Complement membrane attack complex
Original Article Complement membrane attack complex is related with immune-mediated necrotizing myopathy
... of complement membrane attack complex (C5b-9) in the skel- etal muscle of patients with necrotizing myopathy (NM), and to investigate the relationship between C5b-9 and ...
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CryoEM reveals how the complement membrane attack complex ruptures lipid bilayers
... the membrane. Here we demon- strate that complement proteins within the C5b8 paddle rotate with respect to the nascent C9 oligomer, which in itself varies in curvature between the two observed MAC ...
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Inhibition of the complement membrane attack complex by the galactose specific adhesion of Entamoeba histolytica
... complement C5b-9 by screening for neutralizing monoclonal antibodies. A monoclonal antibody was identified that abrogated amebic resistance to C5b-9, and the mAb was shown to recognize the parasite's ...
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Complement membrane attack complex stimulates production of reactive oxygen metabolites by cultured rat mesangial cells
... which complement membrane attack complexes (MAC) that are deposited in the glomerular mesangium might be pathogenic, we stimulated rat glomerular mesangial cells grown in vitro with nascent MACs ...
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Structure of the poly C9 component of the complement membrane attack complex
... C5b678 complex, whereupon it self-assembles to form large, ring-shaped pores with a lumen over 100 Å in diameter embedded in the membrane of target cells 4 ...
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Paraneoplastic necrotizing myopathy associated with adenocarcinoma of the lung – a rare entity with atypical onset: a case report
... infiltrates, complement membrane attack complex deposition on endomysial capillaries, and moderate upregulation of major histocompatibility ...
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Inhibition of the Membrane Attack Complex by Dengue Virus NS1 through Interaction with Vitronectin and Terminal Complement Proteins
... terminal complement pathway. We first identi- fied the terminal complement regulator vitronectin (VN) as a novel DENV2 NS1 binding partner by using a yeast two-hybrid ...NS1-VN complex was also ...
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Complement fixation by pemphigus antibody V Assembly of the membrane attack complex on cultured human keratinocytes
... terminal complement components (C5, C6, C7, C8, and C9) and expression of C5b-9 neoantigens occur when PV IgG interacts with human keratinocyte (HuK) cell surface antigens in the presence of a source of ...
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Hepatitis C Virus Suppresses C9 Complement Synthesis and Impairs Membrane Attack Complex Function
... the membrane attack complex (MAC) components, only C5 and, in particular, C9 mRNA levels were significantly decreased in HCV-infected liver biopsy specimens ...the complement cascade was also ...
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A strategy to ensure safety of stem cell-derived retinal pigment epithelium cells
... to maintain the visual cycle; for example, metabolism and storage of retinoid, phagocytosis of rod outer segments, ab- sorption of scattered light, barrier activity and ion transport [6]. Degeneration of RPE in AMD ...
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Killing of human melanoma cells by the membrane attack complex of human complement as a function of its molecular composition
... The efficiency of the membrane attack complex (MAC) in killing M21 melanoma cells was determined varying the molar ratio of cell-bound C9:C8. It was found that C5b-8 produced functional channels as ...
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Complement induced glomerular epithelial cell injury Role of the membrane attack complex in rat membranous nephropathy
... induces complement (C)-mediated cell-independent ...the membrane attack complex (MAC), we determined the need for C8 in the pathogenesis of proteinuria in an autologous-phase model of ...
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Reduced membrane attack complex formation in umbilical cord blood during Eculizumab treatment of the mother: a case report
... that complement C9 deposition induced by activation of the classical path- way was almost completely abrogated in umbilical cord blood from the index newborn, whereas newborn controls showed a median of ...that ...
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Soluble membrane attack complex is diagnostic for intraventricular shunt infection in children
... Study Description. For this study, we quantitated ventricular CSF sMAC levels in the pediatric population at Children’s of Alabama, which included patients under evaluation for newly diagnosed hydrocephalus, shunt ...
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Development of the Cellular Immune System of Drosophila Requires the Membrane Attack Complex/Perforin-Like Protein Torso-Like
... EMBRANE attack complex/perforin-like (MACPF) pro- teins comprise a large, functionally diverse superfamily of molecules that include the mammalian immunity proteins complement component 9 (C9) and ...
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Membrane attack complex inhibitor CD59a protects against focal cerebral ischemia in mice
... of complement activation: in the postischemic brain tissue of the 30 min MCAO model complement activation may only result in sublytic MAC-concentrations, so that the MAC-mediated effects not directly result ...
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The complement system in glioblastoma multiforme
... human complement system is regarded to be a main effector arm of the innate immunity and com- prises around thirty soluble and membrane-associated pro- ...alternative complement pathway have been ...
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Systemic inhibition of the membrane attack complex impedes neuroinflammation in chronic relapsing experimental autoimmune encephalomyelitis
... of complement activation lead to cleavage of the C5 mol- ecule for generation of the anaphylatoxin C5a, and the opsonin ...the complement proteins C6 through C9, together form an oligomeric structure called ...
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Characterization of the complement sensitivity of paroxysmal nocturnal hemoglobinuria erythrocytes
... to complement-mediated lysis, we compared binding of C3 and constituents of the membrane attack complex to normal, PNH II, PNH III, and AET-treated cells after classical pathway activation by ...
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Review Article Targeting complement regulatory proteins in tumor immunotherapy
... The complement system is a vital part of the immune system, and its activation can eliminate malignant tumor ...cells. Complement regulatory proteins (CRPs) can regulate complement activation ...
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