Collagen Antibody-Induced Arthritis (CAIA)
Partial protection against collagen antibody induced arthritis in PARP 1 deficient mice
... the collagen antibody-induced arthritis model ...model, induced by passive immunization of mice with anti-type II collagen antibodies, allows the study of the effector phase of ...
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Trabecular bone loss in collagen antibody induced arthritis
... an arthritis model that can be used to study arthritis-induced osteoporosis in C57BL/6 ...mice. Collagen antibody-induced arthritis (CAIA) is a short commercially ...
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Treatment of a mouse model of collagen antibody induced arthritis with human adipose derived secretions
... of collagen antibody-induced arthritis (CAIA) in mice with secretions from SVF, SVF co-cultured with adipocytes, or a vehicle control via both intravenous (IV) and intramuscular (IM) ...
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Effect of M3 muscarinic acetylcholine receptor deficiency on collagen antibody induced arthritis
... clinical arthritis scores was observed between WT and M3R-deficient mice, but M3R defi- ciency led to a slightly higher incidence of disease induc- ...induce arthritis [27, 28]. When CAIA was ...
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Pathogenic roles of CXCL10 signaling through CXCR3 and TLR4 in macrophages and T cells: relevance for arthritis
... phage; CAIA: Collagen antibody-induced arthritis; CIA: Collagen-induced arthritis; CsA: Cyclosporin A; CTX: C-terminal telopeptide; CXCL10: C-X-C motif chemokine ...
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A 4 trifluoromethyl analogue of celecoxib inhibits arthritis by suppressing innate immune cell activation
... of arthritis, including CIA and type II collagen antibody-induced arthritis (CAIA), in contrast to the limited inhibitory effect of ...
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Transcription factor T bet regulates inflammatory arthritis through its function in dendritic cells
... inflammatory arthritis. We show that collagen antibody–induced arthritis (CAIA), a model of human RA, is a bipartite disease characterized by an early innate immune system ...
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Collagen triple helix repeat containing 1 is a new promigratory marker of arthritic pannus
... of collagen triple helix repeat containing 1 (CTHRC1) encoding gene was strongly associated with the severity of murine collagen antibody-induced arthritis (CAIA) ...When ...
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Collagen II antibody induced arthritis in Tg1278TNFko mice: optimization of a novel model to assess treatments targeting human TNFα in rheumatoid arthritis
... Cytokine measurements were made on serum samples and paws of CAIA animals. Paws were dissected above ankle at different time points post LPS challenge. One hind paw per animal was used for protein extraction. ...
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Type IX collagen deficiency enhances the binding of cartilage specific antibodies and arthritis severity
... to arthritis and hence only males were tested with a higher CII ...severe arthritis than the heterozygous or wild-type littermate controls (Table 1 and Figure ...severe arthritis than the wild ...the ...
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Estrogen regulates T helper 17 phenotype and localization in experimental autoimmune arthritis
... disease symptoms [3]. In a well-established experimental model of RA, collagen-induced arthritis (CIA), it has re- peatedly been shown that estrogen ameliorates disease de- velopment [4,5]. Regarding ...
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OX40 signaling is involved in the autoactivation of CD4+CD28− T cells and contributes to the pathogenesis of autoimmune arthritis
... Acute collagen-induced arthritis; APC: Antigen-presenting cell; CCK-8: Cell Counting Kit-8; CIA: Collagen-induced arthritis; C-CIA: Chronic collagen-induced ...
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Antibody mediated delivery of IL 10 inhibits the progression of established collagen induced arthritis
... radiolabelled antibody SIP(L19) (SIP, small immunoprotein) are currently in clinical development ...The antibody-mediated targeted delivery of cytokines is largely unexplored in arthritis and other ...
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Interleukin 21 signaling in B cells, but not in T cells, is indispensable for the development of collagen induced arthritis in mice
... Collagen-induced arthritis (CIA) is a widely used animal model of RA, and CIA can be induced by immunization of mice (or rats) with type II collagen ...anti-CII antibody (Ab) ...
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Monoclonal Anti-HMGB1 (High Mobility Group Box Chromosomal Protein 1) Antibody Protection in Two Experimental Arthritis Models
... including arthritis. HMGB1-blocking therapies in arthritis models alleviate dis- ease and confer significant protection against cartilage and bone ...anti-HMGB1 antibody (2G7, mouse IgG2b) to ame- ...
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A Rac1 inhibitory peptide suppresses antibody production and paw swelling in the murine collagen induced arthritis model of rheumatoid arthritis
... mechanisms. It is unlikely that Rac1 inhibition directly interferes with B-cell activation as Rac1 and Rac2 make critically redundant contributions to the transduction of B- cell receptor signals required for both ...
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Type II collagen antibody response is enriched in the synovial fluid of rheumatoid joints and directed to the same major epitopes as in collagen induced arthritis in primates and mice
... For antibody measure- ments, enzyme-linked immunosorbent assay plates (NUNC, Roskilde, Denmark) were coated with human CII peptides C1, U1, and J1 (5 μg/ml) at 4°C ...
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The involvement of C5a in the progression of experimental arthritis with Porphyromonas gingivalis infection in SKG mice
... protein antibody; AS: Arthritis score; BMC: Bone marrow mononuclear cell; C5aRA: C5aR antagonist; CIA: Collagen-induced arthritis; Ctrl: Control; ELISA: Enzyme-linked immunosorbent ...
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Induction of a B cell dependent chronic arthritis with glucose 6 phosphate isomerase
... (G6PI)-induced arthritis in different genetic backgrounds and major histocompatibility complex (MHC) ...Active arthritis, character- ized by redness and oedema, was scored over 90 days after ...for ...
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VARIOUS ANIMAL MODELS FOR PRECLINICAL TESTING OF ANTI INFLAMMATORY AGENTS
... Procedure: The mouse pleurisy was induced by a single intrapleural injection of 0.1 ml of carrageenan (1%). After 4 h the animals were killed with an overdose of ether, the thorax was opened and the pleural cavity ...
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