chemokine receptor 6
Pleiotropic Immune Functions of Chemokine Receptor 6 in Health and Disease
... (chemokine) receptor 6 (CCR6) and its exclusive binding molecule CCL20 is an extremely important chemokine receptor-ligand pair which controls cell migration and immune induction during ...
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The Role of the CC ‐chemokine receptor 6, CCR6, in B cell differentiation during the humoral immune response
... CCR6 has been implicated in many areas of the immune system including the mucosa and in particular, the intestine. The first reports that described the generation of CCR6 deficient mice, to study the function of CCR6, ...
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Expression of membrane bound CC chemokine ligand 20 on follicular T helper cells in T B cell conjugates
... CC chemokine receptor 6 (CCR6) and its sole chemokine ligand CC chemokine ligand 20 (CCL20) display an emerging role in the coordination of humoral immune ...this chemokine axis ...
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Chemokine (C-X-C Motif) Receptor 4 and Atypical Chemokine Receptor 3 Regulate Vascular α1-Adrenergic Receptor Function
... The observation that AMD3100 did not affect blood pressure and fluid require- ments when administered as a pretreat- ment in the hemorrhagic shock model can be explained by its pharmacological properties. After systemic ...
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Pulsed high dose dexamethasone modulates Th1 /Th2 chemokine imbalance in immune thrombocytopenia
... The Statistical Package for the Social Sciences version 19.0 (SPSS Inc., Chicago, IL) was used for statistical analysis of experimental data. Values are presented as mean ± SD. The date of plasma chemokine levels ...
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Original Article Association between CXCL12 and CXCR4 polymorphisms and inflammatory bowel disease risk in a Guangxi Zhuang population
... Impaired regulation of gene expression or structural mutations in the coding sequence can cause chronic inflammation-related diseas- es [22]. Cai et al. [23] found that CXCL12 rs1801157G/A and CXCR4 rs2228014C/T may be ...
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In vitro chemokine (C-C motif) receptor 6-dependent non-inflammatory chemotaxis during spermatogenesis
... chemokine cycles are important for spermatogenesis [18]. Then, what is the role of CCL20-CCR6 in sper- matogenesis? Previous studies showed that CCL20 is involved in the non-inflammatory chemotaxis of sperm; thus, ...
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Complementary action of granulocyte macrophage colony stimulating factor and interleukin 17A induces interleukin 23, receptor activator of nuclear factor κB ligand, and matrix metalloproteinases and drives bone and cartilage pathology in experimental arthritis: rationale for combination therapy in rheumatoid arthritis
... GM-CSF has recently been identified as a key player in Th17-mediated inflammation [16, 17, 23, 24]. Both GM- CSF and IL-17 are produced by T cells and are critical mediators of experimental arthritis [8, 13, 19, 23, 34, ...
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Plasma VCAM1 levels correlate with disease severity in Parkinson’s disease
... Fig. 1 Analyses of potential alterations in key inflammatory targets in the peripheral blood mononuclear cells (PBMCs) of Parkinson ’ s disease (PD) patients relative to healthy donors (HDs). a Schematic depicting ...
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CXCR-4 expression by circulating endothelial progenitor cells and SDF-1 serum levels are elevated in septic patients
... angiogenic potential of EPC [14] and is involved in neu- trophil recruitment in an abdominal sepsis model [27]. A downregulation of the CXC-motive-chemokine receptor-2 on neutrophils in severe sepsis ...
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Immunostimulatory RNA leads to functional reprogramming of myeloid-derived suppressor cells in pancreatic cancer
... During tumor progression, the tumor induces a highly complex secretome, which is characteristic for the TME and for entertaining the suppressive phenotype by acceler- ated myelopoiesis, impaired differentiation, and ...
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Molecular Imaging of Chemokine Receptor CXCR4
... A very interesting method for direct imaging of CXCR4 and its interaction with its ligand CXCL12 using bioluminescence was recently developed by Luker et al. [43]. These researchers made CXCL12 fused to Gaussia ...
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SDF-1 Improves Renal Fibrosis in Type 2 Diabetes Mellitus Involving TGF-beta-mediated ECM via PI3K/AKT Signaling
... CXC chemokine receptor 4 and F4/80 were ...CXC chemokine receptor 4 and F4/80 was significantly increased in the kidney of db/db mice but not in C57BL/6 mice, which was improved with ...
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Serum markers of atherogenesis in apoE*3 Leiden mice
... (Figure 6-5), and the fact that similar experimental diets, and concentrations of antioxidants, were employed as previous studies While the reasons for this are not clear, it is possible that distinct mechanism(s) ...
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Emerging role of chemokine CC motif ligand 4 related mechanisms in diabetes mellitus and cardiovascular disease: friends or foes?
... Recently, chemokine CC motif ligand 4 (CCL4), also known as macrophage inflammatory protein-1β (MIP-1β), a member of the CC chemokine family, was suggested to play a potential role in the development and/or ...
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Increased CCL19 and CCL21 levels promote fibroblast ossification in ankylosing spondylitis hip ligament tissue
... corresponding receptor CCR7 are described to be crucially involved in the adaptive im- mune system, their primary role being the migration of monocytes/macrophages, mature dendritic cells (DCs) and naive T cells ...
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Aging, inflammation, stem cells, and bone healing
... In addition to intrinsic changes of aging, macrophages are modulated by their aging microenvironment and a poorly described number of external factors. When challenging young macrophages with aged serum, Gomez et al. ...
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Interleukin 10 producing LAG3+ regulatory T cells are associated with disease activity and abatacept treatment in rheumatoid arthritis
... C-X-C chemokine receptor type 3; CXCR5: C- X-C chemokine receptor type 5; DAS28: Disease Activity Score in 28 joints; Egr2: Early growth response gene 2; ELISA: Enzyme-linked immunosorbent ...
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Ectopic lymphoid neogenesis is strongly associated with activation of the IL 23 pathway in rheumatoid synovitis
... interpretation. Alternatively, IL-23 could act on other cell types than canonical Th17 cells in the synovial tissue. Sev- eral immunopathological studies of human synovitis in- deed reported a pronounced IL-17A staining ...
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CCR9 in cancer: oncogenic role and therapeutic targeting
... Chemokine receptors can also act as homing receptors for chemotaxis-specific cell homing to specific positions. Studies have shown that CCR9 is highly expressed in melanoma skin lesions [29], and that melanoma ...
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