COX-2
Over-expression of COX-2 mRNA in colorectal cancer
... of COX-2 levels in laboratory animals subjected to entero-esophageal reflux, less ani- mals developed esophageal adenocarcinoma ...of COX-2, such as various non-steroidal anti- inflammatory ...
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Interaction between COX-1 and COX-2 increases susceptibility to ischemic stroke in a Chinese population
... We had got some statistically significant positive re- sults from the single gene polymorphism research of COX-1 and COX-2 gene. But these results were not en- tirely consistent with existing ...
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Allelic variation in the canine Cox-2 promoter causes hypermethylation of the canine Cox-2 promoter in clinical cases of renal dysplasia
... This study shows that novel allelic variants in the CpG island of the Cox-2 promoter have aberrant methylation of the Cox-2 promoter only in clinical cases of RD. The wild-type alleles are ...
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Discovering COX-2 Inhibitors from Flavonoids and Diterpenoids
... Selective COX-2 inhibitors, e.g. coxib drugs such as rofecoxib (Vioxx ® ) and valdecoxib (Bextra ® ),were withdrawn from the market in 2004 and 2005, respectively, because of their effects on increased risk ...
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COX-2 expression in papillary thyroid carcinoma (PTC) in cytological material obtained by fine needle aspiration biopsy (FNAB)
... of COX-2 gene was assessed, using the ABI PRISM 7500 SDS Software (ABI PRISM 7500 Sequence Detection System, Applied Biosystems), according to the manufacturer ’ s ...for COX-2 gene were run ...
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Selective inhibition of cyclooxygenase (COX) 2 reverses inflammation and expression of COX 2 and interleukin 6 in rat adjuvant arthritis
... selective COX-2 inhibitor to block PG production (23) and acute tissue inflammation (27) in vivo at dosages that do not affect stomach PG production, suggesting that COX-2 inhibitors may ...
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Biological effects of selective COX-2 inhibitor NS398 on human glioblastoma cell lines
... Taking into account previous reports which showed that anti-glioma effects of some clinical and experimen- tal approaches are associated with upregulation of the autophagic pathway [39, 40], it would be of interest to ...
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Expressions of COX-2 and VEGF-C in gastric cancer: correlations with lymphangiogenesis and prognostic implications
... with COX-2 antibodies (monoclonal rabbit anti-human, 1:100, Goldenbridge Biotechnology Co, Ltd, Beijing, China) and VEGF-C antibodies (poly- clonal rabbit anti-human, 1:100, Goldenbridge Biotech- nology ...
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Expression of NOS–2, COX–2 and Th1/Th2 cytokines in migraine
... on COX-2 activation: in fact COX-2 expression was decreased with respect to the baseline ...and COX-2 and their metabolites is, in other experimental systems, well ...
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Should selective Cox-2 inhibitors be used more?
... The unanticipated outcomes of several clinical studies raised a number of issues regarding the clinical efficacy and overall safety of selective coxibs. The important issue that has to be resolved is that the ...
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Etoricoxib as a Probe of COX-2 Mechanisms in Learning and Memory
... conditions, COX-2 inhibitors inhibit learning and memory by dampening NMDA signaling and thus inhibiting the processes of learning and ...increases COX-2 expression and subsequent ...
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YAP transcriptionally regulates COX-2 expression and GCCSysm-4 (G-4), a dual YAP/COX-2 inhibitor, overcomes drug resistance in colorectal cancer
... and COX-2 were synergistic in apoptosis of these cells, we assessed the effects of shRNA targeting YAP and COX-2 on apoptosis sensitivity in HCT8 and 15/Tax ...or COX-2 ...
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New functions for Cox 2 in health and disease: Report of “The Third International Workshop on Cox 2”, Ka’upulehu, Kona, Hawaii, USA, 30 August to 2 September 1999
... for Cox-2 in the gut was proposed by William F Stenson (Washington University School of Medicine, St Louis, MO, ...the Cox-2 selective cele- coxib were administered concomitantly with the ...
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COX 2 protects against thrombosis of the retinal vasculature in a mouse model of proliferative retinopathy
... of COX-2 pharmacologi- cally is difficult, and few agents are capable of achieving more than 90% inhibition of COX-2 without concomitant inhibi- tion of COX-1 ...of COX-2 ...
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Development and Evaluation of Polyherbal Tablet Formulation with Potent Anti Inflammatory and COX 2 Inhibitory Activity
... of COX-2 ...inhibiting COX-2 ...of COX-1 inhibitors, herbs selectively inhibiting COX-2 enzyme need to be ...specific COX-2 inhibitory activity in order to ...
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Original Article Association between COX-2 polymorphisms and non-small cell lung cancer susceptibility
... between COX-2 polymorphisms and non-small cell lung cancer (NSCLC) ...analyze COX-2 polymorphisms of two ...detecting COX-2 rs689466 and rs5275 polymorphisms, the distribution ...
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QSAR Study of 4-Benzylideneamino-Benzenesulfonamides and 4-Phenyliminomethyl-Benzenesulfonamides as Selective Cox-1 and Cox-2 Inhibitors
... of COX enzyme as a highly suitable target in anti-inflammatory ...Although COX-2 is concerned to be the main isoenzyme related to inflammation, most NSAIDs in the market today block both forms of ...
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Exacerbation of inflammation associated colonic injury in rat through inhibition of cyclooxygenase 2
... of COX-1 activity in vivo are not yet available, so it is difficult to determine the precise contri- bution of COX-1 ...vs. COX-2 to prostaglandin synthesis by a tis- ...from ...
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Original Article Anti-tumor effect and mechanism of cyclooxygenase-2 inhibitor through matrix metalloproteinase 14 pathway in PANC-1 cells
... of COX-2 and MMP-14 was assessed by ...of COX-2 and ...with COX-2 expression. Conclusions: COX-2 inhibitor celecoxib can inhibit the proliferation, invasion and ...
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BISPHENOL A ENHANCES GROWTH OF Hep G2 CANCER CELLS BY UPREGULATING EXPRESSION OF PRO – INFLAMMATORY AND PRO – ANGIOGENESIS PROTEINS
... Akt, COX-2, HIF-1α and VEGF, which are generally found to aid cancer ...a COX-2 inhibitor, reduced the cell viability in HepG2 cells and treatment with Meloxicam was found to down regulate the ...
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