Control of the initiation of translation
Photosynthetic Control of Arabidopsis Leaf Cytoplasmic Translation Initiation by Protein Phosphorylation
... of translation initiation in plants is still rather incomplete and further work is needed to disentangle the specific role of individual eIFs and their associated phosphoryla- ...translational ...
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Post transcriptional control by bacteriophage T4: mRNA decay and inhibition of translation initiation
... post-transcriptional control, including the genetic code, mRNA, and tRNA; the very foundations of molecular ...post-transcriptional control are also summarized. These include: RNA structure at ...
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The Biological Roles of Translation Initiation Factor 3b
... to control eIF3b-mediated translation for tumor treatment, particularly via the phosphorylation of the eIF3 complex at seven phosphorylation sites (Ser-83, Ser-85, Ser-119, Ser-125, Ser-152, Ser-154, and ...
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On the functions of the h subunit of eukaryotic initiation factor 3 in late stages of translation initiation
... neither do we rule out that eIF3h may play additional roles in translation initiation or beyond. It is noteworthy, however, that long uORFs such as those found to confer eIF3h depend- ence in AtbZip11 ...
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Small-molecule targeting of translation initiation for cancer therapy
... Translation initiation plays a critical role in the regulation of cell growth and ...inhibiting translation initiation through induction of eIF2α phosphorylation by small-molecular-weight ...
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Tumor suppression by small molecule inhibitors of translation initiation
... inoculated with MCF-7 (HTB-22, PI3Kα mutant) or CRL-1500 (ZR75-1, PTEN deficient) human breast cancer cells into the 4 th inguinal gland. Tumors were allowed to grow 150 mm 3 size, animals were randomly distributed to ...
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Dengue Virus Utilizes a Novel Strategy for Translation Initiation When Cap-Dependent Translation Is Inhibited
... dependent translation, siRNA-mediated gene silencing was em- ployed to suppress expression of the prototypical form of mam- malian eIF4E, eIF4E-1 ...a control plasmid containing the eIF4E-1 sequence in ...
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Modulation of Translation Initiation Efficiency in Classical Swine Fever Virus
... four Watson-Crick base pairs in the opposite configuration within stem 2 of domain IIIf. Rescue of mutant viruses with mutated IRES elements. To evaluate the effect of the various IRES mutations on virus replica- tion ...
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Minimum Requirements for the Function of Eukaryotic Translation Initiation Factor 2
... dependent nuclear tRNA export pathway in yeast. Genes Dev. Hovanessian, 1993 Tumor suppressor function of the inter- 14: 830–840. feron-induced double-stranded RNA-activated protein kinase. Hannig, E. M., and A. G. ...
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Author Manuscript. Title: Hijacking Translation Initiation for Synthetic Biology
... for initiation at AUG codons resulting in a mixture of products containing both Met and the ncAA at the initiating ...precise control of the concentration of ncAA and canonical amino acids, can limit ...
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The Eukaryotic Translation Initiation Factor 4GI Is Cleaved by Different Retroviral Proteases
... in control experiments this value ...the control of the IRES element from encephalomyocarditis virus (EMC-Luc) or capped luciferase mRNAs with the 5⬘ noncoding region from MoMLV (5⬘NCMo-Luc) and 2 g of ...
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Deciphering the Translation Initiation Factor 5A Modification Pathway in Halophilic Archaea.
... Those differences could explain why GC7 and spermidine do not bind Hfx. volcanii DHS. This study opens the question of DHS in halophile organisms. As a further control, the in vitro DHS activity of another member ...
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Translation initiation factor eIF3 promotes programmed stop codon readthrough.
... positive control, was exchanged for UGA-AUA-AAU or UGA-AAC-GGU, representing the hexanucleotides taken from the SUP45 and ADE1 termi- nation sequences, ...negative control because of their highly efficient ...
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Therapeutic suppression of translation initiation modulates chemosensitivity in a mouse lymphoma model
... translational control. As eukaryotic translation initiation factor 4E (eIF4E) cooper- ates with c-Myc during lymphomagenesis, induces drug resistance, and is a genetic modifier of the rapamycin ...
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Ctk1 Function Is Necessary for Full Translation Initiation Activity in Saccharomyces cerevisiae
... Impaired translation in Ctk1-depleted cells is not due to an overall stress defect as in ⌬ ctk1 ...of translation initiation ...of translation initiation by deletion of Ctk1, the ...
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Activation of AP-1-Dependent Transcription by a Truncated Translation Initiation Factor
... cells were harvested every 6 min from the time of temperature shift and were processed for Northern blotting. The blots were probed to detect SPBC409.13 mRNA. Intensities of bands corresponding to ma- ture SPBC409.13 ...
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Regulation of translation initiation at the Poliovirus IRES
... of initiation complexes on IRESs bound to Streptavidin ...its translation (Belsham & Sonenberg ...to translation initiation without ...the initiation complex, I allowed formation of 48S ...
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Translation initiation: structures, mechanisms and evolution
... of translation initiation and its regulation The process of initiation is schematically presented in ...that translation initiation has little in common with the simple enzymic ...
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Global mRNA selection mechanisms for translation initiation
... the translation repressors Caf20p and ...where translation is highly active and initiated robustly via the closed loop ...that translation initiation via the closed loop complex could be more ...
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Interaction of eukaryotic initiation factor eIF-4B with a picornavirus internal translation initiation site.
... KARSTEN MEYER, ANKE PETERSEN, MICHAEL NIEPMANN, AND EWALD BECK* Biochemisches Institut am Klinikum der Justus-Liebig-Universita ¨t Giessen, Giessen, Germany Received 21 November 1994/Accepted 25 January 1995 We studied ...
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