cell reprogramming
Epigenomic plasticity enables human pancreatic α to β cell reprogramming
... β cell sig- nature genes involved in transcriptional ...β cell reprogramming could be promoted by manipulating the histone methylation signature of human pancre- atic ...display ...
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Cancer cell reprogramming: a promising therapy converting malignancy to benignity
... factor-mediated reprogramming is based on genetic and epigenetic modifications via specific gene delivery ...the reprogramming technique has been further deployed in the development of poten- tial cancer ...
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Direct cell reprogramming for tissue engineering and regenerative medicine
... high reprogramming efficiencies and can pose problems when transitioning to human subjects and clinical ...many cell phenotypes, including endothelial cells, skeletal myocytes, neuronal cells, and ...a ...
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An RNA editing fingerprint of cancer stem cell reprogramming
... from cell line lysates, 1-2 × 10 6 cells were extracted using RNeasy mini columns, and for primary cells, 5-10 × 10 4 cells were lysed and extracted using RNeasy micro col- ...
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Fluorescent tagged episomals for stoichiometric induced pluripotent stem cell reprogramming
... iPS cell lines showed normal karyotyping or com- parative genomic array analysis (Cell Line ...Stem Cell Research Committee (GESCR) and the UCSF Committee for Human ...
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Reprogramming cell fate to pluripotency: the decision making signalling pathways
... in reprogramming remains ...stimulated reprogramming after fusion of ESCs with thymocytes or MEFs, which led to the formation of ESC-like hybrid ...of reprogramming via somatic cell nuclear ...
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The miR-290-295 cluster as multi-faceted players in mouse embryonic stem cells
... of somatic cells reprogrammed into iPSCs. Lin28 was upregulated by transfection of miR-294 into Dicer-defi- cient cells, but the molecular mechanism is unknown [43]. Judson et al. [44] showed the high inductive effi- ...
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Autophagy in stem cells: repair, remodelling and metabolic reprogramming
... impairs reprogramming efficiency (Tsukamoto et ...of cell reprogramming; by contrast, rapamycin treatment at later stages, or very high concentrations of rapamycin, abolish iPSC generation, ...
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Epigenetics of induced pluripotency, the seven-headed dragon
... somatic cell reprogramming using ‘Yamanaka’ factors is evident when considering the sources of somatic cells used in reprogramming experi- ments, including liver and stomach [11], blood [12], ...
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Direct reprogramming and biomaterials for controlling cell fate
... of cell expansion and modulated the differentiation of embryonic stem ...effective cell fate ...altering cell signaling ...for cell reprogramming, and it nearly dou- bled efficiency of ...
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Induced pluripotent stem cells (iPSCs) based approaches for hematopoietic cancer therapy
... stem cell approaches are developing as a hopeful strategy to improve our knowledge of genetic association studies and the underlying molecular ...stem cell therapy and cell reprogramming ...
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Direct reprogramming of adult cells: avoiding the pluripotent state
... iPS cell reprogram- ming have shown much promise, it is still considered slow and ...and cell diversity may markedly compromise any applications in regeneration- based ...cellular reprogramming, for ...
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Active glycolytic metabolism in CD133(+) hepatocellular cancer stem cells: regulation by MIR-122
... stem cell characteristics may influence sorafenib resistance, CD133 (+) and (−) cells were treated with various concentrations of sorafenib ...sorafenib-induced cell death compared to CD133 (−) cells ...
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Metabolic recoding of epigenetics in cancer
... translocate to the nucleus in response to stress or physi- ological signals. For example, glucose deprivation causes cytosolic ACSS2 to relocate to the nucleus, where it binds to transcription factor EB (TFEB). When TFEB ...
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The platelet isoform of phosphofructokinase contributes to metabolic reprogramming and maintains cell proliferation in clear cell renal cell carcinoma
... clear cell renal cell carcinoma (ccRCC) progression include aerobic glycolysis, increased pentose phosphate pathway activity and reduced oxidative ...support cell proliferation in ...impaired ...
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Granulosa cell-derived induced pluripotent stem cells exhibit pro-trophoblastic differentiation potential
... We have also demonstrated a new, alternative method for deriving iPSCs from a limited number of parental cells. If cells with different parental origins are mixed, the parental identity of individual iPSC clones can be ...
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In vivo conversion of rat astrocytes into neuronal cells through neural stem cells in injured spinal cord with a single zinc-finger transcription factor
... All animals experiments performed in this study were in strict accordance with the guidelines of the Royan Institute Review Board and Ethics Committee. Astro- cytes were extracted from the brain of an adult male Wistar ...
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Financial report. EU budget 2010
... Reprogramming In this financial report, the term ‘reprogramming’ has the following meaning: when the state of implementation in the expenditure areas of Structural Funds, the Cohesion Fu[r] ...
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Effects of mechanical stimulation on the reprogramming of somatic cells into human-induced pluripotent stem cells
... iPSC colonies were found in every group, regardless of substrate type and stretching. However, the colonies prepared on flexible membranes without stretching were found to be unstable, with unclear edges. Moreover, their ...
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Ionizing Radiation Impairs T Cell Activation by Affecting Metabolic Reprogramming
... immune cell cytotoxicity and population change have been well studied in human and animal models, little is known about the functional alterations of the surviving immune cells after ionizing ...T cell ...
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