Colorectal tumors
Expression of Survivin in Colorectal Tumors
... differentiated tumors, 24 (60%) samples were moderately differentiated tumors and ...Malignant colorectal tumors revealed positive expression of survivin in 8(16%) samples and negative in ...
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Right-sided rhabdoid colorectal tumors might be related to the Serrated Pathway
... of colorectal tumors with a rhabdoid phenotype have been reported ...These tumors are generally found in elderly patients at the proximal colon and show an aggressive behaviour characterized by an ...
7
Overexpression of Rad51C splice variants in colorectal tumors
... Bisulfite conversion of genomic DNA from colorectal tumors and cells was performed with EpiTect 96 Bisulfite kit (Qiagen, Hilden, Germany). The promoter region of Rad51C was retrieved from the Ensemble ...
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Epigenetic silencing of NTSR1 is associated with lateral and noninvasive growth of colorectal tumors
... detected colorectal tumors were observed at high magnification after staining with indigo carmine dye and ...noninvasive tumors was determined according to the Paris classification ...
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Detection of Human Epidermal Growth Factor Receptor 2 in Colorectal Tumors
... of colorectal cancer, genetic syndrome, lack of regular physical activity, low fruit and vegetable intake, a low-fiber and high-fat diet, overweight and obesity, alcohol consumption and tobacco use (5) ...
9
Subtypes of primary colorectal tumors correlate with response to targeted treatment in colorectal cell lines
... investigated four different datasets. First, we applied the subtype signatures obtained by iNMF using hierarchical clustering to a diverse, combined panel containing 67 CRC cell lines (AZCL, GSK, GSE8332). In general, ...
15
Leveraging Existing 16S rRNA Gene Surveys To Identify Reproducible Biomarkers in Individuals with Colorectal Tumors
... Fine-scale classification of sequences into OTUs did not improve our classification models. This was also tested in earlier efforts to use shotgun metagenomic data to classify individuals as having normal colons or ...
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Recombinant salmonella-based 4-1BBL vaccine enhances T cell immunity and inhibits the development of colorectal cancer in rats: in vivo effects of vaccine containing 4-1BBL
... and colorectal tissues than the other ...of colorectal tumors was observed in SL3261R ...murine tumors and par- tially inhibit tumor growth [22], it is possible that the attenuated Salmonella ...
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Synchronous Adenocarcinoma of Caecum and Sigmoid Colon: A Case Report
... primary colorectal tumors among 1669 ...synchronous colorectal carcinoma predominantly in males associated with a short post operative survival compared to cases with single ...
5
Transcriptional activation of integrin β6 during the epithelial mesenchymal transition defines a novel prognostic indicator of aggressive colon carcinoma
... Secondly, having a specific fibronectin receptor elicited as a consequence of the EMT also has selective advantages for tumor cells. The colonic epithelium resides upon a basement membrane, composed primarily of ...
10
Activation of an endogenous retrovirus-associated long non-coding RNA in human adenocarcinoma
... Results: We identified the tumor-specific expression of a novel lncRNA that we have named Endogenous retroViral-associated ADenocarcinoma RNA or ‘EVADR’ , by analyzing RNA-seq data derived from colorectal ...
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Over-expression of COX-2 mRNA in colorectal cancer
... in colorectal tumors, in comparison to nor- mal colorectal ...normal colorectal mucosa, however staining positivity in the tumor varied from 35 to 62% in sporadic colorectal cancers ...
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Decreased Overall Survival of Transanal vs. Transabdominal Resection of Early Rectal Cancer in Treatment Naïve Patients: A National Cancer Data Base Study
... of Colorectal Surgeons (ASCRS) and the National Comprehensive Cancer Network (NCCN) support the use of local resection for T1 tumors less than 3cm in size, accompanying less than 30% of the circumference of ...
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Refining EGFR-monoclonal antibody treatment in colorectal cancer
... KRAS can be mutated at several positions, 90 % of the activating KRAS mutations occur at codon 12 and 13[2]. Membrane association of the KRAS protein is crucial for its function as a switch in the signal transduction ...
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Partners in crime: the TGFβ and MAPK pathways in cancer progression
... predisposition due to inherited lesions in the TGFb pathway [54]. Additionally, mutations that inactivate the key signal components, including receptors and Smads, are frequently observed within the tumor. Loss of func- ...
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Overexpression of epidermal growth factor receptor as a prognostic factor in colorectal cancer on the basis of the Allred scoring system
... A total of 181 consecutive patients with CRC and who were treated at the Oncology Department of the Military Institute of the Heath Services, Warsaw between 2006 and 2010 were selected for the study. The inclusion ...
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Oxidized macrophage migration inhibitory factor is a potential new tissue marker and drug target in cancer
... of colorectal cancer [29], prostate cancer [30], ovarian cancer [20], neuroblastoma [31], pancreatic cancer [10], breast cancer [9], melanoma [22, 32] and lung cancer ...lung tumors [1, 3, 4, 7, ...
11
PINCH1 regulates Akt1 activation and enhances radioresistance by inhibiting PP1α
... Microarray data sets. For the analysis of PINCH expression data, Onco- mine (http://www.oncomine.org) was searched for studies comparing tumor with normal tissue containing probes for PINCH1 (selected studies are listed ...
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Inhibition of 11β–hydroxysteroid dehydrogenase type II selectively blocks the tumor COX 2 pathway and suppresses colon carcinogenesis in mice and humans
... chemoprevention of CRC. We found that expression of 11b–hydroxysteroid dehydrogenase type II (11bHSD2), which converts active glucocorticoids to inactive keto-forms, increased in human colonic and Apc +/min mouse ...
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Could Low Hdl Cholesterol Levels Be an Unvalued Predictor of Cancer Risk?: A Retrospective Case Study
... of tumors that the most pre- valent were those that have higher elevations of CEA traditionally related (colon, NSCLC, metastatic breast cancer…) [24] [25] ...
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