cellular, physiological prion protein
Glutamate receptors function as scaffolds for the regulation of β-amyloid and cellular prion protein signaling complexes
... normal physiological conditions glu- tamate mediates learning and memory, as well as other higher order integrative brain function, but pathological glutamate signaling is also known to contribute to neu- ronal ...
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Gauczynski, Sabine (2002): Characterization of the 37-kDa/67-kDa laminin receptor as the cell surface receptor for the cellular prion protein. Dissertation, LMU München: Fakultät für Chemie und Pharmazie
... PrP-related protein (Moore et ...a physiological process in a manner leading to this pathological ...PrP-like protein to be described in mammals (Moore et ...associated protein comparable to ...
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The [URE3] Prion Is Not Conserved Among Saccharomyces Species
... [URE3] prion of Saccharomyces cerevisiae is a self-propagating inactive form of the nitrogen catabolism regulator ...[URE3] prion is conserved in ...a prion isoform results from the primary sequence ...
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The biological function of the cellular prion protein: an update
... of prion diseases, Prnp knockout mice lacking PrP C were generated in order to answer the question whether the loss of physiological PrP C function would lead to neu- rodegeneration in prion ...to ...
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Prion protein and its role in signal transduction
... to cellular and tissue homeostasis, such as the molecules of the major histocompatibility complex (MHC), which have various functions beyond their classical role in presenting antigens to T cells ...scaffold ...
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Multiple effects of the cellular prion protein on tooth development
... mice were used to investigate the physiological function of PrP in tooth development. Cell proliferation and differentiation was Fig. 1. Immunohistochemical staining of PrP in human fetal (B-E) and mouse (F,G) ...
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Differential modulation of NMDA and AMPA receptors by cellular prion protein and copper ions
... could function to reduce overall cation flux through these receptors and subsequent excitotoxicity. Remarkably, overexpression of human PrP C (roughly six fold in Tg650 mice over PrP C levels in C57) [21] had an opposite ...
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Sialic Acid within the Glycosylphosphatidylinositol Anchor Targets the Cellular Prion Protein to Synapses
... taining protein G (Miltenyi Biotech) were added (10 l/ml) for 30 min, and protein G-bound antibody complexes were isolated using a MACS magnetic system (Miltenyi Biotech) at 4 ...
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Resenberger, Ulrike (2012): Das zelluläre Prion-Protein als Mediator der Scrapie-Prion-Protein- und Amyloid Beta-induzierten Neurotoxizität: Mechanismen und Entwicklung protektiver Strategien. Dissertation, LMU München: Fakultät für Chemie und Pharmazie
... β-Faltblatt-reicher Protein-Konformere ist ein charakteristisches Merkmal verschiedener neurodegenerativer Erkrankungen, wie der Prion- oder der ...in Prion-Erkrankungen sondern ebenso in anderen ...
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Attempts to convert the cellular prion protein into the scrapie isoform in cell-free systems.
... Incubation of MHM2 PrPC with PrP 27-30 in vitro under various conditions for 24 h Formation of: Incubation conditions PrPsc PrPc Additional treatment MoPrP 27-30 MoPrP 27-30 MoPrP 27-30 [r] ...
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Proteolytic shedding of the prion protein via activation of metallopeptidase ADAM10 reduces cellular binding and toxicity of amyloid-β oligomers
... precursor protein (APP) is cleaved by the sequential action of the  -secretase (  -site APP-cleaving enzyme 1; BACE1) and the multisubunit ␥ -secretase complex in the amyloidogenic pathway ...
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Production and Enzymatic Degradation of Sup35NM, a Prion-Like Protein from Yeast
... The M region and the C region alone do not form fibers in vitro, but the whole protein, NMC, does (Fig. 3). However, NMC does not form fibers as reproducibly as NM, perhaps because the large C region is not in its ...
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Cellular Prion Protein and Sexual Dimorphic Areas in Rodents Correlates with Alzheimer Disease
... We observed, as a whole, in the cerebral areas ana- lyzed, that the level of PrPC varies according to the spe- cific structure considered and with regard to the sex (Figures 1-6) [33,34]. Therefore, the data from this ...
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Expression of prion protein in the cerebrospinal fluid of patients with Parkinson's disease complicated with rapid eye movement sleep behavior disorder.
... from the mouse model demonstrated that the cleavage of PrP in peripheral nerves induced the activation of myelin repair in Schwann cells and the lack of PrP resulted in demyelination in those cells (Gasperini et al., ...
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Prions: in[PSI]t from Yeast
... the prion hypothesis and have even extended it to include a protein-only mechanism of inheritance in addition to the protein-only mechanism of infectivity seen in ...
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Secreted cellular prion protein binds doxorubicin and correlates with anthracycline resistance in breast cancer
... chemotherapy. (A) Kaplan-Meier (KM) analysis of relationships between PRNP mRNA and relapse-free survival (RFS) using neoadjuvant trial data sets from the KM plotter database. pCR, pathologic complete response; PRNP ...
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De Novo Appearance and “Strain” Formation of Yeast Prion [PSI+] Are Regulated by the Heat-Shock Transcription Factor
... mammalian prion protein, yeast prion proteins are capable of perpetuating particular confor- mational changes, forming amyloid (ordered protein ag- gregates) fibers under physiological ...
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A hydrogel biosensor for high selective and sensitive detection of amyloid-beta oligomers
... hydrogel biosensor for A β O detection was constructed. Our literature review shows that there is no study in which GO/ GNPs have been used as hydrogel biosensors for protein biomarker detection. This label-free ...
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Alzheimer's disease Aß assemblies mediating rapid disruption of synaptic plasticity and memory
... Some “physiological” effects of Aß on synaptic trans- mission, plasticity and learning have been described [55-59]. For example, extremely low concentrations of Aβ, both exogenously applied and endogenously gener- ...
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Cytosolic Prion Protein Toxicity Is Independent of Cellular Prion Protein Expression and Prion Propagation
... Inoculations. All inoculations were performed via the intracerebral route in 45- to 60-day-old mice, as previously described (24). Inocula consisted of 30 l of either brain homogenates prepared as a 2.5% (wt/vol) ...
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