Cyclin-dependent kinase 2 (Cdk2)
Cyclin-dependent kinase 2 is an ideal target for ovary tumors with elevated cyclin E1 expression
... that Cyclin E1 (CCNE1) was overexpressed in 30% of established ovarian cancer cell ...of cyclin-dependent kinase 2 (Cdk2), we investigated the effect of Cdk2 inhibitor on ...
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Downregulation of cyclin dependent kinase 2 activity and cyclin A promoter activity in vascular smooth muscle cells by p27(KIP1), an inhibitor of neointima formation in the rat carotid artery
... of cyclin-dependent kinase 2 (cdk2) activity in serum-deprived VSMCs was associated with the formation of complexes between cdk2 and its inhibitory protein p27(KIP1) ...of ...
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Optimization of luminescent assay for screening of cyclin-dependent kinase 2 inhibitors
... compromised. Cyclin-dependent kinases ensure the tight regulation of the cell cycle execution by mediating phosphorylation of cellular ...the cyclin-dependent kinase 2 activity ...
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Synthesis of Some New Fluorine Substituted Thiobarbituricacid Derivatives as Anti HIV1 and Cyclin Dependent Kinase 2 (CDK2) for Celltumer Division Part II
... Cancer cells differ from the normal cells in a biochemical processes particularly during the control of cell growth and division. Leukemia is one of the major types of cancer affecting significant segment of the popula- ...
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Regulation of Ciz1 by Cyclin A Cyclin Dependent Kinase 2 (CDK2) mediated phosphorylation
... recruiting cyclin A to these sites of DNA replication (Copeland et ...increased cyclin A-CDK2 activity; causing phosphorylation of several proteins (Petersen et ...
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Silencing or inhibition of H3K79 methyltransferase DOT1L induces cell cycle arrest by epigenetically modulating c-Myc expression in colorectal cancer
... -deoxyuridine); CDK2: Cyclin- dependent kinase 2; ChIP: Chromatin immunoprecipitation; Cimp − : :Low CpG island methylator phenotype; Cimp+: High CpG island methylator phenotype; C-Myc: ...
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MicroRNAs in systemic rheumatic diseases
... Argonaute; CDK2, cyclin-dependent kinase 2; EGFL7, epidermal growth factor-like domain 7; IFN, interferon; IL, interleukin; IRAK1, IL-1 receptor- associated kinase 1; MCP-1, ...
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Emerging Roles for Ciz1 in Cell Cycle Regulation and as a Driver of Tumorigenesis
... maintenance 2-7, (Mcm2-7)) ...of cyclin E- cyclin-dependent kinase 2 (CDK2) and Dbf4-dependent kinase (DDK) [5–7] through activation of the Cdc45, Mcm2-7 and ...
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The role of SCF ubiquitin-ligase complex at the beginning of life
... CCNE1: Cyclin E1; Cdk2: Cyclin-dependent kinase 2; CTB: Cytotrophoblast; EC: Endometrial carcinogenesis; EE2: 17 α -ethinylestradiol; EFS: Empty follicle syndrome; EGA: Embryonic ...
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Identifying and Characterizing circRNA-Protein Interaction
... O3; CDK2: Cyclin-dependent kinase 2; circRNAs: exonic circular RNAs; ciRNAs: intronic circular RNAs; EIciRNAs: a circular RNA contains exon and intron; HITS-CLIP: High-throughput ...
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IN SILICO INHIBITION OF PROTO ONCOGENE TYROSINE PROTEIN KINASE SRC (C SRC) BY ARISTOLACTAM A II, 4 ALLYL RESORCINOL AND STIGMAST 4 EN 3, 6 DIONE FOR ANTICANCER ACTIVITY OF PIPER BETLE LINN (PIPERACEAE): TRADITIONAL CLAIM REVALIDATED
... protein kinase Src (c-Src) and Cyclin dependent kinase 2 (CDK2) was selected based on their report of anticancer activity and listing in target prediction report of the selected ...
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Omega 3 polyunsaturated fatty acids inhibit cell proliferation by regulating cell cycle in fad3b transgenic mouse embryonic stem cells
... G1/S-specific cyclin-D1; Ccne1: G1/S-specific cyclin-E1; Cdk2: Cyclin- dependent kinase 2; Cdk4: Cyclin-dependent kinase 4; Cdk6: ...
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Rhomboid domain-containing protein 1 promotes breast cancer progression by regulating the p-Akt and CDK2 levels
... CDK2: Cyclin-dependent kinase 2; CHX: Cycloheximide; DCIS: Ductal carcinoma in situ; ER: Estrogen receptor; ERAD: Endoplasmic reticulum- associated degradation; FACS: Fluorescence ...
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Effect of glutamine or glucose deprivation on the expression of cyclin and cyclin-dependent kinase genes in glioma cell line U87 and its subline with suppressed activity of signaling enzyme of endoplasmic reticulum–nuclei-1
... that cyclin-dependent ki- nase-2 associates with and is regulated by the regu- latory subunits of the complex, including cyclin A or E, but activity of cyclin-dependent ...
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G1/S phase cyclin dependent kinase overexpression perturbs early development and delays tissue specific differentiation in Xenopus
... embryo, cyclin A2/cdk2 RNA was injected into one cell at the 2-cell stage along with Bgal as a lineage ...where cyclin A2 and cdk2 were most strongly overexpressed, as judged by a ...
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Retroviral Cyclin Enhances Cyclin-Dependent Kinase-8 Activity
... of kinase assay blots with specific antibodies did not detect CDK8 in anti-CDK7 or anti-CDK9 IPs, and there was no detectable CDK9 in anti-CDK8 or CDK7 IPs, but small quan- tities of CDK7 were detectable by the ...
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Regulatory mechanisms of B cell responses and the implication in B cell-related diseases
... as cyclin-dependent kinase 4 (CDK4), CDK6, BCL2, MET, Notch, c-MYC, AXL and FOXP1 [48, 49, ...a 2′-O-methox- yethyl modification (2′-OM) are called antagomiRs ...
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A clinico-genomic analysis of soft tissue sarcoma patients reveals CDKN2A deletion as a biomarker for poor prognosis
... number of histologies, our statistical model accounted for tumor type, and CDKN2A was still a significant marker of poor prognosis. Furthermore, in our cohort, genetic sequencing was almost exclusively done on patients ...
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Overexpression of p21waf1 in Human T-Cell Lymphotropic Virus Type 1-Infected Cells and Its Association with Cyclin A/cdk2
... tyrosine kinase protein to Rb in the C pocket region ...the cyclin A/cdk2 complex specifically phosphorylates the threonine 821 site, both blocking and disrupting the binding of the LXCXE protein to ...
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Expression of an S phase stabilized version of the CDK inhibitor Dacapo can alter endoreplication
... Drosophila Cyclin E-Cdk2 complex (Lilly and Duronio, ...phase) Cyclin E-Cdk2 activity are required for repeated rounds of endocycle S phase (Follette et ...of Cyclin E-Cdk2 ...
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