cyclooxygenase-2 gene
Original Article Genetic association of cyclooxygenase-2 gene polymorphisms with Parkinson’s disease susceptibility in Chinese Han population
... nyl-1, 2, 3, 6-tetrahydropyridine (MPTP) -indu- ced PD in the substantia nigra ...COX2 gene effects the neurodegenerative process and plays an important role in the pathogenesis of PD ...kinase 2 ...
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Genetic polymorphisms in the cyclooxygenase 2 gene, use of nonsteroidal anti inflammatory drugs, and breast cancer risk
... of cyclooxygenase (COX)-2, which is over-expressed in many types of cancer, including breast cancer, and plays a major role in tumorigenesis ...PGE 2 , have an organ-site-specific effect of ...
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Original Article Association between 1195G>A polymorphism of cyclooxygenase-2 gene with lung cancer risk: a meta-analysis
... of cyclooxygenase-2 (COX-2) gene and the risk of lung cancer development have shown conflicting ...COX-2 gene increased the lung cancer risk in whole population (GG versus AA: ...
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Original Article Association between 8473T>C polymorphism in the cyclooxygenase-2 gene and the risk of nasopharyngeal carcinoma
... The gene for COX- 2, designated as PTGS2, carries several poly- morphisms, but few studies analyzed the rela- tion between COX-2 gene polymorphisms and nasopharyngeal ...COX-2 ...
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Association of Cyclooxygenase 2 Gene Polymorphism in Irritable Bowel Syndrome.
... The lower gastrointestinal tract is divided into five parts: the caecum, the ascending colon, the transverse colon, the descending colon, and the rectum. The large intestine (colorectum) begins at the caecum, which is ...
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The effect of risedronate on osteogenic lineage is mediated by cyclooxygenase 2 gene upregulation
... The mechanism by which bisphosphonates stimulate osteoblasts is not yet completely elucidated. Giuliani et al. [10] reported that the anabolic effect of BPs was associated with the stimulation of b-FGF, while Mundy et ...
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Induction of cyclooxygenase 2 in human umbilical vein endothelial cells by lysophosphatidylcholine
... induces cyclooxygenase-2 mRNA and protein ...of cyclooxygenase-2 is accompanied by the enhancement of both basal- and calcium ionophore A23187-induced synthesis of ...the ...
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Protein Never in Mitosis Gene A Interacting-1 regulates calpain activity and the degradation of cyclooxygenase-2 in endothelial cells
... Effect of PIN1 knockdown and calpain inhibition on COX-2 stability. KD and Control shRNA MAEC were treated with vehicle (DMSO) or 25 μM zVF for 1 h, then with LPS and IFN for 24 h. Cycloheximide (90 μg/ml) was ...
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Current biomarkers of canine mammary tumors
... these predispositions may vary depending on the geo- graphical location. However, no common mutations in dogs with CMT have been detected so far [2]. One of the main risk factors for tumor growth is sex hormones ...
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Common promoter variant in cyclooxygenase-2 represses gene expression: evidence of role in acute-phase inflammatory response
... We hypothesized that dysregulation of COX-2 expression has a role in COX-2–mediated pathology and that this, in part, may be due to functional changes in the 5 ⬘ transcrip- tional regulatory promoter region ...
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Impaired mucosal defense to acute colonic injury in mice lacking cyclooxygenase 1 or cyclooxygenase 2
... ing of acetic acid–induced gastric ulcers in mice (29). Selective COX-2 inhibitors have no effect on small intestinal crypt survival after irradiation in mice (9). The absence of involvement of COX-2 in ...
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Cyclooxygenase/lipoxygenase shunting lowers the anti cancer effect of cyclooxygenase 2 inhibition in colorectal cancer cells
... enzymes involved in the generation of prostaglandins and leukotrienes. In particular, COX-2 expression is upregu- lated in CRC and NSAIDs may reverse the carcinogenic process by inhibiting this enzyme. Recent ...
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Cyclooxygenase-2 (COX-2) inhibitors: future therapeutic strategies for epilepsy management
... release resulting in enhanced vascular permeability and cyto- skeletal changes in brain capillary endothelial cells [61]. The signaling pathways connecting such cytokines to COX-2 ex- pression may involve ...
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Clinicopathological and immunohistochemical features of lung invasive mucinous adenocarcinoma based on computed tomography findings
... Among the pathological findings, no statistically significant associations were observed between lymph node metastasis, lymphatic invasion, vascular invasion, or pleural involve- ment and the HRCT findings among the ...
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Assessment of cyclooxygenase-1 and 2 gene expression levels in chronic autoimmune thyroiditis, papillary thyroid carcinoma and nontoxic nodular goitre
... COX-2 gene was assessed using the ABI PRISM 7500 SDS Software (ABI PRISM 7500 Se- quence Detection System, Applied Biosystems), according to the manufacturer’s ...COX-2 gene were run with 5 μL ...
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Reduction in cancer risk by selective and nonselective cyclooxygenase-2 (COX-2) inhibitors
... the cyclooxygenase pathway produces various prostaglandins that have a diverse array of physiologic activities throughout the human system. These shortlived molecules appear not only to control the inflammatory ...
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Host cyclooxygenase 2 modulates carcinoma growth
... The data regarding the sublocalization of COX-2 in solid tumors are conflicting. COX-2 is expressed in some colon carcinoma cell lines (9–11), and its expres- sion can be induced in cultured rat intestinal ...
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Metal Enhanced Electrochemical Cyclooxygenase-2 (COX-2) Sensor for Biological Applications
... Cyclic voltammetry was used to characterize the elec- trode surface. Oxidizing the silver monolayer in the pres- ence of the goat anti-COX-2 antibody resulted in reactive silver oxides accompanied by electrons ...
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Sustained expression of MCP-1 by low wall shear stress loading concomitant with turbulent flow on endothelial cells of intracranial aneurysm
... on gene expression, a primary culture of ECs from human carotid artery was cultured and shear stress corresponding to the value ...the gene expression pro- file was obtained by RNA sequence–based CAGE ana- ...
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Netrin-1 attenuates the progression of renal dysfunction by blocking endothelial-to-mesenchymal transition in the 5/6 nephrectomy rat model
... Methods: Male Sprague – Dawley rats were divided into three groups (10 rats/group): sham-operated rats treated with control adenovirus; 5/6 Nx rats treated with control adenovirus; and 5/6 Nx rats treated with ...
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