Cochlear Inner Hair Cells
Position-dependent patterning of spontaneous action potentials in immature cochlear inner hair cells
... We have investigated the origin of action potential activity in IHCs during the first postnatal week in mice, rats and gerbils at 35-37°C and in perilymph-like extracellular solution (1.3 mM Ca 2+ and 5.8 mM K + ) using ...
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Association of intracellular and synaptic organization in cochlear inner hair cells revealed by 3D electron microscopy
... The cells of the vertebrate cochlea provide an ideal model system in which to evaluate the functional context of distinct populations of highly specialised ...inside cells that occur after cochlea damage, ...
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Development and Function of the Voltage-Gated Sodium Current in Immature Mammalian Cochlear Inner Hair Cells
... Voltage-gated Na + channels are complexes of an a subunit and, in most cases, auxiliary b-subunits [14–16]. While the a-subunit determines the main properties of the Na + channels (ion permeability and kinetics) the b ...
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Tricellulin deficiency affects tight junction architecture and cochlear hair cells
... extracellular cochlear fluids, endolymph and perilymph, are separated by tight junctions that outline the scala media and reticular ...the inner ear epithelia of the mutant animals, which developed rapidly ...
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Tympanic border cells are Wnt responsive and can act as progenitors for postnatal mouse cochlear cells
... stem cells in the gastrointestinal system (Barker et ...in inner ear progenitor cells are incompletely ...of cochlear progenitor ...characterized cochlear cell population: tympanic ...
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Animal Model of Sensorineural Hearing Loss Associated with Lassa Virus Infection
... the cochlear hair cells and, strikingly, significant degeneration of the spiral ganglion cells of the auditory ...the inner ear of the mice with SNHL supported the phenotypic loss of ...
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Cochlear outer hair cells undergo an apical circumference remodeling constrained by the hair bundle shape
... According to Laplace’s law, a higher membrane curvature corresponds to a lower membrane tension, or a larger pressure applied across the membrane, or both. The asymmetrical distributions adopted by myosin II and myosin ...
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Effect of Deliberate Ingestion of Organophosphate Pesticide on Distortion Product Oto Acoustic Emissions (DPOAE)
... Hensen’s cells. The latter cells are in close connection with the Deiter’s cells, which are located under the OHCs, and thus the target is ...solvent-induced cochlear damage has not yet ...the ...
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Stem cells for the replacement of inner ear neurons and hair cells
... toward hair cells from neural stem cells transplanted into the inner ear of guinea pigs (Hu et ...the cells were placed in the scala tympani, which makes it difficult to assess whether ...
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Connexin-Mediated Signaling in Nonsensory Cells Is Crucial for the Development of Sensory Inner Hair Cells in the Mouse Cochlea
... sensory hair cells are embedded in a matrix of epithelial nonsensory cells, which are crucial for normal cochlear function (Monzack and Cunningham, ...Nonsensory cells in the mammalian ...
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Distinct capacity for differentiation to inner ear cell types by progenitor cells of the cochlea and vestibular organs
... vestibular hair bundles, are immunoreactive for α 3 acetylated tubulin (B, multiple cells with multiple tubulin-positive structures, ...(F-I) Cochlear-derived HC-like cells, recognized by ...
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MPZL2, Encoding the Epithelial Junctional Protein Myelin Protein Zero-like 2, Is Essential for Hearing in Man and Mouse
... outer hair cells and supporting cells and degeneration of the organ of ...the inner-ear epithelium and result in loss of structural integrity of the organ of Corti and progressive degeneration ...
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Gata3 is required for the functional maturation of inner hair cells and their innervation in the mouse cochlea.
... regulates inner ear development from the formation of the embryonic otic ...major cochlear cell ...in hair cell maturation remains ...outer hair cells (OHCs) differentiate normally but ...
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Cochlear hair cell fate determination and differentiation in vitro
... the cells telomeres and thereby allows the cell to continue dividing, would be a better agent as it does not affect such regulatory systems as ...epithelial cells, the retinoblastoma (Rb)/pl6^*^'^^ ...
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Adenovirus Vectors Target Several Cell Subtypes of Mammalian Inner Ear In Vivo
... mouse inner ear cell subtypes for gene ...P4 inner ear, with different specificities and expression levels that are dependent on the type of adenoviral vectors and the age of ...The cochlear sensory ...
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Mechanotransduction is required for establishing and maintaining mature inner hair cells and regulating efferent innervation
... c Cochlear whole mount preparations from P10 Myo7a fl/fl (control, upper panel) and Myo7a fl/fl Myo15-cre + /- (lower panel) mice, immunostained for Myo7a (green) and for F-actin with phalloidin ...normal hair ...
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The retinoblastoma gene pathway regulates the postmitotic state of hair cells of the mouse inner ear
... to cochlear HCs, pRb was expressed in vestibular HCs ...supporting cells basally. In the mutants, HCs were intermixed with supporting cells in the middle layers and the basal part of the epithelium ...
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FM1-43 reveals membrane recycling in adult inner hair cells of the mammalian cochlea
... Tissue. Temporal bones were dissected from young adult guinea pigs (300 –350 gm) killed by rapid cervical dislocation according to United Kingdom animal care guidelines. Tissue was kept cool during dissection. Two ...
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Auditory Sparse Representation for Robust Speaker Recognition Based on Tensor Structure
... by cochlear feature based on frequency selectivity characteristics at basilar membrane and inner hair cells; then, low-dimension sparse features are extracted by NTPCA for robust speaker ...
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Original Article Spatiotemporal expression of Bmi1 in the developing mouse cochlea
... nonproliferating cells then dif- ferentiate within the sensory primordium to form a precise mosaic of hair cells and support- ing cells ...[1]. Hair cell differentiation starts ar- ound ...
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