cerebral ischemia and reperfusion
Ursolic acid reduces the metalloprotease/anti-metalloprotease imbalance in cerebral ischemia and reperfusion injury
... analysis. Cerebral ischemia and reperfusion injury significantly decreased the PPAR γ protein level, as indicated by a comparison of the control group with the sham group (Figure ...
12
Original Article Neuroprotective effect of A2AR knockout on cerebral ischemia/reperfusion injury via the inhibition of microglia activation
... Following cerebral ischemia and reperfusion, resident mi- croglia are reapidly activeted and mobilized to the injury site to mediate neuroinflam- ...to ischemia by 7 days demonstrated signi- ...
9
Radix Scrophulariae Aqueous Extract Seems to Exert Neuroprotective Effects on Cerebral Ischemia and Reperfusion Injury with Inhibiting Apoptosis via ERK1/2 and p-38 MAPK Pathway
... on cerebral ischemia and reperfusion (I/R) injury in oxygen glucose deprivation and reperfusion (OGD/R)-induced PC12 cells and middle cerebral artery occlusion/reperfusion ...
21
Triptolide attenuates cerebral ischemia and reperfusion injury in rats through the inhibition the nuclear factor kappa B signaling pathway
... acute cerebral ischemia/reperfusion (I/R) ...of reperfusion following middle cerebral artery ...after reperfusion, we evaluated neurological injuries, the expression of ...
9
Neuroprotective effects of curdione against focal cerebral ischemia reperfusion injury in rats
... Results: Our results showed that curdione could significantly reduce the infarct size and neuro- logical deficits, promote cognitive function recovery and recover neuronal morphologic damages in MCAO rats. It also ...
8
Resolvin D2 protects against cerebral ischemia/reperfusion injury in rats
... Cerebral ischemia/reperfusion (I/R) injury is a critical factor leading to a poor prognosis for ischemic stroke ...on cerebral I/R injury in rats. Cerebral I/R caused by middle ...
13
ASSESMENT OF THE ANTI INFLAMMATORY EFFECT OF CINEOL ON CEREBRAL ISCHEMIA REPERFUSION I/R INJURY
... and reperfusion in the brain brings a inflammating reaction that is possibly exacerbating primary stages of tissue ...global cerebral ischemia via BCCAO and then one hour of ...by reperfusion ...
9
Effects of vagus nerve stimulation on cognitive functioning in rats with cerebral ischemia reperfusion
... a cerebral ischemia/reperfusion (I/R) injury model in ...and reperfusion of the middle cerebral artery (MCAO/R) in Sprague–Dawley ...
12
Original Article Xanthotoxol inhibits cerebral ischemia/reperfusion injury-induced hippocampal neuronal cell apoptosis through suppressing the p38 MAPK and JNK signaling pathways
... show that OGD inhibits cell viability. These results are in agreement with the findings of previous studies [14, 15]. The neurons that were pretreated with XN prior to OGD/R exhib- ited increased cell viability, which ...
8
TREM2 protects against cerebral ischemia/reperfusion injury
... of cerebral ischemia injury, the role of triggering receptor expressed on myeloid cells 2 (TREM2) in the pathogenesis of ischemic stroke remains to be ...the cerebral cortex after middle ...
13
Original Article Effects of electroacupuncture at Shenting and Baihui on cAMP-PKA-CREB signaling pathways in rats with cognitive dysfunction caused by cerebral ischemia reperfusion
... Cerebral ischemia reperfusion models were obtained by middle cerebral artery occlusion. First, rats were anesthetized by intravenous injections of 300 mg/kg chloral hydrate. Th- rough midline ...
8
Original Article Bumetanide protects focal cerebral ischemia-reperfusion injury in rat
... attenuate ischemia-evoked cerebral ...protect cerebral ischemia-reperfusion injury (IRI) in vivo is ...attenuate cerebral IRI and if its protection effect might be related to the ...
8
Original Article Neuroprotective effects of resveratrol against cerebral ischemia/reperfusion injury in rats through attenuation of inflammation
... Cerebral ischemia/reperfusion (I/R) injury is closely related to stroke, which is a serious dis- ease with poor blood flow to the ...major cerebral artery is blocked by a thrombus or embolism ...
8
NEUROPROTECTIVE ACTIVITY OF ASCOPHYLLUM NODOSUM ON EXPERIMENTLLY INDUCED GLOBAL CEREBRAL ISCHEMIA/REPERFUSION INJURY IN MICE
... Global Cerebral Ischemia: Mice were anesthetized by using chloral hydrate (400 mg/kg, ...Global cerebral ischemia was induced by occluding the carotid ...global cerebral ...
8
Original Article Activation of STAT3 is involved in neuronal apoptosis in focal cerebral ischemia/reperfusion rats via Bcl 2/Fas pathway
... of reperfusion, reached peak at 3 h ...of cerebral ischemia in rats reveal that dysregulation of the Bcl-2 family of proteins can exacerbate ischemic neuronal ...of reperfusion respectively, ...
10
Original Article Role of miRNA-185 in cerebral ischemia-reperfusion injury
... to cerebral vas- cular wall lesions or hemodynamic impairment, which further results in a corresponding cere- bral tissue necrosis or softening due to isch- emia and hypoxia [1, ...after ischemia when blood ...
9
Pharmacological effects of Salvia miltiorrhiza (Danshen) on cerebral infarction
... including ischemia, inflammation and infection ...the cerebral infarction region in the ischemia-reperfusion MCAo rat ...in cerebral ischemia and reperfusion injury in the ...
6
Original Article Atorvastatin protects mouse brain against cerebral ischemia/reperfusion injury via down-regulating MMP-2 and MMP-9 expression
... by ischemia can trigger the activity of MMP-2 and MMP-9 after ischemic stroke ...of cerebral I/R injury [16-18]. During cerebral ischemia, MMP-2 and MMP-9 were highly upregulated and mediated ...
7
Original Article Pathways and protective mechanisms for cerebral ischemia-reperfusion injuries in mice
... Abstract: Ischemia-reperfusion injury (IRI) correlates with many signaling cascades. To further explore the deregu- lated genes and pathways involved in IRI, microarray data of GSE23163 was downloaded from ...
12
Reduced microvascular thrombosis and improved outcome in acute murine stroke by inhibiting GP IIb/IIIa receptor mediated platelet aggregation
... of reperfusion, brain tissue was harvested and platelet accumulation was quantified as the ipsilateral/contralateral cpm ...cal cerebral ischemia and reperfusion as described ...
11