CQ and 8-HQ Induce Mitochondrial Dysfunction
HAART drugs induce oxidative stress and mitochondrial dysfunction in blood-brain barrier
... A noticeable decrease in trans-endothelial electrical resistance (TEER) and an increase in dextran permeability across the monolayer of endothelial cells provide evidence that HAART drugs induce gaps between ...
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Tau oligomers impair memory and induce synaptic and mitochondrial dysfunction in wild-type mice
... and mitochondrial impairment is prevalent ...AD, mitochondrial abnormalities occur early in the pathogenic process and likely play a significant role in disease ...the mitochondrial marker porin, ...
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Mitochondrial dysfunction in Parkinson’s disease
... that dysfunction of mitochondria may play key roles in DA neuronal ...to mitochondrial dysfunction and PD ...inhibit mitochondrial complex I provides direct evidence linking ...
8
Mitochondrial dysfunction in human pathologies
... of mitochondrial function and impaired oxidative phosphorylation, with severe deficiencies of mitochondrial respiratory chain complexes I and II/III and aconitase activities, have been observed in ...
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<p>Zinc Oxide Nanoparticles Induce Mitochondrial Biogenesis Impairment and Cardiac Dysfunction in Human iPSC-Derived Cardiomyocytes</p>
... Electrophysiology has been widely used in the evalua- tion of cardiac function both in in vitro and in in vivo tests. MEA is a label-free, non-invasive and cost-effective mea- surement at the high-throughput scale and ...
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Polycystic ovary syndrome and mitochondrial dysfunction
... abnormal mitochondrial-related gene in the animal is knocked down, and whether or not the animals exhibited PCOS phenotypes is ...the mitochondrial genetic abnormalities cause ...can induce the onset ...
15
Mitochondrial Dysfunction in Stem Cell Aging
... 26 Recent data suggest that we age, in part, because our self- renewing stem cells grow old as a result of heritable intrinsic events, such as DNA damage, as well as extrinsic forces, such as changes in their supporting ...
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Mitochondrial Dysfunction in Stem Cell Aging
... 26 Recent data suggest that we age, in part, because our self- renewing stem cells grow old as a result of heritable intrinsic events, such as DNA damage, as well as extrinsic forces, such as changes in their supporting ...
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Effects of mitochondrial dysfunction on the immunological properties of microglia
... to mitochondrial dysfunction [13], and an impairment of mitochondrial activity has been observed in cells and tissues isolated from patients with neurode- generative ...the mitochondrial ...
10
Implications of mitochondrial dynamics on neurodegeneration and on hypothalamic dysfunction
... and mitochondrial fragmentation have been detected by the ß-amyloid protein (Aβ), a mediator of Alzheimer’s disease (AD) ( Head et ...Ubc9 induce mitochondrial fission by stabilizing Drp1 ( Harder et ...
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The genetic architecture of mitochondrial dysfunction in Parkinson's Disease
... Autosomal dominantly inherited mutations in the SNCA gene encoding alpha-synuclein (PARK1/PARK4; OMIM: 168,601, 605,543) were the first identified genetic cause for PD (Polymeropoulos et al. 1997 ; Krüger et al. 1998 ). ...
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Mechanical ventilation interacts with endotoxemia to induce extrapulmonary organ dysfunction
... organ dysfunction, in the absence of overt lung ...drial dysfunction and is due to impairment of fatty acid β- oxidation ...[19-21]. Mitochondrial injury and resulting microve- sicular steatosis can ...
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Mitochondrial disease and endocrine dysfunction
... trafficking. Mitochondrial diseases are multisystem disorders of oxidative phosphorylation that are characterised by enormous clinical, biochemical and genetic ...Currently mitochondrial disease has been ...
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Mitochondrial Dysfunction and Alzheimer’s Disease
... brain mitochondrial function showed some TCA cycle changes that lead to markedly impaired bioenergetics and impaired ability to both metabolize pyruvate and respire properly from the NADH generated by pyruvate ...
6
Neuronal degeneration and mitochondrial dysfunction
... The failure to detect true cell death in muscle from patients with mitochondrial disease tells us little about neuronal cell death in these patients. It does, however, send a cautionary message regarding a ...
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Mitochondrial dysfunction in the pathogenesis of neurodegeneration
... The molecular mechanisms behind the formation of deletions are not yet known but possibilities include slipped mispairing between distant repeats during replication, breakage and ligation of replication intermediates, ...
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Mitochondrial dysfunction in diabetic cardiomyopathy
... optimal mitochondrial metabolism to meet its high-energy ...and mitochondrial function is compromised, which we propose results in contractile dysfunction and thus contributes to diabetic ...to ...
9
Investigating the pathogenesis of mitochondrial dysfunction in mitochondrial and other myopathies
... Given this and previous work it is concluded that mtDNA deletions likely arise due to the combined effect of sarcopenia and disease pathogenesis. The reason for this conclusion is that the two most severely affected ...
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Mitochondrial Dysfunction in Lyssavirus-Induced Apoptosis
... the mitochondrial ge- netic code and within the context of the two-hybrid assay, the CcO1 insert encodes a very small fragment corresponding to aa 104 to 125 of ...
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The role of mitochondrial dysfunction in acute pancreatitis
... of mitochondrial Ca 2+ , during these events, modest generation of ROS was observed and experimentally confirmed to be Ca 2+ -dependent ROS which was reliant upon the functional electron transport ...
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