Compound Kushen Injection

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A multicenter randomized controlled open label trial to assess the efficacy of compound kushen injection in combination with single agent chemotherapy in treatment of elderly patients with advanced non small cell lung cancer: study protocol for a randomiz

A multicenter randomized controlled open label trial to assess the efficacy of compound kushen injection in combination with single agent chemotherapy in treatment of elderly patients with advanced non small cell lung cancer: study protocol for a randomized controlled trial

Integrated traditional Chinese and Western medicine therapy have been the most distinctive methods in the treatment of malignant tumors in China. In the treatment of NSCLC, traditional Chinese medicine (TCM) in com- bination with chemotherapy can enhance the efficacy and reduce chemotherapy-induced toxicity [9, 10]. As a repre- sentative of TCM injection, compound kushen injection (CKI) has good effects on pain relief, ensuring hemostasis, anti-inflammatory activity, and anti-fibrosis [11]. CKI also has efficacy in the treatment of lung cancer [12]. When combined with chemotherapy, CKI enhances efficacy, reduces toxicity, and protects organs to improve the quality of life (QoL) and help patients complete chemotherapy [13, 14]. When considering elderly pa- tients’ characteristics, the side effects of traditional chemotherapy, and the unique function of CKI, treat- ment with CKI in combination with single-agent chemotherapy could be more reasonable and effective for the elderly with advanced lung cancer compared to standard chemotherapy.
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Review Article The efficacy of compound kushen injection in preventing and treating radiation-induced oral mucositis: a systematic review and meta-analysis

Review Article The efficacy of compound kushen injection in preventing and treating radiation-induced oral mucositis: a systematic review and meta-analysis

tries; (3) The treatment methods for oral muco- sitis when HNC patients receiving radiotherapy is incompletion consistently, like conventional therapy and intervening measures (including drugs or treatment courses), therefore, increas- ing the heterogeneity among studies to some extent; (4) Only a few studies designed follow- up visit after taking drugs, therefore, lack of aftereffect studies make this study limited in clinical promotion and application; (5) In all included studies, only one study used TCM syn- drome descriptions on HNC patients, so, TCM diagnosis and treatment descriptions were insufficient; (6) In addition, it is much to be regretted that there is no detailed comparison the length of hospital stay, the medical expens- es of the patients after using CKI in all study. In a word, based on the current research results, Compound Kushen Injection had more definite effect in treating radiation-induced oral mucositis, applicable to the clinical promotion and application. It also provides a new idea integrated Chinese and Western medicines in treating radioactive oral mucosa injury. The reporting of methodological issues was limited, more high-quality large samples, blind meth- ods and randomized controlled trials should be provided to evaluate further and verify the cura- tive effect of Compound Kushen Injection in preventing and treating oral mucosa injury resulted from radiotherapy or combined with chemotherapy on head-neck cancer patients. Conclusion
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Identification of candidate anti-cancer molecular mechanisms of Compound Kushen Injection using functional genomics

Identification of candidate anti-cancer molecular mechanisms of Compound Kushen Injection using functional genomics

Compound Kushen Injection (CKI) has been clinically used in China for over 15 years to treat various types of solid tumours. However, because such Traditional Chinese Medicine (TCM) preparations are complex mixtures of plant secondary metabolites, it is essential to explore their underlying molecular mechanisms in a systematic fashion. We have used the MCF-7 human breast cancer cell line as an initial in vitro model to identify CKI induced changes in gene expression. Cells were treated with CKI for 24 and 48 hours at two concentrations (1 and 2 mg/mL total alkaloids), and the effect of CKI on cell proliferation and apoptosis were measured using XTT and Annexin V/Propidium Iodide staining assays respectively. Transcriptome data of cells treated with CKI or 5-Fluorouracil (5-FU) for 24 and 48 hours were subsequently acquired using high-throughput Illumina RNA-seq technology. In this report we show that CKI inhibited MCF-7 cell proliferation and induced apoptosis in a dose-dependent fashion. We integrated and applied a series of transcriptome analysis methods, including gene differential expression analysis, pathway over-representation analysis, de novo identification of long non-coding RNAs (lncRNA) as well as co-expression network reconstruction, to identify candidate anti-cancer molecular mechanisms of CKI. Multiple pathways were perturbed and the cell cycle was identified as the potential primary target pathway of CKI in MCF-7 cells. CKI may also induce apoptosis in MCF-7 cells via a p53 independent mechanism. In addition, we identified novel lncRNAs and showed that many of them might be expressed as a response to CKI treatment.
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Compound Kushen Injection suppresses human breast cancer stem-like cells by down-regulating the canonical Wnt/β-catenin pathway

Compound Kushen Injection suppresses human breast cancer stem-like cells by down-regulating the canonical Wnt/β-catenin pathway

Compound Kushen Injection (CKI), commonly known as the Yanshu Injection, is extracted from two herbs Kushen (Radix Sophorae Flavescentis) and Baituling (Rhi- zoma smilacis Glabrae) with the primary components being oxymatrine and matrine [18]. The fingerprint of CKI is provided as additional file 1. CKI has been extensively used alone for cancer patients or in combination with che- motherapy or radiotherapy in Chinese clinical settings for many years. Previous clinical studies have shown that CKI attenuates side effects of chemotherapy and radiotherapy by improving the quality of life, regulating the immune function of cancer patients and synergizes the therapeutic effects of chemotherapy and radiotherapy as well [19,20]. It has been demonstrated that CKI suppresses tumor cell growth by inducing apoptosis [21] and inhibits the migra- tion, invasion and adhesion capacity by down-regulating the expression of CD44 v6 protein [22]. However, the
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Compound kushen injection suppresses human acute myeloid leukaemia by regulating the Prdxs/ROS/Trx1 signalling pathway

Compound kushen injection suppresses human acute myeloid leukaemia by regulating the Prdxs/ROS/Trx1 signalling pathway

efficiency and low toxicity antioxidants will effectively improve survival in AML patients [7]. We have ex- plored and screened a series of antioxidants and found that the compound kushen injection (CKI) could de- crease intracellular ROS levels and inhibit AML cell proliferation (Figs. 1 and 2). CKI is a compound con- taining oxymatrine and matrine, which are mainly used to stop in cancer pain and bleeding and had no obvi- ous toxic side effects. The component of CKI is shown in Additional file 1: Figure S1. Studies have shown that CKI has antioxidant and immune activities and inhibits the occurrence of gastric cancer by enhancing immune activity [8]. In vitro and in vivo studies have confirmed that CKI inhibits human breast cancer stem cell prolif- eration by down-regulating the Wnt/ β -catenin pathway [9]. Additionally, CKI reduces tumour growth and alleviates cancer pain by blocking the TRPVI signalling pathway [10].
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Original Article Clinic value of compound kushen injection combined with chemotherapy in breast cancer: a systematic review and meta-analysis

Original Article Clinic value of compound kushen injection combined with chemotherapy in breast cancer: a systematic review and meta-analysis

Abstract: Purpose: To evaluate the efficacy and safety of compound kushen injection (CKI) combined with che- motherapy in the treatment of breast cancer. Methods: Electronic databases, including PubMed (n=2), EMBASE (n=2), The Cochrane Library (n=1), Web of Science (n=14), CNKI (n=56), VIP (n=34), CBM (n=41) and Wan Fang (n=45) were searched for relevant original articles. Random or fixed effect models were adopted to estimate the summary odds ratio (OR) and 95% confidence interval (CI). Results: Thirty-one trials including 2234 cases were identified for meta-analysis with RevMan5.3. The meta-analysis showed that there were significant differences in the tumor response (OR=2.07, 95% CI [1.61, 2.67], P<0.00001), KPS score (OR=2.63, 95% CI [1.97, 3.52]; P<0.00001), CD4 + cells (MD=10.21, 95% CI [8.70, 11.71]; P<0.00001), CD8 + cells (MD=12.72, 95% CI [10.45,
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Variable cavity volume tooling for high performance resin infusion moulding

Variable cavity volume tooling for high performance resin infusion moulding

The use of ‘active’ or articulated cavities in closed- mould RTM has been investigated as a means of apply- ing a mechanical pressure to the resin so as to induce a local high-pressure gradient at positions remote from the injection port. Ikegawa et al. [10] employed a moveable mould half that was lowered down onto the fibre after injection to provide a compressive squeezing force onto the resin, thus increasing infu- sion rates. The primary aim of the research, however, was to achieve lower void fractions than previously obtained using RTM, which it was successful in deliv- ering. It was concluded that the fabric permeability was increased by higher resin flowrates, thus prevent- ing the formation of voids through air entrapment. Despite this, however, a minimum void volume frac- tion of approximately 3 per cent was only achievable. Choi and Dharan [11] took a similar but significantly more complex approach, using a set of adjacent move- able core blocks. Resin compression and infusion was delivered through sequential raising and lowering of the blocks to transfer the resin load longitudinally through the fibre. This research demonstrated sig- nificant resin infusion rate increases over standard RTM but no results were presented for the resulting mechanical properties of the component so formed. Furthermore, the mould tool was very complex and would be extremely expensive to manufacture, and would be likely not to be economically feasible for the manufacture of low-cost UAVs.
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Differences in anatomical connections across distinct areas in the rodent prefrontal cortex

Differences in anatomical connections across distinct areas in the rodent prefrontal cortex

Our results have shown that the FG injections produced retrograde labelling and our FR injections primarily produced anterograde labelling. For FR labelling we base this judgement on the majority of labelling not co-localising with alpha-tubulin (a cytosplasmic marker). We used relatively large tracer injections (of 100nl FG and 100nl FR) because this produced a consistent and repeatable injection volume that ensured significant labelling within the projection sites (i.e. connected regions). We cannot rule out some spread to fibers of passage. The size of the tracer injections inevitably also meant that tracer was not usually confined to just one sub-region of PFC, in the case of PL injections there was also some spread into secondary motor cortex. In addition, our comparison of single injections revealed that these were not identical in terms of mean location of projection label (figures 9-12) however an analysis of their distributions showed a very similar overall distribution (figures 5- 8). Here we aimed to look at how connectional architecture changes at anterior and posterior PFC levels, however the changing shape and architecture of PFC in the A-P axis provided limitations to the study (see below for a detailed discussion). It is worth also pointing out that our terms of ‘anterior’ and ‘posterior’ PFC are relative, as there are significant anterior and posterior regions beyond the levels we have studied (approximately 1mm anterior and approximately 2mm posterior). Therefore the levels of PFC studied in this paper should both be considered to be central regions.
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Evaluation of the impact of viscosity, injection volume, and injection flow rate on subcutaneous injection tolerance

Evaluation of the impact of viscosity, injection volume, and injection flow rate on subcutaneous injection tolerance

The injected volume ratio significantly decreased with increasing fluid viscosity. Injection system occlusions were recorded in 15% (22) of cases resulting in difficulties to complete the injection for the last 20% of the fluid. This strongly indicates that the injection delivery system required for fast and large volumes of viscous injections needs to be specifically designed, independent of the subject’s tolerance. Indeed, this problem was not identified during the prestudy pump selection tests. As it was essential for the study design that injections were performed with the same pump, it was not possible to correct the issue when it was identified. It is difficult to evaluate whether this phenomenon impacts the study conclusion, indicating that high-viscosity fluids are less painful on injection. On one hand, the volume actually deliv- ered was lower with viscous fluid injections, but on the other hand, the injected volume did not have an effect on injection pain. Moreover, the complementary analyses conducted on the 122 complete injections were found to confirm the results: viscosity effect remained almost significant (P = 0.08).
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In-depth Analysis of Mass SQL injection, Blind SQL injection Tool ver2.0 [c0ck3dpist0l].pdf

In-depth Analysis of Mass SQL injection, Blind SQL injection Tool ver2.0 [c0ck3dpist0l].pdf

그래서 패턴 매칭의 경우 수만가지가 나올수 있다는 것을 명심하고 변수와 데이터베이스 컬럼을 정의 하고 Query 의 결과 로 반환되는 변수의 형 (type) 을 정의 하고 문자열의 데이터 길이를 제한하고 적절한 오류처리가 필요하다 . 어떤 공격이나 그러하겠지만 sql injection 공격은 짧은 시간에 많은 변화를 이룩했던 것 같습니다 그런만큼 많은 정보를 읽고 공부하면 . 서 대응하는 방법의 자세로 임해야 될 것 같습니다 많은 도움주신 분들게 감사합니다 . .
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A “Mold Filling” Model from Viscosity Measurements in a Strengthened Injection Molded Reduced Glass Fiber Length Polyester Bulk Molding Compound

A “Mold Filling” Model from Viscosity Measurements in a Strengthened Injection Molded Reduced Glass Fiber Length Polyester Bulk Molding Compound

thickness (th). Moreover, the Mooney-Rabinowitsch cal- culation was found to be a decent predictor for shear rates across specimen thickness and at mold walls measured from the mapping. This was without buying new equip- ment, using the existing injection molding machine to save cost.

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Impact of Pharmaceutical Care on Self Administration of Outpatient Low Molecular Weight Heparin Therapy

Impact of Pharmaceutical Care on Self Administration of Outpatient Low Molecular Weight Heparin Therapy

For prophylaxis and treatment of venous thromboembolisms (VTE), the use of low-molecular-weight hepa- rins (LMWH) is well established [1]. Therapies are often initiated during a hospital stay or at discharge, fol- lowed by daily s.c. self-injections for a period of time varying from days to weeks or even longer. Because after discharge most patients visit a community pharmacy to fill their prescription, pharmacists play an important role in the continuity of care by assuring correct drug use over the prescribed time [2] [3]. The community pharma- cist’s conventional role of preparing and dispensing drugs is changing, and the provision of new pharmaceutical services is needed [3]. The influence of pharmaceutical care on asthma, dyslipidemia, hypertension, and diabetes has been investigated [4]-[10], but knowledge of the effectiveness of community-pharmacy-based interventions on problems in self-administering s.c. injection therapies is lacking.
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Original Article Treatment of psoriasis by compound glycyrrhizin injection and its effects on peripheral blood Th17 cell proportion and IL-22 concentration

Original Article Treatment of psoriasis by compound glycyrrhizin injection and its effects on peripheral blood Th17 cell proportion and IL-22 concentration

yrrhizin is extracted from licorice, which is a tra- ditional Chinese medicine. Compound glycyrrhi- zin has several therapeutic functions, including anti-inflammatory, anti-allergies and suppress- ing the virus activity, protecting the liver cells, and immunomodulatory effects [7]. The previ- ous studies showed that the compound glycyr- rhizin can achieve immunomodulation by reduc- ing capillary permeability, increasing INF-γ, activating NK cells and T cells and inhibiting complement response [8-10].

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Automatic Compound Processing: Compound Splitting and Semantic Analysis for Afrikaans and Dutch

Automatic Compound Processing: Compound Splitting and Semantic Analysis for Afrikaans and Dutch

In the course of the project, several datasets were developed. For both Dutch and Afrikaans there were two annotation rounds for NN compounds and one smaller annotation experiment for XN compounds. An overview of the semantics data can be found in Table 2, including the average Cohen’s Kappa scores. The Dutch NN compounds were taken from the same raw compound list of 71,274 compounds de- scribed in section 3.2 above. Subsequent annotations were performed by students in linguistics at the University of Antwerp, all native speakers of Dutch. The first dataset was annotated by one student, and a subset of 500 compounds by one of the authors in order to calculate inter-annotator agreement. The second round of data was annotated by three students, with the data divided between them in such a way that we had two annotations for each compound. For the XN compound dataset, only 600 compounds were annotated.
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Problems in Identification of Methylenediony and Methoxy Amphetamines

Problems in Identification of Methylenediony and Methoxy Amphetamines

Spectrofluorescence spectra in methanol left Compound A, right Compound B.... Mass spectra top Compound A, bottom Cornpound B..[r]

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Synthesis, Characterization of Some Novel 1, 4- Benzoxazine- 3- One Derivatives Starting From O-Amino Phenol and Study Their Biological Activity

Synthesis, Characterization of Some Novel 1, 4- Benzoxazine- 3- One Derivatives Starting From O-Amino Phenol and Study Their Biological Activity

Potassium hydroxide (1.68 g, 0.03 mol) was dissolved in absolute ethanol (25 ml), then cooled in ice bath, acid hydrazide compound (3) (2.21g, 0.01 mol) was added with stirring. To above mixture carbon disulfide (0.05 mol, 4 ml) was added drop wise with continuous stirring. The reaction mixture was agitated continuously for 18 h at room temperature, then cold ethanol (20ml) was added to this solution. The solid product (ST) was filtered, washed with dry ether and dried. The potassium salt thus obtained was used in the next step without further purification.
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(3 Methyl­benzo­nitrile 1κN) cis tetra­kis(μ N phenyl­acetamidato) 1:2κ4N:O;1:2κ4O:N dirhodium(II)(Rh—Rh)

(3 Methyl­benzo­nitrile 1κN) cis tetra­kis(μ N phenyl­acetamidato) 1:2κ4N:O;1:2κ4O:N dirhodium(II)(Rh—Rh)

The axial rhodium-nitrogen-carbon bond angle for 1 , 162.8 (5)° (Fig.1) is distinctly non-linear which is different from those found in compound 2 (178.5 (5)° and 169.3 (5)°), and compound 3 (180°; imposed by space group symmetry), but similar to those found in compound 4 (167.14 (15)°) and compound 5 (166.4 (4)°). The axial carbon–nitrogen bond length in 1 is 1.154 (7) Å which is comparable to corresponding distances found in 2 (1.135 (8) Å and 1.145 (8) Å) as well as 4 (1.135 (3) Å) and 5 (1.135 (3) Å) and slightly longer than 3 (1.106 (6) Å). The [Rh 2 [N(C 6 H 5 )COCH 3 ) 4 ] portion
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Reportage as Compound Suggestion

Reportage as Compound Suggestion

This pattern of suggestion contravenes the notion that order of mention signifies order of occurrence. Whether these countervailing patterns of suggestion create confusion amon[r]

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Allorecognition in compound ascidians

Allorecognition in compound ascidians

Int J De\' Hiol 38 237 247 (1994) 237 Review Allorecognition in compound ascidians YASUNORI SAITO', EUICHI HIROSE' and HIROSHI WATANABE' Shimada Marine Research Center, University of Tsukuba, Shimada,[.]

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Compound Wiretap Channels

Compound Wiretap Channels

We further study the parallel Gaussian compound wire- tap channel, in which the channels to each receiver and to each eavesdropper are parallel Gaussian channels with multiple Gaussian subchannels. Channels of this type arise, for example, in wideband wireless communication systems such as frequency division multiplexing (FDM) systems in which transmission takes place over a number of frequency bands, and the eavesdroppers can tune their receivers to access some of these frequency bands. Understanding this channel is also important for studying the compound time- varying fading wiretap channels, as the parallel channel serves as a general model for the fading channel.
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