chemokine receptor 2
CXCR-4 expression by circulating endothelial progenitor cells and SDF-1 serum levels are elevated in septic patients
... of chemokine expression by the target tissue as well as the expression of the respective receptors on EPC [14–21] Molecular regulators that affect both leukocyte and EPC migration and activity are known and might ...
8
Plasma VCAM1 levels correlate with disease severity in Parkinson’s disease
... CC-chemokine receptor 2; CCR5: CC- Chemokine receptor 5; CD11b: Cluster of differentiation 11B; CXCR3: CXC-chemokine receptor 3; CXCR4: CXC-chemokine ...
5
Retinal dendritic cell recruitment, but not function, was inhibited in MyD88 and TRIF deficient mice
... C-C chemokine receptor-2/C-C chemokine ligand-2 (CCR2/ CCL2) and C-X3-C chemokine ligand-1; CX3CR1, C- X3-C chemokine receptor-1 (CX3CL1/CX3CR1) [55], do not appear ...
16
Cytokines regulation of chemokine and chemokine receptor in relation to multiple sclerosis
... its receptor since astro cytes did no t express CCR2 on this astrocyte ...R 2-independent binding of CCL2 was confirmed by th e absence of intracellular signalling, evidenced by th e lack of calcium influx ...
330
Coreceptor usage of primary human immunodeficiency virus type 1 isolates varies according to biological phenotype.
... kine receptor(s) (2, 6, 9, 11, ...the receptor specificity of a set of cloned envelope glycopro- teins from primary HIV-1 ...for chemokine receptor specificity by infecting derivatives ...
10
Haplotype structure and linkage disequilibrium in chemokine and chemokine receptor genes
... CC-chemokine receptor genes (CCR3, CCR2, CCR5 and CCRL2) on chromosome 3p21, and a cluster of three CC-chemokine genes [MPIF-1 (CCL23), PARC (CCL18) and MIP-1a (CCL3)] on chromosome ...of ...
19
Acetyl-L-Carnitine downregulates invasion (CXCR4/CXCL12, MMP-9) and angiogenesis (VEGF, CXCL8) pathways in prostate cancer cells: rationale for prevention and interception strategies
... VEGF are controlled by multiple transcription factors in the tumor microenvironment, including androgen recep- tors [56] and estrogen receptors [5, 57]. Androgen regu- lation is a very important point, but since the ...
17
The role of inflammation in the development of epilepsy
... Evidence suggests that the BBB disruption contributes to astrocyte activation and gliosis. Within 24–48 h of the induction of SE, there is activation of glial fibrillary acidic protein-positive astrocytes (GFAP). The ...
12
Regulatory T cells in multiple sclerosis and myasthenia gravis
... A recent analysis of over 14,000 MS patients using ImmunoChip genotyping found abnormalities in genes in- volved in Treg IL-2 signaling, CD25, and CD127 [55]. While CD127 is expressed highly on Teff, but minimally ...
16
The Equine Herpesvirus 2 E1 Open Reading Frame Encodes a Functional Chemokine Receptor
... herpesvirus 2 (EHV-2) is a gammaherpesvirus related to other lymphotropic herpesviruses such as herpesvirus saimiri and Epstein-Barr ...protein-coupled receptor homolog, shows 31 to 47% amino acid ...
6
Th17 and Th22 cells in psoriatic arthritis and psoriasis
... and 2% 2-[4-(2-hydroxyethyl) piperazin-1-yl]ethanesulphonic acid ...at 2 × 10 6 cells/well and stimulated ex vivo with phorbol 12-myristate 13- acetate (50 ng/ml; Calbiochem, Nottingham, UK) ...
11
IL-33 signaling is essential to attenuate viral-induced encephalitis development by downregulating iNOS expression in the central nervous system
... type 2 innate lymphoid cells (ILC2), IL-33 signal- ing induces the production of Th2 cytokines such as IL-4, IL-5, and IL-13, leading to M2 macrophage polarization ...
13
X4 viruses are frequently archived in patients with long term HIV infection but do not seem to influence the “inflamm aging” process
... Il-6, D-dimers and hsPCR levels were not correlated with the presence of detectable HIV-RNA at time of testing, nor with the cumulative viremia over time. Secondary adjusted analyses were performed to test whether ...
9
Novel regulatory therapies for prevention of Graft-versus-host disease
... phase 2 clinical study approved by the Food and Drug Administration is currently underway to test the use of FC-based HSC transplantation in recipients of living donor renal allo- ...
8
Differential expression and prognostic value of the chemokine receptor CXCR4 in bronchopulmonary neuroendocrine neoplasms
... Four-micrometer sections were prepared from the paraffin blocks and floated onto positively charged slides. Immunostaining was performed by an indirect peroxidase labeling method as described previously[42]. Briefly, the ...
13
Role of dendritic cells in the induction of regulatory T cells
... T cells by immature allogeneic DCs can also drive Tr1 generation [20]. T cells cultured under stimulation by immature DCs selectively upregulate cytotoxic T-lymphocyte anti- gen 4 (CTLA4) and lose their ability to ...
10
Central memory CD8+ T lymphocytes mediate lung allograft acceptance
... Memory T lymphocytes are commonly viewed as a major barrier for long-term survival of organ allografts and are thought to accelerate rejection responses due to their rapid infiltration into allografts, low threshold for ...
15
Immunostimulatory RNA leads to functional reprogramming of myeloid-derived suppressor cells in pancreatic cancer
... CCR2: Chemokine (C-C motif) receptor 2; cDC: conventional dendritic cell; CXCR2: Chemokine (C-X-C motif) receptor 2; FDA: Food and Drug Administration; G-CSF: Granulocyte ...
16
Stromal derived factor-1 mediates the lung regenerative effects of mesenchymal stem cells in a rodent model of bronchopulmonary dysplasia
... SDF-1 plays a pivotal role in stem cell migration, adhe- sion, proliferation, survival and differentiation. Expressed in multiple cells within the lung, including endothelial and epithelial cells [32], the role of this ...
11
Lutein and zeaxanthin isomers modulates lipid metabolism and the inflammatory state of retina in obesity-induced high-fat diet rodent model
... DKO: Chemokine (C-C motif) ligand 2 (Ccl2( − / − ))/ CX3C chemokine receptor 1 (Cx3cr1( − / − )) mice on Crumbs homolog 1 retinal degeneration phenotype 8 (Crb1(rd8)) background; FFA: Free ...
9