Cyclooxygenase 2 inhibitors
A QSAR Study of 3, 4 Diaryloxazolones as Cyclooxygenase 2 Inhibitors
... A Quantitative Structure Activity Relationship (QSAR) study of 3, 4-Diaryloxazolones has been performed to evaluate the descriptors responsible for the COX-2 inhibitory activity of the molecules. The molecular ...
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In Vitro Interaction of Cyclooxygenase-2 Inhibitors with Radiation in Nasopharyngeal Carcinoma Cell line: Dependence on Sequence of Administration
... Whole cell lysates were prepared using the bcA protein assay kit (Pierce biotechnology, rockford, Il), separated by electrophoresis in polyacrylamide gel and transferred to nitrocellulose membrane. After blocking with ...
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PHARMACOPHORE SCREENING AND MOLECULAR DOCKING OF PHYTOCONSTITUENTS IN POLYGONUM SAGITTATUM FOR CYCLOOXYGENASE 2 INHIBITORS DISCOVERY
... Methods: The protein crystal structure of human COX-2 in complex with mefenamic acid (PDB code: 5IKR) was selected, its ligand-protein interaction was studied by employing LigandScout to obtain the pharmacophore ...
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Tolerance to alternative cyclooxygenase-2 inhibitors in nonsteroidal anti-inflammatory drug hypersensitive patients
... selective NSAID hypersensitivity, especially since some studies included patients with a long time interval, up to 72 hours, between intake of the culprit non selective NSAID and onset of symptoms [26,29,33]. Incorrect ...
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Non steroidal anti inflammatory drugs, Cyclooxygenase 2 inhibitors and paracetamol use in Queensland and in the whole of Australia
... (COX-2 inhibitors) were developed to inhibit mainly the 'inducible' cyclo- oxygenase associated with inflammation, cyclo-oxygen- ase-2 (COX-2) ...COX-2 inhibitors, were made ...
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Structure and quantitative structure-activity relationship (QSAR) for (±) 3, 5-diphenyl-2-thioxoimidazolidin-4-ones as prominent cyclooxygenase-2 inhibitors
... the cyclooxygenase inhibition activity of these ...the cyclooxygenase inhibition activity for these molecules that was obtained experimentally is compared with the calculated ...The cyclooxygenase ...
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Comparison of benefit–risk preferences of patients and physicians regarding cyclooxygenase-2 inhibitors using discrete choice experiments
... Cox-2 inhibitors as treatments for arthritis, leading to several meaningful ...Cox-2 inhibitors, such as PAI and FUN, than with the risk of GI and CV adverse events, whereas physicians ...
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Synthesis and invitro evaluation of novel benzoxazole derivatives as specific cyclooxygenase – 2 inhibitors
... Methyl 2-(2-chloroacetamido) benzoxazole-5-carboxylate (V, ...methyl 2-{(2-dialkylamino)acetamido)}-benzoxazole- 5-carboxylates (VII) by their spectral ...
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Effects of cyclooxygenase inhibitors on the alterations in lung mechanics caused by endotoxemia in the unanesthetized sheep
... metabolism as mediators of the endotoxin-induced alterations in lung mechanics was investigated by studying sheep before and after cyclooxygenase inhibition with sodium meclofenamate and ibuprofen. Sheep were ...
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Synthesis, Cyclooxygenase Inhibition, Anti inflammatory Evaluation and Gastric Liability of Some Novel Indole Derivatives as Selective COX 2 Inhibitors
... for Cyclooxygenase (COX-1/COX-2) inhibitory activity and in vivo for their anti-inflammatory activity in comparison with the parent drug ...SO 2 Me or SO 2 NH 2 group as a pharmacophore ...
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Host cyclooxygenase 2 modulates carcinoma growth
... of cyclooxygenase have been char- acterized, COX-1 and ...of cyclooxygenase, the result of other effects, or both. Oshima et al. (2) evaluated COX-2 –/– mice to ...
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Current biomarkers of canine mammary tumors
... In veterinary medicine, some studies have shown that the expression of one or both receptors was more fre- quent in benign tumors, and in general, its expression was related to a more favorable prognosis [87, 89, 91]. ...
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Impaired mucosal defense to acute colonic injury in mice lacking cyclooxygenase 1 or cyclooxygenase 2
... during the recovery period after DSS treatment (19). However, it is likely that COX-2 also acts through com- plementary mechanisms. Recently, COX-2 has been reported to mediate oral immunologic tolerance to ...
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Thromboxane and Stable Prostaglandin Endoperoxide Analogs Stimulate Water Permeability in the Toad Urinary Bladder
... acid, inhibitors of prostaglandin and thromboxane A 2 synthesis, thromboxane B 2 stimulated water flow in a dose-dependent ...cm 2 hemibladder surface area, while U46619 (1 µM) stimulated ...
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Cyclooxygenase 2 and selenium in breast cancer
... There was significant increase in serum alkaline phosphatase (AlP) and this is agreement with Keshaviah et al., who concluded that AlP alone was abnormal in a high proportion of breast cancer patients with bone ...
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Prostaglandin levels in seminal plasma and sperm extracts of the domestic turkey, and the effects of cyclooxygenase inhibitors on sperm mobility
... inhibitors of both COX-1 and COX-2 produced the same degree of inhibition, even at the concentration of 0.1 mM, a level at which the COX-2 inhibitor was reported to have no inhibitory effect on COX-1 ...
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Effect of a hormone-releasing intrauterine system (Mirena<sup>®</sup>) on aromatase and Cox-2 expression in patients with adenomyosis submitted or not, to endometrial resection
... Group C consisted of 43 patients submitted to endometrial resection between March 2009 and September 2011 in whom pathology revealed adenomyosis. Since they had not been submitted to any hormonal treatment for ...
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Reversal of High dietary fructose-induced PPARα suppression by oral administration of lipoxygenase/cyclooxygenase inhibitors
... Male Sprague-Dawley rats weighing approximately 180– 200 g first maintained on a rat chow diet and then were divided into 6 groups and were switched to a high-fruc- tose diet (TD89247; Harlan Teklad, Madison, WI) that ...
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Modulation of CXCR3 ligand secretion by prostaglandin E2 and cyclooxygenase inhibitors in human breast cancer
... inhibits IFN-g induced CXCL9 and CXCL10 secretion from breast cancer cells and that, conversely, the COX inhibitors acetylsalicylic acid (ASA) and indomethacin augment this release. Inverse correlation of COX ...
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Cyclooxygenase/lipoxygenase shunting lowers the anti cancer effect of cyclooxygenase 2 inhibition in colorectal cancer cells
... enzymes involved in the generation of prostaglandins and leukotrienes. In particular, COX-2 expression is upregu- lated in CRC and NSAIDs may reverse the carcinogenic process by inhibiting this enzyme. Recent ...
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