cyclic nucleotide gated channel
Becirovic, Elvir (2010): Role of the CNGB1a Subunit of the Rod Cyclic Nucleotide-Gated Channel in Channel Gating and Pathogenesis of Retinitis Pigmentosa. Dissertation, LMU München: Fakultät für Chemie und Pharmazie
... the absence of the GARP domain there is no longer a constraint on channel gating. Now, binding of cGMP to the CNGA1 subunits is sufficient for full activation. The exact molecular mechanism underlying the action ...
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Differential expression of hyperpolarization-activated cyclic nucleotide-gated channel subunits during hippocampal development in the mouse
... The hippocampus originates from the dorsomedial tel- encephalon, which commences its invagination to build the medial walls of the telencephalic hemispheres at ap- proximately E11 in the mouse. The differential gene pat- ...
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Phylogeny and effects of anoxia on hyperpolarization activated cyclic nucleotide gated channel gene expression in the heart of a primitive chordate, the Pacific hagfish (Eptatretus stoutii)
... The ancestral hagfishes are believed to have diverged from the vertebrate lineage over 500 million years ago and prior to the genome duplications postulated for the vertebrate lineage (Ota and Kuratani, 2007). Despite ...
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Molecular Mechanisms of a Retinal Cyclic Nucleotide-Gated Channel
... Cyclic nucleotide-gated (CNG) channels mediate the transduction of light signals to electrical signals in vertebrate ...CNG channel (CNGA1) as a model to illustrate the analytical solutions ...
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An investigation into the role of the hyperpolarisation-activated cyclic nucleotide-gated on channels in dorsal root ganglion neurons in rat models of chronic inflammatory and neuropathic pain
... hyperpolarisation[activated,! cyclic[nucleotide!gated!{HCN}!ion!channel!subunits! {HCN154}!changed!in! dorsal!root! ganglion!{DRG}!neurons!following!chronic! pain! ...HCN! channel! ...
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The role of an ancestral hyperpolarization activated cyclic nucleotide gated K+ channel in branchial acid base regulation in the green crab, Carcinus maenas
... C. maenas as generated by Verbruggen et al. (2015). A discrete gamma distribution was used to model evolutionary rate differences among sites between all sequences included in the gene tree analysis (six categories; +G, ...
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CURRENT UNDERSTANDING OF HYPERPOLARIZATION ACTIVATED AND CYCLIC NUCLEOTIDE GATED (HCN) CHANNELS: A REVIEW
... HCN channel function as part of the aetio-pathogenesis of neuropathic pain, certain epilepsies and ...HCN channel still remains to be elaborated, it will be interesting to see how many of potential drug ...
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The expression of hyperpolarization activated cyclic nucleotide gated (HCN) channels in the rat ovary are dependent on the type of cell and the reproductive age of the animal: a laboratory investigation
... There are age related changes in potassium, calcium and sodium channel expression [9-15]. In the data presented in this report, HCN1 and HCN2 had minimal variation through the aging process, with HCN1 only ...
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Hyperpolarization-activated cyclic nucleotide gated channels: a potential molecular link between epileptic seizures and Aβ generation in Alzheimer’s disease
... alterations in HCN1 channel activity. Indeed, APP metab- olism is thought to be largely regulated by APP-binding partners [14]. Therefore, we next explored the hypothesis that HCN1 might be involved in regulating ...
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Modulation of cyclic nucleotide gated channels and regulation of vertebrate phototransduction
... CNG channel. Parallel experiments performed on rod CNG channel α-subunits expressed in Xenopus laevis oocytes, which have their own IGF-I receptors, show that IGF-I also increases the cGMP sensitivity of ...
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Consequences of Dimerization of the Voltage-Gated Proton Channel
... The apparent discrepancy between the two suggested dimer interfaces could be explained in at least two ways. In one, the TM domains of the two protomers, although tethered by coiled-coil interactions within the ...
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Molecular and genetic basis of sudden cardiac death
... Two categories of monogenic heart disease predispose to SCD. These are genetic disorders of heart rhythm and familial cardio- myopathy. Cardiomyopathy is discussed in depth elsewhere in this Review series (13), and ...
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Overexpression of rod photoreceptor glutamic acid rich protein 2 (GARP2) increases gain and slows recovery in mouse retina
... CNG channel is a heterotetramer consisting of 3 α (CNGA1) and 1 β (CNGB1) subunits arranged around a central pore ...the channel β-subunit consists of 33 exons and has a bipartite structure com- prised of ...
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Voltage-gated proton channel in a dino agellate
... Proton channel genes were subsequently identi fi ed in human, mouse, and Ciona intestinalis, but their existence in dino- fl agellates remained uncon fi ...ton channel gene from a Karlodinium vene fi cum cDNA ...
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The first peptide gated ion channel
... cDNA for the FMRFamide precursor protein also encodes the peptides FLRFamide and pQFYRFamide (Lutz et al. 1992; Price et al. 1996b). Extensive comparison of the potencies of FLRFamide and FMRFamide on oocyte-expressed ...
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Unique reporter-based sensor platforms to monitor signalling in cells
... Cyclic AMP XPTM and Cyclic GMP XPTM Assay Kits Cell Signalling were used to determine the intracellular levels of cAMP and cGMP in HEK293 cells treated with forskolin, cyclic nucleotide [r] ...
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Rieder, Florian (2004): Wirkung der spezifischen Phosphodiesterase-Inhibitoren Roflumilast und Pumafentrine im Mausmodell der Dextran-Sodium-Sulfat-induzierten Kolitis. Dissertation, LMU München: Medizinische Fakultät
... Emesis induced by inhibitors of type IV cyclic nucleotide phosphodiesterase. (PDE IV) in the ferret[r] ...
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In vitro behavior of human intestinal mucosa The influence of acetyl choline on ion transport
... The possibility that the autonomic nervous system may influence the function of intestinal mucosa was investigated by assessing the effect of acetyl choline on ion transport in human intestine. Isolated pieces of ...
9
The role of cyclic nucleotides and cyclic nucleotide phosphodiesterase in development of Mysococcus santus analysis of mutants.
... aggregation or sporulatwn. Type II strains were able to aggregate but did not spbrulate, A strain classed as a Type III strain was a low capacity fruiter. r Each category displayed defects in cyclic ...
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Article The role of Voltage-Gated Sodium Channel (VGSC) gene mutations in the resistance of Aedes aegypti L. to pyrethroid permethrin in Palembang and Jakarta, Indonesia
... voltage-gated sodium channel is associated with knockdown resistance to permethrin in Aedes aegypti. Martins, A.J.; Lins, R.M.M; Linss, J.G.B.; Peixoto A.A.; Valle, D; Voltage gated sodi[r] ...
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