chitinase 3-like 1
Chitinase 3 like 1 expression by human (MG63) osteoblasts in response to lysophosphatidic acid and 1,25 Dihydroxyvitamin D3
... Chitinase 3-like 1, otherwise known as YKL-40, is a secreted glycoprotein purported to have a role in extracellular matrix metabolism. The first mammalian cell type found to express YKL-40 was ...
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Chitinase 3–like–1 and its receptors in Hermansky Pudlak syndrome–associated lung disease
... complex 3 (BLOC-3). The prototypic chitinase-like protein chitinase 3–like–1 (CHI3L1) plays a protective role in the lung by ameliorating cell death and stimulating ...
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Chitinase 3-like 1 induces survival and proliferation of intestinal epithelial cells during chronic inflammation and colitis- associated cancer by regulating S100A9
... Many host-factors are inducibly expressed during the development of inflammatory bowel disease (IBD), each having their unique properties, such as immune activation, bacterial clearance, and tissue repair/remodeling. ...
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Chitinase-3-like 1 protein (CHI3L1) locus influences cerebrospinal fluid levels of YKL-40
... highly correlates with CSF ptau [13]. YKL-40 is a secreted glycoprotein, encoded by chitinase-3-like 1 protein (CHI3L1), expressed in astrocytes and associ- ated with neuroinflammatory ...
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Chitinase 3-like-1 is produced by human Th17 cells and correlates with the level of inflammation in juvenile idiopathic arthritis patients
... malian chitinase (AMCase) [5], oviduct-specific gly- coprotein [6], and stabilin-1-interacting chitinase-like protein ...them chitinase 3-like-1 (CHI3L1) is the ...
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Chitinase 3 like 1 is induced by Plasmodium falciparum malaria and predicts outcome of cerebral malaria and severe malarial anaemia in a case–control study of African children
... Chitinase 3-like 1 (CHI3L1) is a 40 kDa secreted glyco- protein from the highly conserved 18 glycosyl hydrolase ...lacks chitinase activity due to altered active site residues ...
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Chitinase 3-like 1-CD44 interaction promotes metastasis and epithelial-to-mesenchymal transition through β-catenin/Erk/Akt signaling in gastric cancer
... Chitinase 3-like-1 (CHI3L1, also called YKL-40 in humans and BRP-39 in mice) is a member of the 18 gly- cosyl hydrolase gene family that contains true chitinases and ...
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Thymosin beta 4 treatment improves left ventricular function after myocardial infarction and is related to Up-regulation of chitinase 3-like-1 in mice
... Formalin fixed paraffin-embedded tissue samples were cut in 5 μm thickness and stained with hematoxylin and eosin for histological evaluation. Infarct sizes were determined by measuring the length of the infarct area ...
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Role of genetic variations of chitinase 3-like 1 in bronchial asthmatic patients
... Asthmatic patients underwent fiberoptic bronchoscopic examinations during ICS treatment. Asthmatic bron- chial lavage fluids (BLF) were obtained from (i) patients harboring CC (wild type) of rs4950928; (ii) patients har- ...
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Atherosclerosis is exacerbated by chitinase-3-like-1 in amyloid precursor protein transgenic mice
... of chitinase-3-like-1 (Chi3l1) is increased in the APPsw-Tg mouse artery and Chi3l1 mediates endothelial cell (EC) inflammation and vascular smooth muscle cell (VSMC) activation, which in turn ...
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Suppression of metastasis through inhibition of chitinase 3-like 1 expression by miR-125a-3p-mediated up-regulation of USF1
... Chi3L1 is known as a metastatic biomarker in patients with malignant tumors [21, 36]. Through GWAS/OMIM/DEG analysis, we found that Chi3L1 is significantly associated with 38 cancers. Among these cancers, eight (red ...
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Promoter polymorphisms in the chitinase 3 like 1 gene influence the serum concentration of YKL 40 in Danish patients with rheumatoid arthritis and in healthy subjects
... A total of eight SNPs located within the promoter or coding regions of the CHI3L1 gene was analysed. Geno- typing was performed using real-time polymerase chain reaction (rt-PCR) with TaqMan ® SNP Genotyping Assays ...
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Chitinase 3 like 1 is a biomarker of acute kidney injury and mortality in paediatric severe malaria
... type 1 diabe- tes reduced NO in the blood correlated with elevated CHI3L1 [42], and plasma CHI3L1 was negatively asso- ciated with nitric-oxide mediated vasodilatory capacity in adults with obstructive sleep apnea ...
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Molecular biomarkers in multiple sclerosis
... CHI3L1: Chitinase-3-like-1; CIS: Clinically isolated syndrome; CNS: Central nervous system; CSF: Cerebrospinal fluid; CXCL13: C- X-C motif chemokine-13; DNA: Deoxyribonucleic acid; Ds: ...
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Transcriptomic analysis of fetal membranes reveals pathways involved in preterm birth
... CHI3L1: Chitinase 3 like 1; CLAP: Latin American Center for Perinatology; CXCL10: C-X-C motif chemokine ligand 10; CXCL2: C-X-C motif chemokine ligand 2; DE: Differentially expressed; DLX5: ...
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Vascular heterogeneity and targeting: the role of YKL-40 in glioblastoma vascularization
... named chitinase 3-like 1 (Chi3l1) [15-18], has emerged as a potential mediator of GBM ...of chitinase-like proteins. However, YKL-40 lacks chitinase/ hydrolase activity ...
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Urinary chitinase 3 like protein 1 for early diagnosis of acute kidney injury: a prospective cohort study in adult critically ill patients
... We must speculate on the source of CHI3L1. Upon renal stress or damage, this protein is secreted by mac- rophages within the kidney [46], while NGAL is secreted by specific cells of the distal nephron [45]. Another ...
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Diagnosis of cardiac surgery-associated acute kidney injury: differential roles of creatinine, chitinase 3-like protein 1 and neutrophil gelatinase-associated lipocalin: a prospective cohort study
... Our study has several limitations. First, it is limited in being a single-centre study in elective cardiac surgery patients. However, baseline characteristics and the inci- dence of AKI suggest that our population is ...
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Distribution of Chitinolytic Enzyme in the Organs and Molecular Cloning of a Novel Chitinase Gene from the Kidney of Marbled Rockfish Sebastiscus marmoratus
... a chitinase insertion domain, a linker region, and a chitin binding domain, and the catalytic domain contained a sequence peculiar to the active site of GH family 18 chitinase, DXXDXDXE ...SmChi-2, ...
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YKL-40 (Chitinase 3-like I) is expressed in a subset of astrocytes in Alzheimer’s disease and other tauopathies
... molecules in biofluids from patients at different AD stages has expanded our understanding about the type of im- mune responses observed in neurodegenerative diseases. A variety of cytokines, chemokines and other ...
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