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chimeric hemagglutinin

Chimeric Hemagglutinin Influenza Virus Vaccine Constructs Elicit Broadly Protective Stalk-Specific Antibodies

Chimeric Hemagglutinin Influenza Virus Vaccine Constructs Elicit Broadly Protective Stalk-Specific Antibodies

... the hemagglutinin protein in order to inhibit key steps of the virus life ...using chimeric hemagglutinin constructs that express unique head and stalk ...the hemagglutinin protein could be ...

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Chimeric Hemagglutinin Constructs Induce Broad Protection against Influenza B Virus Challenge in the Mouse Model

Chimeric Hemagglutinin Constructs Induce Broad Protection against Influenza B Virus Challenge in the Mouse Model

... ABSTRACT Seasonal influenza virus epidemics represent a significant public health burden. Approximately 25% of all influenza virus infections are caused by type B vi- ruses, and these infections can be severe, especially in ...

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Cryo electron Microscopy Structures of Chimeric Hemagglutinin Displayed on a Universal Influenza Vaccine Candidate

Cryo electron Microscopy Structures of Chimeric Hemagglutinin Displayed on a Universal Influenza Vaccine Candidate

... with chimeric HA constructs expressing con- served stalk domains in combination with different head domains are given ...to chimeric HA proteins that express the same stalk domain but varied head domain ...

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Improved Antigen Yield in Pandemic H1N1 (2009) Candidate Vaccine Viruses with Chimeric Hemagglutinin Molecules

Improved Antigen Yield in Pandemic H1N1 (2009) Candidate Vaccine Viruses with Chimeric Hemagglutinin Molecules

... In our previous study with an H5N1 virus, the replacement of all domains of the H5 HA with the corresponding domains of PR8 except for the ectodomain led to a higher HA content (124% compared to NIBRG-14) in the virus ...

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Vaccine Efficacy of Inactivated, Chimeric Hemagglutinin H9/H5N2 Avian Influenza Virus and Its Suitability for the Marker Vaccine Strategy

Vaccine Efficacy of Inactivated, Chimeric Hemagglutinin H9/H5N2 Avian Influenza Virus and Its Suitability for the Marker Vaccine Strategy

... novel chimeric H9/ H5N1 virus that expresses the entire HA1 portion from the H9N2 virus and the HA2 region of the heterosubtypic H5N8 ...The chimeric H9/H5N2 recombinant vac- cine protected immunized hosts ...

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Broadly Neutralizing Hemagglutinin Stalk Specific Antibodies Induce Potent Phagocytosis of Immune Complexes by Neutrophils in an Fc Dependent Manner

Broadly Neutralizing Hemagglutinin Stalk Specific Antibodies Induce Potent Phagocytosis of Immune Complexes by Neutrophils in an Fc Dependent Manner

... The identification of broadly neutralizing antibodies that recog- nize the conserved HA stalk has reinvigorated and energized ef- forts to develop a universal influenza virus vaccine. Multiple strat- egies are currently ...

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Indian hedgehog couples chondrogenesis to osteogenesis in endochondral bone development

Indian hedgehog couples chondrogenesis to osteogenesis in endochondral bone development

... a chimeric system to demonstrate the role of Ihh in chondrogenesis in a more physiological ...comparing chimeric growth plates that differ geneti- cally only by the presence or absence of the Ihh gene, we ...

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Contemporary Avian Influenza A Virus Subtype H1, H6, H7, H10, and H15 Hemagglutinin Genes Encode a Mammalian Virulence Factor Similar to the 1918 Pandemic Virus H1 Hemagglutinin

Contemporary Avian Influenza A Virus Subtype H1, H6, H7, H10, and H15 Hemagglutinin Genes Encode a Mammalian Virulence Factor Similar to the 1918 Pandemic Virus H1 Hemagglutinin

... of chimeric viruses differ- ing only in the HA gene (see Table S1 in the supplemental material for sources of HA ...Thus, chimeric AI viruses expressing representative HAs of different HA subtypes were ...

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Chimeric Influenza Virus Hemagglutinin Proteins Containing Large Domains of the Bacillus anthracis Protective Antigen: Protein Characterization, Incorporation into Infectious Influenza Viruses, and Antigenicity

Chimeric Influenza Virus Hemagglutinin Proteins Containing Large Domains of the Bacillus anthracis Protective Antigen: Protein Characterization, Incorporation into Infectious Influenza Viruses, and Antigenicity

... HA-PA chimeric constructs. The PA subunit of the anthrax toxin mediates attachment to, and transport of, the LF and EF subunits into the cytosol (6). The PA contains 735 amino acids and folds into four separate ...

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Cross Reaction among Antibody Pili sub unit Hemagglutinin Proteins and Outer Membrane sub unit Hemagglutinin Proteins of Shigella flexneri

Cross Reaction among Antibody Pili sub unit Hemagglutinin Proteins and Outer Membrane sub unit Hemagglutinin Proteins of Shigella flexneri

... The outer membrane protein (Omp), is known as an adhesion molecule in many species of bacteria and as well as Shigella, allowing bacteria to attach to cell receptors. [4]. Many pathogenic bacteria use a two- stage ...

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The Large Polymerase Protein Is Associated with the Virulence of Newcastle Disease Virus

The Large Polymerase Protein Is Associated with the Virulence of Newcastle Disease Virus

... the chimeric viruses ...the chimeric viruses, indicating that the F and HN genes and their homotypic interactions are not the major de- terminants of NDV virulence ...

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Influenza Virus Vaccine Based on the Conserved Hemagglutinin Stalk Domain

Influenza Virus Vaccine Based on the Conserved Hemagglutinin Stalk Domain

... cination with conventional influenza vaccines, HA2 is thought to be masked by the membrane-distal portion of HA, a bulky and highly immunogenic globular head domain. With the aim of pro- ducing a vaccine which would ...

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Human Influenza A Virus Hemagglutinin Glycan Evolution Follows a Temporal Pattern to a Glycan Limit

Human Influenza A Virus Hemagglutinin Glycan Evolution Follows a Temporal Pattern to a Glycan Limit

... glycoprotein hemagglutinin, ensures that the influenza virus is perennially both a rapidly emerg- ing virus and a major threat to public ...of hemagglutinin that many antibodies recog- ...years, ...

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Toxoplasma gondii Recombinant Antigens as Tools for Serodiagnosis of Human Toxoplasmosis: Current Status of Studies

Toxoplasma gondii Recombinant Antigens as Tools for Serodiagnosis of Human Toxoplasmosis: Current Status of Studies

... Chimeric products are a new kind of diagnostic tool for the detec- tion of anti-T. gondii-specific antibodies in human serum sam- ples. A single recombinant chimera contains different immunore- active epitopes ...

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Expression of human immunodeficiency virus type 1 (HIV-1) gag, pol, and env proteins from chimeric HIV-1-poliovirus minireplicons.

Expression of human immunodeficiency virus type 1 (HIV-1) gag, pol, and env proteins from chimeric HIV-1-poliovirus minireplicons.

... A pulse-chase analysis of the protein expression from the chimeric genomes demonstrated the initial rapid proteolytic processing of the polyprotein from the chimeric genomes to give HIV-[r] ...

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A Novel Self-Replicating Chimeric Lentivirus-Like Particle

A Novel Self-Replicating Chimeric Lentivirus-Like Particle

... the chimeric virus vaccine prototype described here utilizes the RNA genome from the alphavirus Venezuelan equine encephalitis virus (VEE) encoding a subset of lentivirus gene products sufficient for self-assembly ...

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Influenza Virus Hemagglutinin Stalk Specific Antibodies in Human Serum are a Surrogate Marker for In Vivo Protection in a Serum Transfer Mouse Challenge Model

Influenza Virus Hemagglutinin Stalk Specific Antibodies in Human Serum are a Surrogate Marker for In Vivo Protection in a Serum Transfer Mouse Challenge Model

... I nfluenza viruses can cause severe human respiratory disease and are a significant burden to public health (1, 2). Seasonal influenza virus vaccines are currently the most effective form of prophylaxis against disease (3). ...

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Evolutionary patterns of RNA based gene duplicates in Caenorhabditis nematodes coincide with their genomic features

Evolutionary patterns of RNA based gene duplicates in Caenorhabditis nematodes coincide with their genomic features

... We compared chromosome positions of retrocopies identified using different methods, and found only a small portion of them overlapped (data not shown). The number of overlapped retrocopies seems to correlate with their ...

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Mutations in Influenza A Virus Neuraminidase and Hemagglutinin Confer Resistance against a Broadly Neutralizing Hemagglutinin Stem Antibody

Mutations in Influenza A Virus Neuraminidase and Hemagglutinin Confer Resistance against a Broadly Neutralizing Hemagglutinin Stem Antibody

... IAV has two surface glycoproteins, hemagglutinin (HA) and neuraminidase (NA). HA helps the viral genome enter the host cytoplasm through fusion of the viral membrane with the intracellular endosomal membrane (3). ...

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A Chimeric Human-Bovine Parainfluenza Virus Type 3 Expressing Measles Virus Hemagglutinin Is Attenuated for Replication but Is Still Immunogenic in Rhesus Monkeys

A Chimeric Human-Bovine Parainfluenza Virus Type 3 Expressing Measles Virus Hemagglutinin Is Attenuated for Replication but Is Still Immunogenic in Rhesus Monkeys

... Additional chimeric recombinant PIVs expressing the measles virus F glycoprotein with or without HA will also be generated, and their immunogenicity and efficacy will be ex- amined in animal ...

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