collagen-induced arthritis mice
Interleukin 10 attenuation of collagen induced arthritis is associated with suppression of interleukin 17 and retinoid related orphan receptor γt production in macrophages and repression of classically activated macrophages
... IL-17-transgenic mice are prone to develop CIA [22], whereas inhibition of IL-17 and its receptors with antibodies delay the development of arthritis and reduce its consequences ...
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Identification of collagen induced arthritis loci in aged multiparous female mice
... of arthritis commenced 25 days after the first ...The arthritis index was assigned to each mouse using the following criteria: 0 = no visible sign of arthritis, 1 = red- ness and swelling in a single ...
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Smoking and nicotine exposure delay development of collagen induced arthritis in mice
... autoimmune arthritis in mice. Extensive studies on transgenic mice expressing human susceptibility genes show that HLA- DQ and HLA-DR might be involved in susceptibility to or pro- tection from CIA ...
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Statins accelerate the onset of collagen type II induced arthritis in mice
... on arthritis induction using the latent variable model were similar to the results using the log-likelihood model, we have cho- sen to show the results of the latter ...
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Elevation of Bombina variegata peptide 8 in mice with collagen induced arthritis
... of arthritis peaked on approxi- mately day 30 ...CIA mice, but was below the detection limit in all control mice ...control mice sacrificed on day 35 (data not ...CIA mice with minimal ...
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Mast cell depletion in the preclinical phase of collagen induced arthritis reduces clinical outcome by lowering the inflammatory cytokine profile
... of arthritis and that their role is limited after the first appearance of clinical symptoms, at least in the CIA ...like collagen-specific IgE antibodies ...cell-depleted mice after stimulation with ...
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Brazilin isolated from Caesalpinia sappan L inhibits rheumatoid arthritis activity in a type II collagen induced arthritis mouse model
... three collagen-sensitized ...treated mice on day 42. The gross lesions in the foot of collagen-induced control group mice (Figure 4C-ii) was severe, but was lesser in MTX (Figure ...
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Monoclonal Anti-HMGB1 (High Mobility Group Box Chromosomal Protein 1) Antibody Protection in Two Experimental Arthritis Models
... including arthritis. HMGB1-blocking therapies in arthritis models alleviate dis- ease and confer significant protection against cartilage and bone ...of arthritis: collagen type ...
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Nature and specificity of the immune response to collagen in type II collagen induced arthritis in mice
... denatured collagen was noted. Antisera from nonarthritic mice immunized with denatured collagen primarily recognized covalent structural ...II collagen was essential for ...
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Original Article Individualized moderate aerobic exercise improves physical capacity and prevents weight loss in collagen-induced arthritis
... leading mice into exhaustion. The mice were set to run on an incline treadmill (slope, 5°) developed by ...injection, mice were placed on the treadmill for 10 min/day, for 5 days, at a speed of 10 ...
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THE ANTI ARTHRITIC POTENTIAL OF BARBADOS NUT JATROPHA CURCAS LINN (1753) LEAF EXTRACT IN BOVINE TYPE II COLLAGEN INDUCED ARTHRITIS IN MALE ALBINO MICE MUS MUSCULUS
... rheumatoid arthritis (RA), nowadays is very ...of arthritis as diagnosed by a doctor, one in 20 ...to arthritis, and by 2040, an estimated 78 million (26%) US adults ages 18 years or older are ...
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Abrogation of CC chemokine receptor 9 ameliorates collagen induced arthritis of mice
... clinical arthritis score in a dose-dependent manner (Figure ...the arthritis score was also signifi- cantly smaller by CCX8037 (10 mg/kg)-treated mice com- pared with vehicle-treated mice ...
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Autoantibody systems in rheumatoid arthritis: specificity, sensitivity and diagnostic value
... Autoantibodies directed to the p68 protein, recently iden- tified as heavy chain binding protein (BiP), occur in about 64% of RA patients and appear to be highly specific for the disease [35–37]. The reported specificity ...
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Dichloroacetate alleviates development of collagen II induced arthritis in female DBA/1 mice
... female mice were divided into three groups (10 mice per ...the mice were immunized by epicutaneous application of 150 μL of a mixture of ethanol acetone (2:1) containing 3% (vol/ vol) oxazolone (OXA) ...
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IgG glycoforms in arthritis
... The enzyme p-1,4-galactosyltransferase (GalTase) has, to date, been imphcated as the biggest cellular candidate in the control of IgG agalactosylation. GalTase transfers galactose to terminal oligosaccharide chains ...
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Pathogenic roles of CXCL10 signaling through CXCR3 and TLR4 in macrophages and T cells: relevance for arthritis
... of arthritis [19]. However, the sus- ceptibility for CIA is poor in mice of the C57BL/6 back- ground, the strain widely used for knockout ...contrast, collagen antibody-induced ...
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OX40 signaling is involved in the autoactivation of CD4+CD28− T cells and contributes to the pathogenesis of autoimmune arthritis
... Acute collagen-induced arthritis; APC: Antigen-presenting cell; CCK-8: Cell Counting Kit-8; CIA: Collagen-induced arthritis; C-CIA: Chronic collagen-induced ...
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Collagen induced arthritis is exacerbated in IL 10 deficient mice
... tor-deficient mice, and loss of the IFN-γ receptor turns mice normally resistant to CIA into an arthritis-susceptible strain ...IL-10-deficient mice is consistent with the disease-limiting ...
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Bystander suppression of collagen induced arthritis in mice fed ovalbumin
... of arthritis in mice fed ovalbumin (OVA). Mice were fed OVA or a standard diet for 7 ...the mice were immunized with BCII or BCII mixed with OVA, emulsified in Freund’s complete ...the ...
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A proinflammatory role for Fas in joints of mice with collagen induced arthritis
... to collagen in lpr/lpr mice was accompanied by significantly higher levels of IFN-γ secretion from these ...in mice and in humans ...lpr/lpr mice is caused by a lack of generation and priming ...
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