• No results found

Chemo-resistance

LncRNA FOXD3-AS1 promoted chemo-resistance of NSCLC cells via directly acting on miR-127-3p/MDM2 axis

LncRNA FOXD3-AS1 promoted chemo-resistance of NSCLC cells via directly acting on miR-127-3p/MDM2 axis

... cisplatin resistance in ...cisplatin resistance in NSCLC cells ...cisplatin resistance via modulating autophagy ...cisplatin resistance in NSCLC ...regarding chemo-resistance in ...

12

Arsenic trioxide reduces chemo-resistance to 5-fluorouracil and cisplatin in HBx-HepG2 cells via complex mechanisms

Arsenic trioxide reduces chemo-resistance to 5-fluorouracil and cisplatin in HBx-HepG2 cells via complex mechanisms

... the chemo-resistance to 5-fluorouracil (5-FU) (50–1600 µM) and cisplatin (25–800 µM), reduced MMP, and caused the cell cycle arrest at G 0 /G 1 phase in a concentration-dependent ...multidrug ...

12

Autophagy contributes to the chemo-resistance of non-small cell lung cancer in hypoxic conditions

Autophagy contributes to the chemo-resistance of non-small cell lung cancer in hypoxic conditions

... This study has some limitations. Only single tumor cell line (A549) and single chemotherapeutic agent (cis- platin) was tested, further experiment with additional cell line and other chemotherapy agents are needed to ...

9

Nuclear basic fibroblast growth factor regulates triple negative breast cancer chemo resistance

Nuclear basic fibroblast growth factor regulates triple negative breast cancer chemo resistance

... in chemo-responsiveness is not well-defined, and is actively being investigated ...chemotherapy resistance and future tumor ...of chemo- resistance in a subset of TN breast cancers will ...

16

RelB plays an oncogenic role and conveys chemo-resistance to DLD-1 colon cancer cells

RelB plays an oncogenic role and conveys chemo-resistance to DLD-1 colon cancer cells

... The nuclear transcription factor kappa B (NF-κB) has been identified as a nuclear factor binding to the kappa light chain enhancer in B cells in 1986 [5]. The NF-κB family includes RelA (p65), RelB, c-Rel, NF-κB1 (p50 ...

16

Microenvironment mediated alterations to metabolic pathways confer increased chemo-resistance in CD133 tumor initiating cells

Microenvironment mediated alterations to metabolic pathways confer increased chemo-resistance in CD133 tumor initiating cells

... Pancreatic tumors are notoriously chemo-resistant. Further, the recurrence of these tumors results in a dismal survival statistics. Tumor initiating cells are reported to be responsible for both recurrence and ...

14

The role of SH3GL3 in myeloma cell migration/invasion, stemness and chemo-resistance

The role of SH3GL3 in myeloma cell migration/invasion, stemness and chemo-resistance

... of these stem cell markers (Figure 6B). No changes were observed in the expression of Lin28A in the cells with either overexpressed or silenced SH3GL3, when compared with their corresponding controls (data not shown). We ...

13

Clinical analysis of chemo-resistance risk factors in endometriosis associated ovarian cancer

Clinical analysis of chemo-resistance risk factors in endometriosis associated ovarian cancer

... A large number of previous studies focused on the drug resistance in OCCC. Some retrospective studies have shown that OCCC was resistant to traditional plati- num-based chemotherapy regimens with an objective ef- ...

7

Critical role of Wnt/β-catenin signaling in driving epithelial ovarian cancer platinum resistance

Critical role of Wnt/β-catenin signaling in driving epithelial ovarian cancer platinum resistance

... of chemo- resistance and CIC phenotype in many tumors, and inhibition of Wnt/β-catenin signaling is reported to increase sensitivity to chemotherapeutic agents in cancers ...regulating ...

15

A novel circulating hsa_circ_0081001 act as a potential biomarker for diagnosis and prognosis of osteosarcoma

A novel circulating hsa_circ_0081001 act as a potential biomarker for diagnosis and prognosis of osteosarcoma

... paired chemo-resistant and chemo-sensitive OS cell lines (MG63/DXR vs MG63, KHOS/DXR vs KHOS, U2OS/DXR vs U2OS), and found that hsa_circ_0081001 was significantly up-regulated in the OS cell lines, tissues ...

8

The roles of glucose metabolic reprogramming in chemo- and radio-resistance

The roles of glucose metabolic reprogramming in chemo- and radio-resistance

... and chemo-resistance [85, ...of resistance to chemotherapy and radiotherapy by sup- pressing apoptosis, such as rapamycin (Rp) ...and resistance to treatment through activation of differ- ent ...

13

Essential role for acid sphingomyelinase-inhibited autophagy in melanoma response to cisplatin

Essential role for acid sphingomyelinase-inhibited autophagy in melanoma response to cisplatin

... marked chemo-resistance to cisplatin in terms of cell viability, tumour growth and median survival of transplanted animals accompanied by reduced cisplatin- induced apoptosis; over-expression of A-SMase ...

15

Attenuation of STAT3 Phosphorylation Promotes Apoptosis and Chemosensitivity in Human Osteosarcoma Induced by Raddeanin A

Attenuation of STAT3 Phosphorylation Promotes Apoptosis and Chemosensitivity in Human Osteosarcoma Induced by Raddeanin A

... promoted chemo-resistance and MDR1 protein expression in both drug-sensitive OS cells and drug-resistant OS cells, while inhibiting STAT3 with siRNA sensitized OS cells to doxorubicin ...doxorubicin ...

12

Cancer Stem Cells in the Personalized Therapy of Colorectal Cancer

Cancer Stem Cells in the Personalized Therapy of Colorectal Cancer

... Some tissue-specific and whole genome approaches for molecular profiling of complex gene signatures of tumors and cancer cell lines have been developed in the last few years and led to the discovery of specific gene sets ...

13

Novel therapeutics: response and resistance in ovarian cancer

Novel therapeutics: response and resistance in ovarian cancer

... A number of studies have focused on the mechanisms of resistance to chemotherapy and potential strategies to overcome it. Dr Wa Xian and colleagues used ovarian cancer resection specimens to generate libraries of ...

6

Current and emerging treatment options for nasopharyngeal carcinoma

Current and emerging treatment options for nasopharyngeal carcinoma

... Despite multiple randomized studies since the US Intergroup 0099 trial, concurrent chemo-RT followed by adjuvant chemo- therapy is still the standard of care for locoregionally advanced nasopharyngeal ...

12

Knowledge and attitude regarding safe handling of chemo  therapeutic drugs among nurses: a cross sectional survey

Knowledge and attitude regarding safe handling of chemo therapeutic drugs among nurses: a cross sectional survey

... “Knowledge Knowledge and attitude regarding safe handling of chemo chemo- therapeutic drugs among nurses: a cross sectional survey”, International Journal of Current Research, Research 1[r] ...

7

Combination therapy targeting both innate and adaptive immunity improves survival in a pre-clinical model of ovarian cancer

Combination therapy targeting both innate and adaptive immunity improves survival in a pre-clinical model of ovarian cancer

... Fig. 5 CD4 + T cells are critical for the efficacy of the combination therapy. a Specific immune cell subsets (CD4 + T cells, CD8 + T cells, or CD11b + cells) were depleted to explore their relative contribution to the ...

17

Radiations and female fertility

Radiations and female fertility

... Both chemo- and radiotherapy have a relevant impact on reproductive potential, thus fertility preservation procedures should be carried out before and/ or during these ...

12

Prognostic and predictive role of CXCR4, IGF-1R and Ezrin expression in localized synovial sarcoma: is chemotaxis important to tumor response?

Prognostic and predictive role of CXCR4, IGF-1R and Ezrin expression in localized synovial sarcoma: is chemotaxis important to tumor response?

... Our findings have important potential implications dem- onstrating that together with clinical prognostic factors such as radiotherapy and age, CXCR4 and IGF-1R nu- clear expression is a strong independent adverse prog- ...

8

Show all 10000 documents...

Related subjects