Co-stimulatory molecule
The co-stimulatory molecule B7-H3 promotes the epithelial- mesenchymal transition in colorectal cancer
... B7-H3, first recognized as a co-stimulatory molecule, is abnormally expressed in cancer tissues and is associated with cancer metastasis and a poor prognosis. However, as an initial event of ...
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Original Article The clinical significance and contribution of the co-stimulatory molecule B7-H1 in human esophageal cancer
... The co-stimulatory molecule B7-H1 is a newly discovered and important member of the B7 family ...B7-H1 molecule is not yet clear, the role and mechanism of B7-H1 molecule in tumor ...
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cd277 is a Negative Co-stimulatory Molecule Universally Expressed by Ovarian Cancer Microenvironmental Cells
... Based on the sequence and structural similarity of CD277 and B7-H4, we hypothesized that CD277 could also act as a negative co-stimulatory molecule that regulates T cell activation. To define the ...
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Original Article Expression of co-stimulatory molecule B7-H3 in patients with recurrence spontaneous abortion
... of co-stimulatory molecules, and its expression level will increase during gestational process, which has a posi- tive effect on normal pregnancy because of its negative regulation with reducing the ...
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Blockade ofthe negative co stimulatory molecules PD 1 and CTLA 4 improves survival in primary and secondary fungal sepsis
... negative co-stimulatory PD-1:PD-L1 pathwaycould reverse immune dysfunction and improve survival in primary fungal infections and in secondary fungal sepsis occurring after bacterial ...negative ...
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Activation of mixed glia by A beta specific Th1 and Th17 cells and its regulation by Th2 cells
... and co-stimulatory molecule ...affect co-stim- 577 ulatory molecule expression by microglia, but they were able to 578 inhibit the activation of glia induced by Th17 ...
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T cells from patients with Candida sepsis display a suppressive immunophenotype
... 3 Co-stimulatory molecule expression and markers related to cell activation on CD4 and CD8 T ...a co-stimulatory molecule that is necessary for optimal T cell ...
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Binding immunoglobulin protein resolves rheumatoid synovitis: a xenogeneic study using rheumatoid arthritis synovial membrane transplants in SCID mice
... Immunohistological assessment of the RASM tissue sec- tions showed significantly reduced expression of the co- stimulatory molecule CD86 (mean visual score ± stan- dard error: HSA 1.86 ± 0.46, n = 7 ...
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T cell co stimulatory pathways in autoimmunity
... by co- stimulatory molecules. The most prominent co-stimulatory molecule is CD28, which controls the activation of naïve and memory T cells by antigen presented on professional ...
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Original Article Role of biphasic changes in splenic dendritic cell activity in a mouse model of multiple organ dysfunction syndrome
... of co-stimulatory and co-inhibitory mole- cules on DCs at different stages during MODS progression revealed that the level of CD86 co- stimulatory molecule in the normal group ...
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Immunoregulation of bovine macrophages by factors in the salivary glands of Rhipicephalus microplus
... Co-stimulatory molecule mRNA profiles of in vitro dif- ferentiated bovine macrophages were assayed by quanti- tative real-time PCR after 1, 6, or 24 hrs of treatment with or without 1, 5, or 10 μ ...
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Effector function of CTLs is increased by irradiated colorectal tumor cells that modulate OX 40L and 4 1BBL and is reversed following dual blockade
... To determine if radiation-induced expression of OX- 40L and 4-1BBL plays a direct role in enhanced tumor cell susceptibility to lysis by CTLs, we conducted CTL cytolysis experiments in combination with molecu- lar ...
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Tissue Restricted Adaptive Type 2 Immunity Is Orchestrated by Expression of the Costimulatory Molecule OX40L on Group 2 Innate Lymphoid Cells
... the co-stimulatory molecule ICOSL on ILC2s and ICOS on T cells promotes Treg cell accumulation following IL-33 administration (Molofsky et ...the co-stimulation of T cells, though its role in ...
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A DAF 3 co Smad molecule functions in Haemonchus contortus development
... In H. contortus, Hc-DAF-3 was identified as a typical member of the co-Smad family. Its MH1 domain has relatively high identities to homologues from a range of species, while the MH2 domain is more divergent. As ...
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Turning T cells on: epigenetically enhanced expression of effector T-cell costimulatory molecules on irradiated human tumor cells
... PBMCs from HLA-A2+ donors were purchased from Hemacare (Van Nuys, CA) for the generation of antigen specific CTLs as described elsewhere [4,55,56]. These leukapheresis samples, derived from HLA-A2+ patients, were ...
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Influence of Annealing on Pt Electrocatalyst: Theoretical Approach to Estimate CO Tolerance
... its CO tolerance. Using the same theoretical model for investigating CO tolerance of a catalyst, we explored how temperature of annealing affects CO poisoning of a platinum whiskerette, a nanoobject ...
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Original Article B7-2 gene silencing by lentivirus-mediated delivery of shRNA reduces progression of experimental lupus nephritis
... RNA interference (RNAi), a sequence-specific post-transcriptional gene silencing process mediated by 21~23 bp double-stranded RNA (dsRNA), can trigger the degradation of homolo- gous mRNA as well as down-regulation of ...
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Role of the redox responsive transcription factor, NRF2 in immune cell function
... 28 inflammatory DCs play vital roles in Th2 differentiation during infection (Kool et al., 2012). Moreover, DCs matured under suboptimal or inflammatory conditions instruct the polarisation of CD4 T cells to Th2 ...
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Annexin A2 antibodies but not inhibitors of the annexin A2 heterotetramer impair productive HIV 1 infection of macrophages in vitro
... In summary, an anti-A2 antibody targeting the N- terminus of A2 successfully blocked productive HIV-1 in- fection of macrophages in vitro, but A2t-targeting drugs did not, indicating that A2 may promote HIV-1 infection ...
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First Principles Calculation of CO and H2 Adsorption on Strained Pt Surface
... a CO molecule. The CO molecule is put into a vacuum layer far from the surface and is adsorbed on the top site of a Pt (111) surface in ...isolated CO molecule. No interaction ...
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