Colony stimulating factor - 1 receptor
Colony-stimulating factor 1 receptor (CSF1R) inhibitors in cancer therapy
... CSF1: Colony-stimulating factor 1; CSF1R: Colony-stimulating factor 1 receptor; CTLA4: Cytotoxic T-lymphocyte- associated protein 4; DC: Dendritic cells; ...
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Inhibition of colony-stimulating factor 1 receptor early in disease ameliorates motor deficits in SCA1 mice
... type 1 (SCA1) is a dominantly inherited neurodegenerative disorder characterized by progressive loss of motor coordination, cognitive impair- ments, and depression [32, ...of colony-stimulating ...
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Colony-stimulating factor 1 receptor blockade prevents fractionated whole-brain irradiation-induced memory deficits
... chemokine receptor expressed on cells of the myeloid cell lineage, and we have previously noted that CCR2 deficiency prevents radiation-induced hippocampal neuronal dysfunc- tion from a cellular and behavioral ...
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Colony-stimulating factor 1 receptor inhibition prevents disruption of the blood-retina barrier during chronic inflammation
... study, a prolonged systemic inflammatory stimulus with LPS led to increased vascular permeability, retinal swell- ing, and accumulation of sub-retinal fluid in Balb/c mice (Fig. 1 and Fig. 6q), indicating ...
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Mechanisms of amphibian macrophage development: characterization of the Xenopus laevis colony stimulating factor 1 receptor
... recognition receptor expression between tadpoles and adults, and a physiological necessity for more prominent adult monopoietic responses to in- flammatory, rather than viral ...the receptor (Chen et ...
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Inhibition of the colony-stimulating-factor-1 receptor affects the resistance of lung cancer cells to cisplatin
... this, receptor tyrosine kinases (RTK), among the most frequently modulated molecular hubs within chemoresistant tumors [31], may appear as ideal candidates to transduce stress-induced micro-environmental changes ...
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The Epstein-Barr Virus BARF1 Gene Encodes a Novel, Soluble Colony-Stimulating Factor-1 Receptor
... Epstein-Barr virus (EBV) is a ubiquitous human herpesvirus whose tissue tropism is typically restricted to B lymphocytes and epithelial cells. Although EBV infection is not usually life threatening, it is the causative ...
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Microglial Stimulation of Glioblastoma Invasion Involves Epidermal Growth Factor Receptor (EGFR) and Colony Stimulating Factor 1 Receptor (CSF-1R) Signaling
... Figure 4A). Furthermore, addition of Iressa to GL261 cells also had no effect on CSF-1 production, indicating that basal EGFR signaling in GL261 cells is not re- sponsible for this high constitutive CSF-1 ...
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Combination systemic therapies with immune checkpoint inhibitors in pancreatic cancer: overcoming resistance to single-agent checkpoint blockade
... antigen receptor; CCK: cholecystokinin; CSF1: colony-stimulating factor 1; CSF1R: colony-stimulating factor 1 receptor; CR: complete response; CTLA-4: ...
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Colony stimulating factor (CSF) 1 receptor blockade reduces inflammation in human and murine models of rheumatoid arthritis
... Immunohistochemical and digital imaging analysis Serial sections from six different TissueTek-embedded biopsy samples per patient were cut with a cryostat (5 μm), fixed with acetone, and endogenous peroxidase activity ...
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Genomic-guided precision therapy for soft tissue sarcoma
... 1R, colony- stimulating factor-1 receptor; DCR, disease control rate; DFSP, dermatofibrosarcoma protuberans; DOR, duration of response; EORTC, European Organisation for Research and ...
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Host microenvironment in breast cancer development Inflammatory and immune cells in tumour angiogenesis and arteriogenesis
... important factor responsible for increased macrophage infiltration in breast cancer is the macrophage colony-stimulating factor (CSF)-1; this is a haematopoietic growth factor ...
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Isoforms of the granulocyte-macrophage colony-stimulating factor receptor
... The haemopoietic system develops from mesenchymal tissue in at least two waves. The first, and most primitive, occurs in the yolk sac where blood islands and the first vascular cells develop in close proximity, ...
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Osteoclasts; culprits in inflammatory osteolysis
... one receptor, the tyrosine kinase ...its receptor in osteoclastogenesis is established by the fact that op/op mice, with a loss of function mutation in the Csf1 gene [38], and those deleted of c-Fms [66], ...
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A screen for peptide agonists of the G CSF receptor
... Granulocyte-colony stimulating factor (G-CSF) is one the most widely employed protein ...ligand: receptor stoichiome- try to its cytokine like receptor (G-CSF-R) which recruits in turn ...
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A study of the granulocyte-macrophage colony stimulating factor receptor (GM-CSFR) in leukaemia
... Acute myeloid leukaemia (AML) is a clonal disorder characterised by discordant proliferation and differentiation of primitive myeloid cells leading to excessive accumulation of malignant blast cells. AML incorporates a ...
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Increased granulocyte colony stimulating factor responsiveness but normal resting granulopoiesis in mice carrying a targeted granulocyte colony stimulating factor receptor mutation derived from a patient with severe congenital neutropenia
... Construction of the targeting vector. The molecular cloning and map- ping of the murine G-CSFR gene has been described previously (17). A PCR-based method was used to generate a C to T mutation within exon 17 at ...
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Expression and function of the granulocyte-macrophage colony-stimulating factor receptor durning myeloid differentiation
... affinity receptor enables the receptor chains and the associated JAK 2 tyrosine kinases to ...the receptor activate STAT 5 with equal effect when satu rated by high G M -C SF concentrations (10 ng/m ...
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Epigenetic dynamics of monocyte-to-macrophage differentiation
... CSF1: colony‑stimulating factor 1; CSF1R: CSF1 receptor; DMR: differentially methyl‑ ated region; ENCODE: Encyclopedia of DNA Elements; eRNA: enhancer RNA; FANTOM: Functional ANnoTation ...
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MicroRNAs and Their Role in Bone Remodeling and Pathogenesis
... macrophage colony-stimulating factor (MCSF), receptor activator for nuclear factor κB ligand (RANKL), tumour necrosis factor, interferon gamma, and interleukins (Ross et ...
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