Clopidogrel bisulphate
FORMULATION AND EVALUATION OF CLOPIDOGREL BISULPHATE FLOATING TABLETS
... Clopidogrel bisulphate floating tablets were designed to overcome the gastric bleeding, drug resistance and oral bioavailability problem of the drug by keeping the drug in absorption window for prolonged ...
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Method Development and Validation of Clopidogrel Bisulphate by Reverse Phase-HPLC in Bulk and Pharmaceutical Dosage Forms
... of Clopidogrel bisulphate was prepared by dissolving a quantity of Clopidogrel bisulphate hydrochloride equivalent to ...of Clopidogrel bisulphate in ...
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Formulation and evaluation of trimetazidine hydrochloride and clopidogrel bisulphate multi unit solid dosage forms
... A stock solution of 100mg/100ml of trimetazidine HCl in phosphate buffer pH6.8 was prepared. Then a serial dilution were done to obtain solutions in the concentration ranging from 10 to 100µ g/ml. The absorbance of those ...
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FORMULATION AND EVALUATION OF ORODISPERSIBLE DOSAGE FORMS INCORPORATING DRUG NANOPARTICLES CONTAINING CLOPIDOGREL BISULPHATE
... ABSTRACT: Clopidogrel bisulphate (CB) is the rate of dissolution often controls a sparingly soluble orally administered drug and the rate of ...satisfactory clopidogrel excipient compatibility ...
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Chemometric Simultaneous Estimation of Clopidogrel Bisulphate and Aspirin from Combined Dosage Form
... of clopidogrel bisulphate and aspirin in their combined dosage tablet ...their clopidogrel bisulphate and aspirin ...for clopidogrel bisulphate and aspirin were found to be in ...
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Development and validation of stability indicating RP-HPLC method for the determination of clopidogrel bisulphate in bulk and its dosage forms
... Clopidogrel bisulphate, chemically (+)-(s)-α-(2-chlorophenyl)-6,7-dihydrothieno[3,2-c] pyridine-5(4H)-acetic acid methyl ester sulphate is a potent oral antiplatelet agent often used in the treatment of ...
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Development and Validation of a Reversed-phase HPLC Method for Simultaneous Determination of Aspirin, Atorvastatin Calcium and Clopidogrel Bisulphate in Capsules
... A simple, accurate, rapid and precise isocratic reversed-phase high-performance liquid chromatographic method has been developed and validated for simultaneous determination of aspirin, atorvastatin calcium and ...
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EFFECT OF LUBRICANTS ON THE STABILITY OF CLOPIDOGREL BISULPHATE TABLETSMuhammad Amer, Zubair Saeed, Saeed Ur Rashid Nazir*, M. Nadeem3, Misbah SultanaDOWNLOAD/VIEW/http://doi.org/10.5281/zenodo.221662
... Clopidogrel bisulphate, Lactose SD, Avicel-102 were sieved through mesh 30 and lubricants through mesh ...60. Clopidogrel bisulphate, lactose SD, Avicel-102 were mixed in a polythene bag by ...
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Development and Evaluation of Clopidogrel Bisulphate Multi-Unit Floating Mini-Tablets
... The release of clopidogrel bisulphate from all the mini tablet formulation was found to be slow and sustained. The in-vitro drug release profiles of the formulations prepared with hydrophobic polymer, ...
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SEPARATION AND DETERMINATION OF PROCESS-RELATED IMPURITIES OF CLOPIDOGREL BISULPHATE BY RP-HPLC
... separate Clopidogrel bisulphate and its process related impurities in the drug ...of Clopidogrel bisulphate and its process related impurities, an attempt was made with a C18 column using ...
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FORMULATION AND EVALUATION OF CLOPIDOGREL BISULPHATE TRANSDERMAL PATCHES USING VEGETABLE OILS AS PERMEATION ENHANCER
... Orally Clopidogrel bisulphate has a short elimination half-life (7-8 ...of Clopidogrel bisulphate using vegetable oils as permeation enhancer by using solvent evaporation technique for ...
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Determination of Drug Clopidogrel Bisulphate in Pure and Pharmaceutical Forms Spectrophotometrically
... the increase in absorbance as a function of time was measured at 610 nm. The initial rate of the reaction (ν) at different concentrations was evaluated by measuring the slope of the tangent to the absorbance-time plot. ...
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Challenges in Simultaneous Analysis of Hydrolytically Sensitive Ester drugs in Combined Dosage Forms
... and clopidogrel bisulphate has been used in the study to demon- strate limitations of popular Absorbance Ratio method commonly used for simultaneous determi- nation by UV ...conditions, clopidogrel ...
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DEVELOPMENT AND VALIDATION OF UVSPECTROPHOTOMETRIC METHOD FOR ESTIMATION OF METOPROLOL IN BULK AND TABLET DOSAGE FORM
... 5. K. L. Kunturkar, Hemant Kumar Jain Development and validation of UV spectrophotometric method for determination of S (-) metoprolol succinate and Clopidogrel Bisulphate in bulk and tablet dosage form, ...
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Advance reverse phase high performance liquid chromatography method for determination of clopidogrel in pharmaceutical formulation
... Rapid and accurate reverse phase high performance liquid chromatography method is described for determination of clopidogrel bisulphate from the pharmaceutical dosage form. It was observed that chromatopak ...
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Comparison of prasugrel and clopidogrel reloading on high platelet reactivity in clopidogrel loaded patients undergoing percutaneous coronary intervention (PRAISE HPR): a study protocol for a prospective randomized controlled clinical trial
... of clopidogrel has been well established, it exhibits pharmacodynamic variability in diverse conditions which can be due to the loss-of-function CYP2C19 allele, drug- drug interactions or clinical factors ...after ...
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Modern role for clopidogrel in management of atrial fibrillation and stroke reduction
... or clopidogrel, to newly developed orally available antithrombotics like the direct thrombin inhibitor dabigatran, or the Factor Xa-inhibitor ...of clopidogrel in patients with AF and at risk of stroke, ...
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Costs and outcomes associated with clopidogrel discontinuation in Medicare beneficiaries with acute coronary syndrome in the coverage gap
... Our study has several of the limitations associated with observational data. First, our findings are only reflective of a single Medicare Part D plan and primarily capture outcomes and costs for patients with ACS who are ...
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GC/MS, FTIR and NMR Studies for the Identification and Characterization of Clopidogrel Bisulfate Degradation Products
... Though these methods already exist in the literature, none of the methods carried out studies to isolate and characterize degradation products of Clopidogrel bisul- fate formed by hydrolysis or oxidation under ...
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Statins significantly reduce mortality in patients receiving clopidogrel without affecting platelet activation and aggregation: a systematic review and meta-analysis
... of clopidogrel after administration of a load- ing dose, which reduced by ...of clopidogrel, regardless of the type of ...and clopidogrel, regardless of types of statin. For one thing, ...
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