apoptotic cell death and consequently inhibits cell ...induces cell death by increasing caspase- 3 activity in ischemic injury ...
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Valproic acid inhibits neural progenitor cell death by activation of NF-κB signaling pathway and up-regulation of Bcl-XL
... apoptotic cell death, in other neurodevelopmental dis- orders such as tuberous sclerosis and Cowden syn- drome would be an intriguing topic to be resolved in the future ...
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Mitochondrial dysfunction and oxidative stress in aging and cancer
... mitochondrion-dependent pathway of apoptosis; (2) caspase-8 directly activates caspase-3, -7 or -6, leading to the apoptotic DNA fragmentation and cell death ...recruit death-associated ...
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Original Article Identification of genes associated with apoptosis-sensitive acute lymphoblastic leukemia responsive to ionising radiation by bioinformatics analyses
... and pathway enrichment analyses of DEGs were performed, and protein-protein interaction (PPI) network was ...Fas cell surface death receptor (FAS), were mainly enriched in the BP terms related to ...
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Interaction Between Mitochondria and Caspases: Apoptotic and Non-Apoptotic Roles
... induced cell death without inducing an inflammatory ...of cell death immunologically ...immune signaling component MAVS and the initiator caspase-8 ...and death ...
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The Jun N-terminal kinases signaling pathway plays a “seesaw” role in ovarian carcinoma: a molecular aspect
... induces cell apoptosis via ER stress /IRE1α/JNK, but also influences the generation of cell ATP resulting in cell death via the activation of ASK1 ...ROS-mediated cell apoptosis might, ...
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Interferon-stimulated gene 15 induces cancer cell death by suppressing the NF-κB signaling pathway
... NF-κB signaling pathway by downregulating the expression of IKKβ and p65, phosphorylation of p65 and ...cancer cell apoptosis by disrupting the NF-κB signaling ...
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Clofoctol and sorafenib inhibit prostate cancer growth via synergistic induction of endoplasmic reticulum stress and UPR pathways
... JNK signaling pathway, resulting in autophagic cell ...induce cell death even though there was no obvious dif- ference in phosphorylation of eIF2α (Figure ...
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Overexpression of selenoprotein H prevents mitochondrial dynamic imbalance induced by glutamate exposure
... of cell signaling events ...the cell components leading to ...of cell death, a non-receptor mediated oxidative pathway originating from mitochondrial release of cytochrome c and ...
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A p38MAPK/MK2 signaling pathway leading to redox stress, cell death and ischemia/reperfusion injury
... cellular signaling pathways are increasingly realized for the control they can exert over ...intracellular signaling molecules includ- ing mitogen-activated protein kinases (MAPKs) during IR is well ...
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Original Article Cellular transcriptomics: gelsolin negatively regulates the expression of apoptosis-associated genes and inhibits apoptosis in hepatocarcinoma cells
... P53 signaling pathway, which finally affects apoptosis through terminal apoptosis- associated factors such as caspase 3, bcl-2 and cytochrome ...mitochondrial-dependent cell death due to the ...
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The Molecular Story of COVID-19; NAD+ Depletion Addresses All Questions in this Infection
... (RAS) signaling pathway, oxidative stress and cell death, cytokines storm and endothelial dysfunction are four major pathways involved in the pathogenesis of nCoV ...
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Original Article Dihydroartemisinin and cisplatinum synergistically induced apoptosis in human lung adenocarcinoma H1299 cells
... control. Cell inhibition and apoptosis were evaluated by MTT assays and flow ...H1299 cell apoptosis compared to control group, while a higher apoptotic level was observed in DHA plus Cis treated ...
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Humanized anti-hepatocyte growth factor (HGF) antibody suppresses innate irinotecan (CPT-11) resistance induced by fibroblast-derived HGF
... including cell-cell and cell-matrix interactions, local release of soluble factors and so on ...fibroblast cell line CCD-18co conditioned medium can support the survival of colorectal cancer ...
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A Single Amino Acid Substitution in Obg Activates a New Programmed Cell Death Pathway in Escherichia coli
... Programmed cell death (PCD) is a well-known phenomenon in higher ...PCD pathway that induces characteristics that are strikingly reminiscent of eukaryotic apoptosis, such as fragmentation of DNA, ...
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Potential role of LINC00996 in colorectal cancer: a study based on data mining and bioinformatics
... KEGG pathway analysis to identify biological functions enriched among those associated ...addition, pathway analysis revealed that some cell adhesion molecules may be regulated by ...
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Breast cancer: Small molecules targeting apoptosis, a prospective approach to safe scientific success
... mitochondrial pathway of apoptosis is the major mechanism of physiological cell death in ...this pathway, proapoptotic members of the Bcl-2 family (contain only a BH3 domain) cause ...
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Review Article The circular RNA and microRNA regulatory networks in glioma
... Through a microarray analysis of 3 paired glio- ma clinical tissues with low miR-422a expres- sion, Wang et al. [22] identified that ciR-NT5E was significantly enhanced in glioma clinical samples when miR-422a was ...
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